Gastric Cancer

The clinical significance of miR-7-5p downregulation in gastric dysplasia and gastric cancer tissue

Authors: Sara Omrani, Ali Zare, Shahriar Tarighi, Hamid Ghaedi, Mir Davood Omrani

miRNAs have been involved in the pathogenesis of several cancers such as gastric cancer (GC.). In the following study we analyzed the expression of miR-7 in gastric cancer samples compared non-tumor tissues and gastric dysplasia (GD) samples with patients’ clinico-pathological data and its potential as diagnostic biomarker. We first analyzed its exp.. Read More»

Genet. Mol. Res. 18(4):

Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological approaches for precision medicine

Authors: Fehmida Bibi, Peter Natesan Pushparaj, Muhammad I. Naseer, Muhammad yasir, Esam I. Azhar

MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate the differential expression of genes. The expression of miRNAs is dysregulated in various types of cancers, including Gastric Cancer (GC), and has both prognostic and diagnostic potential. To interpret the role of miRNA expression in GC, we evaluated the expre.. Read More»

Genet. Mol. Res. 16(4):

gmr16039845

DOI:

10.4238/gmr16039845

S100A4 expression and prognosis of gastric cancer: a meta-analysis

Authors: Y. Wang1*, L.-B. Zhou1* and X.-H. Li2

The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform li.. Read More»

Genet. Mol. Res. 13(4):

2014.December.12.1

DOI:

10.4238/2014.December.12.1

Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population

Authors: C.-P. Zhou, H.-Z. Pan, F.-X Li, N.-Y. Hu, M. Li and X.-X. Yang

Evidence suggests that some genetic variants are risk factors for both colorectal cancer (CRC) and gastric cancer (GC). Thus, we selected 12 reported single nucleotide polymorphisms (SNPs) from genome-wide association studies of CRC and conducted this case-control study to assess the associations between these SNPs and the ris.. Read More»

Genet. Mol. Res. 13(2):

http://dx.doi.org/2014.May.9.10

DOI:

http://dx.doi.org/10.4238/2014.May.9.10

Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer

Authors: M. Qi, D.M. Liu, L.L. Pan and Y.X. Lin

Numerous studies have evaluated the association between the human interleukin-10 gene -592C>A polymorphism and gastric cancer risk. However, the results have been inconsistent. This meta-analysis was designed to resolve these controversies. Systematic searches of the electronic databases Embase, PubMed, and Google Scholar were performed to identify rel.. Read More»

Genet. Mol. Res. 13(4):

Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer

Authors: J. Jin, L. Xie, C.H. Xie and Y.F. Zhou

We aimed to explore the association between aberrant DNA methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) genes with gastric cancer. A total of 283 gastric cancer patients who were confirmed by pathological diagnosis were included in our study. Aberrant DNA methylation of MGMT.. Read More»

Genet. Mol. Res. 13(2):

http://dx.doi.org/2014.May.30.9

DOI:

http://dx.doi.org/10.4238/2014.May.30.9

HMGB3 characterization in gastric cancer

Authors: Y. Gong, Y. Cao, L. Song, J. Zhou, C. Wang, B. Wu

Gastric cancer is a major health problem worldwide; it is the second most common cause of cancer death in the world. Recent studies indicate that the high-mobility group (HMG) of chromosomal proteins is associated with cancer progression. However, HMGB3 has been little studied. We analyzed the co-expression network between HMG.. Read More»

Genet. Mol. Res. 12(4):

2013.December.2.1

DOI:

10.4238/2013.December.2.1

Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians

Authors: Y. Zhang, Z.T. Wang and J. Zhong

The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95.. Read More»

Genet. Mol. Res. 11(3):

2012.August.13.6

DOI:

10.4238/2012.August.13.6

Screening for genes that are differentially-expressed between gastric cancer cells and gastric tumor sphere cells using the gene chip technique

Authors: W.H. Shi, Y.B. Yu, Z.-Y. Li, X.-C. Guo, Z.-L. Wei and Z.-H. Zheng

The purpose of this study was to screen for genes that were differentially expressed between a human gastric carcinoma cell line (HGC-27) and their tumor spheres, using the gene chip technique. The HGC-27 cells and tumor sphere cells were cultured in vitro in a sterile environment. Total RNA was extracted from both sa.. Read More»

Genet. Mol. Res. 14(4):

2015.November.18.54

DOI:

10.4238/2015.November.18.54

SET8 expression is associated with overall survival in gastric cancer

Authors: X.L. Shi, Z.J. Guo, X.L. Wang, X.L. Liu, G.F. Shi

Genet. Mol. Res. 14(4):

2015.December.1.12

DOI:

10.4238/2015.December.1.12