Table of contents: 2018
Plant Genetics   Research Article

Genetic inheritance of traits relating to seedling and size in ornamental pepper

Authors: Angela Maria dos Santos Pessoa, Elizanilda Ramalho do Rêgo, Michelle Gonçalves de Carvalho, Cristine Agrine Pereira dos Santos, Júlio Carlos Polimeni de Mesquita, Mailson Monteiro do Rêgo

Pepper exhibits genetic diversity and versatility in use. Knowledge of the genetic control of traits in peppers is of great importance to breeding programs given the variety of types, sizes, colors and flavors. The aim of the present study was to examine the inheritance of seedling and plant traits in ornamental pepper (Capsicum annuum). The experiment was conducted in a greenhouse in the plant.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039938

DOI: http://dx.doi.org/10.4238/gmr16039938

Plant Genetics   Research Article

Genetic diversity, agronomic potential and reaction to downy mildew in genotypes of biofortified mini lettuce

Authors: A.C.P. Jacinto, A.J. Silveira, R. Castoldi, G.M. Maciel, A.C.S. Siquieroli and T.F.N. Mendonça, A.P. Souza, M.V. Marin, L.T. Braz

Lettuce is one of the most consumed leaf vegetables in the world, highlighting itself as a novelty in the market as mini type cultivars. During the winter the downy mildew can lead to severe damage. Thus, the objective of this work was to evaluate the genetic diversity, agronomic potential and downy mildew reaction in biofortified mini lettuce genotypes. The experiment was carried out in the Un.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039939

DOI: http://dx.doi.org/10.4238/gmr16039939

Human Genetics   Case Reports

Glioblastoma in a 20-year-old female patient after Chikungunya infection

Authors: L.O. Mourão, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves

We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX positive, Ki-67 positive in 35% of neoplast.. Read More»

Genet. Mol. Res. 18(1):

Human Genetics   Research Article

Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer

Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy

    Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer development and progression. Setting: National cancer instit.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039942

DOI: http://dx.doi.org/10.4238/gmr16039942

Medical Genetics   Research Article

Relationship between melanoma-associated antigen 1 (MAGE-A1) gene polymorphisms and colorectal cancer development

Authors: Mikhlid Almutairi and Abdelhabib Semlali

In the Saudi population, colorectal cancer (CRC) is the first and third most common malignancy among males and females, respectively. The CRC risk is associated with the expression of certain genes, which can be used for prognoses and for finding screening-related biomarkers. One such gene is melanoma-associated antigen 1 (MAGE-A1); however, little is known about this gene or its expression as .. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039940

DOI: http://dx.doi.org/10.4238/gmr16039940

Medical Genetics   Research Article

NNT and NNT-AS1 expression levels are not different between bipolar patients and healthy subjects

Authors: Soudeh Ghafouri-Fard, Mohammad Taheri, Vahid Kholghi Oskooie, Mir Davood Omrani, Arezou Sayad

Nicotinamide nucleotide transhydrogenase (NNT) participates in redox and energy interconnections. Nnt silencing in N27 dopaminergic cells has changed basal, extra, and greatest mitochondrial oxygen absorption rates and made these cell vulnerable to constant upsurges in H2O2. NNT-antisense RNA1 (NNT-AS1) is transcribed from the opposite stand of NNT gene and is possibly involved in regulation of.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039943

DOI: http://dx.doi.org/10.4238/gmr16039943

Medical Genetics   Research Article

The clinical significance of miR-7-5p downregulation in gastric dysplasia and gastric cancer tissue

Authors: Sara Omrani, Ali Zare, Shahriar Tarighi, Hamid Ghaedi, Mir Davood Omrani

miRNAs have been involved in the pathogenesis of several cancers such as gastric cancer (GC.). In the following study we analyzed the expression of miR-7 in gastric cancer samples compared non-tumor tissues and gastric dysplasia (GD) samples with patients’ clinico-pathological data and its potential as diagnostic biomarker. We first analyzed its expression by real-time qRT– PCR in h.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039944

DOI: http://dx.doi.org/10.4238/gmr16039944

Human Genetics   Research Article

Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer

Authors: Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard

Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues (ANCTs) to find their putative role in .. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039945

DOI: http://dx.doi.org/10.4238/gmr16039945

Human Genetics   Review Article

Integrative omics of ovarian cancer

Authors: Yanisa Rattanapan and Takol Chareonsirisuthigul

Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of cancer are the continual debate. Due to t.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039946

DOI: http://dx.doi.org/10.4238/gmr16039946

Microbial Genetics   Research Article

High concentrations of sacharose lead to metabolic changes that favor the formation of co-products in ethanolic fermentation by Zymomonas mobilis

Authors: Bruno Souza dos Santos, Túlio Diego da Silva, Danilo Cavalcanti Ramos, Carolina Barbosa Malafaia, Lívia Caroline Alexandre de Araújo, Mariana Gomes Vidal Sampaio, Lucas Weba Soares, Alexandre Gomes da Silva, Fabiane Rabelo da Costa Batista, Patricia Maria Guedes Paiva, Luís Cláudio Nascimento da Silva, Maria Tereza dos Santos Correia, Glicia Maria Torres Calazans and Marcia Vanusa da Silva

