Paper Highlights

Research Article   November 5, 2018
Genet. Mol. Res.: 17(4): 1-10. DOI: http://dx.doi.org/10.4238/gmr16039935

Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer

Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R gene (rs1053496 and rs12516866) are corre.. Read More»

Research Article   November 5, 2018
Genet. Mol. Res.: 17(4): 1-13. DOI: http://dx.doi.org/10.4238/gmr16039932

AtBTH1, a BTB domain-containing protein, influences sugar-responsive germination and seedling growth in Arabidopsis

Sugars function as signal molecules that regulate gene expression, growth, and development in plants, animals, and yeasts. As a contribution to understanding the molecular mechanisms of sugar responses, we identified and characterized an Arabidopsis thaliana BTB domain-containing protein of the H subfamily 1 (designated AtBTH1). The relative expression level of AtBTH1 was enhanced by exogenous .. Read More»

Research Article   November 5, 2018
Genet. Mol. Res.: 17(4): 1-11. DOI: http://dx.doi.org/10.4238/gmr16039934

Estimative of genetic diversity in germ-plasm of elephant grass using the Gower algorithm

This work aimed at estimating the genetic divergence among 85 accessions of elephant-grass using the Gower algorithm for the joint study of quantitative and qualitative traits. The experiment was conducted in the city of Campos dos Goytacazes, Rio de Janeiro state, Brazil, with of 85 elephant-grass genotypes. It was applied a randomized block experimental design with two replications. The exper.. Read More»

Research Article   December 5, 2018
Genet. Mol. Res.: 17(4): 1-12. DOI: http://dx.doi.org/10.4238/gmr16039936

Determination of CEBPA mutations in pediatric acute leukemia

The CCAAT/enhancer-binding protein-alpha (CEBPA) is lineage-specific transcription factor in the hematopoietic system. Several studies have reported the presence and frequency of CEBPA mutations.In this study, we aimed the clinical features and the prognostic significance associated with CEBPA mutations in 30 pediatric patients with acute leukemia.In addition, association between found variants.. Read More»

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