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Table of contents: 2021
Bioinformatics   Research Article

Screening of Chickpea Germplasm for Growth and Yield Related Traits under Agro-Climatic Conditions of Thal

Authors: N. Parveen, A. Masood, M. T. Mahmood, N. Khalid and M. Shahbaz

A field experiment comprising of fifty chickpea germplasm entries along with two commercial varieties (Punjab-2008 and Bittle-2016) was carried out for characterization of chickpea germplasm and screening of superior chickpea genotypes under agro-climatic conditions of Kallurkot (Thal, Punjab, Pakistan) at research area of Gram Breeding Research Station, Kallurkot (71.153°E and 32.923°N.. Read More»

Genet. Mol. Res. 19(5):

Human Genetics   Research Article

Endothelial Nitric Oxide Synthase (eNOS) Gene Polymorphisms and Risk of Aneurysmal Subarachnoid Hemorrhage: An Updated Meta-Analysis

Authors: N. Manabesh, M. Shubham, K. Amit, S. Rakhee, K. Pradeep

Previously published studies have examined whether the polymorphisms (G894T, 4b/a, and T786C) in the Endothelial Nitric Oxide Synthase (eNOS) gene are associated with risk of Aneurysmal Subarachnoid Hemorrhage (aSAH), have reported conflicting results. Thus, we performed a meta-analysis to examine the potential association between these three single nucleotide gene polymorphisms (SNPs) of eNOS .. Read More»

Genet. Mol. Res. 19(5):

Medical Genetics   Research Article

Diagnosis of Idiopathic Primary Infertility in a Consanguineous Infertile Family using Clinical and Molecular Cytogenetic Techniques

Authors: H. Muhammad, R. Khan, F. Wahab, I. Khan, B. Shah, A. Ali, N. Farooqi, Dil, N. Ali, F. Jalil and S. Ali

Background: Male infertility is a multifactorial medical problem affecting around 7% of the male population in whom 1% are affected by Non Obstructive Azoospermia (NOA). Despite of advanced diagnostic techniques, majority of the infertility cases remain idiopathic .Therefore more evidence based scientific research is required to investigate the underlying cause of this medical problem. The obje.. Read More»

Genet. Mol. Res. 19(5):

Plant Genetics   Research Article

Digital image analysis to quantify genetic divergence in passion fruit seeds

Authors: Leandro Rafael Fachi, Willian Krause, Henrique Duarte Vieira, Dejânia Vieira de Araújo, Petterson Baptista da Luz, Alexandre Pio Viana

Phenotyping through digital images has been used to evaluate morphological characteristics of seeds, providing fast, accurate results. The objective of this work was to estimate the genetic divergence among full-sibling families of passion fruit through morphophysiological characteristics of seeds using the Ward-MLM method. Seeds of 98 full-sibling families (FSF) of passion fruit from the breed.. Read More»

Genet. Mol. Res. 19(5):

Human Genetics   Research Article

Synonymous Variant of ACE Gene (rs4343) is Coupled with Early Age at Onset and Diminished Diabetic Duration in South Indian Diabetic Nephropathy Patients

Authors: S. Babi Heera, Umme Najiya Mahwish, Fazul Rahman, Sayeeduddin S, Sree Bhushan Raju , Parveen Jahan

Diabetic nephropathy (T2DN) is a major micro vascular complication associated with type-2 diabetes (T2DM). Abnormally active Renin Angiotensin System pathway is shown to influence the development of T2DN and the inter-individual variation with respect to ACE levels, a key enzyme in this pathway partly dependent on the genetic variants of ACE; suggests patient’s genotype .. Read More»

Genet. Mol. Res. 19(5):

Animal Genetics   Research Article

Protective effect of Vitamin D on Cardiac Mitochondrial Apoptotic pathway in Rats fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zienab Alrefaie, Hossam Awad

Background: Both diet quality and vitamin D status are important factors associated with many cardiovascular risk factors. Cardiac mitochondrial pathway of apoptosis has been associated with those factors. The current work aimed to assess the effect of chronic consumption of high fat diet (HFD) on the cardiac markers of mitochondrial pathway of apoptosis and whether vitamin D s.. Read More»

Genet. Mol. Res. 19(5):

Plant Genetics   Research Article

Dynamism of the breeding program for irrigated rice in Southeast Brazil

Authors: A.C. Silva Júnior, V.Q. Carneiro, I.G. Santos, W.G Costa, R.D.S. Rosado, C.D. Cruz and P.C. Soares