Z. mobilis has attracted great biotechnology interest in recent decades due to its unique metabolism and the ability to produce bioethanol from simple sugars in an effectively and quickly way. Z. mobilis also produce other bioactive products as fructose, gluconic acid, sorbitol, levan, fructo-oligosaccharides. This study aimed to identify proteins differentially expressed by Z. mobilis ZAG-12 u.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039929

DOI: http://dx.doi.org/10.4238/gmr16039929

Medical Genetics   Research Article

Determination of CEBPA mutations in pediatric acute leukemia

Authors: Dilara Fatma Akın Balı, Deniz Aşlar Öner, Emin Kürekçi, Nejat Akar

The CCAAT/enhancer-binding protein-alpha (CEBPA) is lineage-specific transcription factor in the hematopoietic system. Several studies have reported the presence and frequency of CEBPA mutations.In this study, we aimed the clinical features and the prognostic significance associated with CEBPA mutations in 30 pediatric patients with acute leukemia.In addition, association between found variants.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039936

DOI: http://dx.doi.org/10.4238/gmr16039936

Animal Genetics   Research Article

Estimative of genetic diversity in germ-plasm of elephant grass using the Gower algorithm

Authors: A.K.F. Vidal, R.F. Daher, R.S. Freitas, W.F. Stida, B.R. da S. Menezes, A.V. Pereira, V.B. da Silva, F.D. Tardin and L.J. da S. de Oliveira

This work aimed at estimating the genetic divergence among 85 accessions of elephant-grass using the Gower algorithm for the joint study of quantitative and qualitative traits. The experiment was conducted in the city of Campos dos Goytacazes, Rio de Janeiro state, Brazil, with of 85 elephant-grass genotypes. It was applied a randomized block experimental design with two replications. The exper.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039934

DOI: http://dx.doi.org/10.4238/gmr16039934

Plant Genetics   Research Article

Genetic variability in morphological characters among Fig tree accessions Fig genetic conservation

Authors: Maria Gabriela Fontanetti Rodrigues*, Laís Naiara Honorato Monteiro, Antonio Flávio Arruda Ferreira, Tatiane Paes Dos Santos, Bruno Ettore Pavan, Vitos Antônio Benites Neves, Aparecida Conceição Boliani

Fig is among the twenty main fruits exported by Brazil, which is the eighth largest producer of fig in natura in the world. The characterization of active germplasm banks (AGBs) of fig has thus become an important line of research, as it is necessary to gather information from this to carry out adequate management projects. The objective of this study was to characterize the morphologies of 42 .. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039931

DOI: http://dx.doi.org/10.4238/gmr16039931

Human Genetics   Research Article

MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection

Authors: Patricia Milhoransa, Carolina Caruccio Montanari, Mariane Dos Santos, Marina Sieber, Roberto Ceratti Manfro

Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has many limitations including risk and cost. T.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039933

DOI: http://dx.doi.org/10.4238/gmr16039933

Plant Genetics   Research Article

AtBTH1, a BTB domain-containing protein, influences sugar-responsive germination and seedling growth in Arabidopsis

Authors: J.E. Hwang, Y.J. Kim, M.H. Shin, J. Park, W. Choi, D.J. Yun and H.C. Park

Sugars function as signal molecules that regulate gene expression, growth, and development in plants, animals, and yeasts. As a contribution to understanding the molecular mechanisms of sugar responses, we identified and characterized an Arabidopsis thaliana BTB domain-containing protein of the H subfamily 1 (designated AtBTH1). The relative expression level of AtBTH1 was enhanced by exogenous .. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039932

DOI: http://dx.doi.org/10.4238/gmr16039932

Human Genetics   Research Article

Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer

Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali

Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R gene (rs1053496 and rs12516866) are corre.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039935

DOI: http://dx.doi.org/10.4238/gmr16039935

Medical Genetics   Research Article

Investigation of the role of apoptosis, necroptosis and DNA damage signaling pathways in multiple sclerosis

Authors: Romina Dastmalchi, Arezou Sayad, Mir Davood Omrani, Soudeh Ghafouri-Fard, Shahram Arsang-Jang, Mehrdokht Mazdeh, Mohammad Taheri*

Multiple sclerosis (MS) as the most common autoimmune disorder in the central nervous system is a major health problem. MS is a complex disease with multiple environmental and genetic factors participating in it. In the present study, we evaluated the expression of 3 genes named BCL2, CASP2 and CASP8 in peripheral blood of 50 MS patients and 50 healthy controls to investigate the role of apopto.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039937

DOI: http://dx.doi.org/10.4238/gmr16039937

Medical Genetics   Review Article

Long non-coding RNA-protein interaction: the preliminary step to track their biological functions

Authors: Amr. R. Ghanam, Wafa Ali, Mohnad Abdalla

RNA is not only an intermediate for the flow of genetic information between DNA and protein. The transcription of the entire genomes generates a myriad non-protein coding RNA in addition to protein coding genes. Among these transcripts, lncRNA which is the least well understood and they cannot be considered as merely transcriptional noises. Here, we review the emerging role of lncRNA interactio.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039920

