Gastric Cancer
Association between the CDH1-472delA and -160C>A polymorphisms and diffuse and intestinal gastric cancer in a Mexican population
Authors: A.R. Bustos-Carpinteyro, N. Delgado-Figueroa, E. Santiago-Luna, M.T. Maga�±a-Torres and J.Y. S�¡nchez-L�³pez
Gastric cancer (GC), the third leading cause of cancer-related deaths in Mexico and worldwide, can be classified into diffuse (DGC) or intestinal (IGC) types based on its histological characteristics. DGC is characterized by reduced expression of the cell adhesion protein E-cadherin, which is encoded by CDH1. The -472delA (rs5030625) and -160C>A (rs162.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038715
- DOI:
- 10.4238/gmr.15038715
Serum miR-200c expression level as a prognostic biomarker for gastric cancer
Authors: H.-P. Zhang,F.-B. Sun, S.-J. Li
The aim of the present study was to analyze the serum expression level of microRNA-200c (miR-200c) in gastric cancer (GC) patients and to determine the relationship between this expression and clinicopathological features and survival. Serum samples were obtained from 98 patients with GC between February 2008 and January 2013... Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.2
- DOI:
- 10.4238/2015.December.7.2
Screening and identification of peritoneal metastasis-related genes of gastric adenocarcinoma using a cDNA microarray
Authors: F.H. Bai, N.J. Wang, J. Wang, L. Yang, F.M. Zhang, F. Yin, J. Liang, K.C. Wu and D.M. Fan
With the aim of identifying peritoneal metastasis-related genes in gastric cancer, we performed a broad analysis of differential gene expression between the parental cell line GC9811 and its highly metastatic peritoneal counterpart, cell line GC9811-P. Two fluorescent cDNA probes, labeled with Cy3 and Cy5 dyes, were prepared f.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.25.1
- DOI:
- 10.4238/2012.June.25.1
Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer
Authors: F.Q. Li, B. Xu, Y.J. Wu Z.L. Yang and J.J. Qian
Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray analysis and bioinformatic analysis were used to compare miRNA expression.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.17
- DOI:
- 10.4238/2015.January.30.17
Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
Authors: Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.2
- DOI:
- 10.4238/2012.November.12.2
Association between the epithelial cadherin -160C/A gene polymorphism and diffuse gastric cancer risk: a meta-analysis.
Authors: X.W. Chen, J.X. Sun, Z.N. Wang, P. Gao, Y.X. Song, J.F. Cao, B. Liu and H.M. Xu
Several previous studies have investigated whether the -160C/A epithelial cadherin promoter polymorphism confers an increased risk of diffuse gastric cancer (DGC), but conflicting results have been reported. To explore further the association of this polymorphism with DGC susceptibility, we performed an extensive search of rel.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.13.3
- DOI:
- http://dx.doi.org/10.4238/2014.February.13.3
Absolute quantification of free tumor cells in the peripheral blood of gastric cancer patients
Authors: N. Bayat, M.M. Mokhtari, M. Rezaei-Tavirani, A. Baradaran-rafii, S. Rahman Zadeh, S. Heidari-Keshel and F. Ghasemvand
Gastric cancer remains the third most common cancer in the world. Metastatic disease is a major cause of death in about half of the patients; therefore, early diagnosis is crucial for successful outcome. This study applied a sensitive method for the detection of circulating tumor cells using specific tumor markers for early de.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.16.1
- DOI:
- http://dx.doi.org/10.4238/2014.June.16.1
Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population
Authors: W.M. Zhao, P. Shayimu, L. Liu, F. Fang and X.L. Huang
We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer. A hospital-based case-control design was performed, and 153 patients and 207 control subjects were consecutively selected from the Third Affiliated Hospital between May 20.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037864
- DOI:
- 10.4238/gmr.15037864
Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric cancer cells
Authors: Z.Y. Guo, G.D. Yao, L.P. Fu, Z.G. Fu and B. Hou
The aim of this study was to observe the effects of recombinant human endostatin on the proliferation and apoptosis of mouse gastric cancer cells, and explore some possible mechanisms of recombinant human endostatin inhibition of cancer. A murine gastric cancer xenograft model was established. A total of 20 mice were divided into two groups (control and e.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.17
- DOI:
- 10.4238/2015.May.18.17
Relationship between clinicopathological features and HIF-2�± in gastric adenocarcinoma
Authors: N. Li, H.X. Wang, C. Qin, X.H. Wang and F.Y. Han
Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor-2α (HIF-2α) plays an essential role in oxygen homeostasis. Expression of HIF-2α-inducible genes is associated with tumor progression. In this study, we investigated this correlation immunohistochemically and using quantitative rever.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.19
- DOI:
- 10.4238/2015.February.13.19