DOI: http://dx.doi.org/10.4238/gmr16039920

Animal Genetics   Research Article

Comparing KISS1 and GPR54 genes between the two breeds of goats with low and high prolificacy

Authors: Jie Zheng, Sayed Haidar Abbas Raza, Xiang-Dong Zi, Jian-Yuan Lu

There is increasing evidence that kisspeptin, the peptide product of KISS1 gene and its receptor (GPR54), regulate reproductive processes through actions on other organs than hypothalamus. Therefore, the study for the first time, was conducted to investigate the nucleotide sequences and mRNA expression levels of KISS1 and GPR54 genes in pituitary, endometrium, ovary and oviduct of prolific Jint.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039922

DOI: http://dx.doi.org/10.4238/gmr16039922

Medical Genetics   Research Article

Association of ACE I/D, AT1R A1166C, CYP11B2 C344T polymorphism with essential hypertension in Asia: A meta-analysis

Authors: Jiang Yuepeng, Zhao Xiaoxuan, Zhao Yang, Sui Yanbo and Liu Li

Aim: To evaluate the association between ACE I/D, AT1R A11166C, CYP11B2 C344T gene polymorphisms and the risk of EH in Asia. Materials and Methods: Related case-control studies were collected, selected and screened; a meta-analysis was conducted to assess the association between polymorphism of target genes and essential hypertension. Results: 41 articles were included. Among them, 17 studie.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039923

DOI: http://dx.doi.org/10.4238/gmr16039923

Plant Genetics   Research Article

Genetic diversity and population structure of ancient Platycladus orientalis (Cupressaceae) in the Mausoleum of the Yellow Emperor revealed by SSR

Authors: Yao Xu1, Jiantao Zhao, Sheng Zhang, Zhong Zhao

Ancient trees can serve as genetic reservoirs for special genes, and they are of significance in genetic applications dealing with forest fragmentation, climate change and drought. The Mausoleum of the Yellow Emperor in Shaanxi China has the largest number of ancient Platycladus orientalis trees. Here, Simple sequence repeat (SSR) technique was used to study the genetic diversity of ancient P. .. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039924

DOI: http://dx.doi.org/10.4238/gmr16039924

Plant Genetics   Research Article

DNA Extraction from silica gel preserved common bean (Phaseolus vulgaris L.) leaves

Authors: Male. A.S, Kato. F, Mukankusi. C.M

Extraction of high-quality DNA from field specimen requires collection under liquid nitrogen which is not readily available in resource constrained laboratories in low- and middle-income countries (LMICs). A method of extracting DNA from silica gel preserved common bean (Phaseolus vulgaris L.) leaves is presented. Our method which does not involve the use of phenol, chloroform or isoamyl alcoho.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039926

DOI: http://dx.doi.org/10.4238/gmr16039926

Plant Genetics   Research Article

Genetic damage in Mexican and South American sweet corn varieties due to the use of herbicides (Nicosulfuron and Topramezone)

Authors: M.S. Reynoso, C.M. Alvarez, L.L. De la Cruz, J.F.G. Landeros, J.J.G. Sánchez, A.R.A. Villalobos

In order to encourage corn production, several herbicides such as nicosulfuron and topramezone are used. Though they offer great advantages, they may affect crop productivity and may even induce DNA damage. This study evaluated genotoxic activity at two nicosulfuron concentrations (40,000 and 80, 000 ppm) and at four topramezone concentrations (1480, 148, 14.8 and 1.48 ppm) in sweet corn and hy.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039921

DOI: http://dx.doi.org/10.4238/gmr16039921

Plant Genetics   Research Article

Analysis of the molecular diversity of R. solani isolates from five Ugandan agro-ecological zones using inter - simple sequence repeat markers

Authors: A.S. Male , F. Kato, P. Paparu and C.M. Mukankusi

This study used seven inter-simple sequence repeat (ISSR) markers to characterize 55 R. solani isolates in order to establish their genetic diversity. The isolates were from five common bean growing agro-ecological zones of Uganda; the Southwest highlands (SW), Lake Victoria crescent and Mbale farmlands (LVC), Teso farming system (TFS), the Northern mixed farmlands (N) and the Western highlands.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039927

DOI: http://dx.doi.org/10.4238/gmr16039927

Animal Genetics   Research Article

Genetic variants in exon 1 region of FABP3 gene in relation to milk production traits in Sahiwal and Karan Fries cattle

Authors: Alok Kumar Yadav and Anupama Mukherjee

The present study pertained to records on milk production and milk constituents of 100 Sahiwal cattle and 115 Karan Fries cattle, the data collected over a period of 2004 to 2016 from Animal Genetics and Breeding division from ICAR-National Dairy Research Institute, Karnal, Haryana. In Sahiwal SNP at position G649C was found to be highly associated with FLTMY and FL305DFY and however the associ.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039928

DOI: http://dx.doi.org/10.4238/gmr16039928

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