The estimation of the genotypic replacement rate is aimed at evaluating the performance of breeding programs. Thus, the objective of this study was to evaluate the dynamics of the genetic improvement program of flooded rice, developed in Minas Gerais, during the period from 1993 to 2016. We evaluated 210 lines in three environments between 1993 and 2016, in blocks, ranging from three to four re.. Read More»

Genet. Mol. Res. 19(5):

Medical Genetics   Research Article

Molecular Characterization of Tuf Gene and Antibiotic Susceptibility Patterns of Streptococcus Species in Local Population of Lahore, Pakistan

Authors: A. Mahmood, A. J. Sami and Q. Ali

Background: Multi Drug Resistance (MDR) is a global problem which is expeditiously increasing. Different antimicrobial drugs have been reported resistant against various Streptococcus species. This has been a threat to local individuals in all over the world specifically in developing countries including Pakistan. Decreased efficiency of drugs due to emergence of new resistance mechanisms in tr.. Read More»

Genet. Mol. Res. 19(4):

Medical Genetics   Research Article

Development and Transferability of Microsatellites Markers for Species of the Saltans Group of Drosophila (Diptera: Drosophilidae)

Authors: B.E. Roman, B.M. Trava and L. Madi-Ravazzi

The microsatellite markers (SSRs) are highly polymorphic, fast evolving, and regarded as neutral markers. Due to these traits, they have been widely used in population studies. The development of specific SSRs for a given species opens possibilities for the application, by means of transferability, in population studies of other species that are phylogenetically related, thereby optimizing time.. Read More»

Genet. Mol. Res. 19(4):

Human Genetics   Research Article

Fourier-Transform Infrared Spectroscopy, Antioxidant, Phytochemical and Antibacterial Screening of N-Hexane Extracts of Punica granatum, A Medicinal Plant

Authors: M. Sharif, F. Ansari, A. Malik, Q. Ali, Z. Hasan and N.U.H. Khan

Pomegranate is a fruit bearing plant belonging to Lythraceae; in botanic language it is called Punica granatum. It is been considered as a traditional medicine for the cure of many diseases. The purpose of this study was to investigate the antimicrobial activity and phytochemicals present qualitatively present in different parts of Pomegranate plant and to investigate antioxidant activity. Cold.. Read More»

Genet. Mol. Res. 19(4):

Human Genetics   Research Article

Environment Association in Chickpea Genotypes Utilizing AMMI And GGE Biplot Model

Authors: M.G. Azam, M.S. Iqba, M.A. Hossain and M.F. Hossain

Chickpea (Cicer arietinum L.) is generally grown-up underneath rainfed conditions inside the Barind space in Bangladesh, any place drought spell is that the principle production constraint. Genotype × Environment Interaction (GEI) was acclimated with making estimation of the grain yield and to get a handle on the G × E connection designs by analyzing the differential positioning of .. Read More»

Genet. Mol. Res. 19(4):

Human Genetics   Editorials

Genetics and Molecular Research: Editor Note

Authors: M. Akram

We are pleased to bring you the third issue of 2020. Along with few original papers and review papers, for this issue we decided to acknowledge the contributions during this COVID-19 crisis. We would like to appreciate your interest and supports towards the Genetics and Molecular Research. We understand the tough times that everyone is facing during this pandemic, but we assure you that we do o.. Read More»

Genet. Mol. Res. 19(4):

Medical Genetics   Research Article

Analysis of Micro-RNAs and Gene Expression Profiles in Gestational Diabetes Mellitus: A Consensus Approach

Authors: R. Bhushan, A. Rani, D. Gupta, I. Khan, A. Tripati, R. P. Singh and K. D. Pawan

Gestational Diabetes Mellitus (GDM) is a metabolic disorder characterized by insulin resistance. Lack of complete mechanisms involved in its pathophysiology makes its early diagnosis and treatment a difficult task. Recently, micro-RNAs are associated with many diseases including GDM. Its high stability in biological fluids and the ability to modulate genes at large scale makes it potent bio-mar.. Read More»

Genet. Mol. Res. 20(1):

Human Genetics   Editorials

Editor Note on Cardiovascular Genetics

Authors: M. Akram

Numerous cardiovascular issues can be acquired, including arrhythmias, innate coronary illness, cardiomyopathy, and high blood cholesterol. Coronary corridor sickness prompting respiratory failure, stroke, and cardiovascular breakdown can run in families, demonstrating acquired hereditary danger factors. Hereditary qualities can impact the danger for coronary illness from multiple points of vie.. Read More»

Genet. Mol. Res. 20(1):

Human Genetics   Editorials

An Editorial Note on Gene Therapy

Authors: M. Akram

Quality treatment is when DNA is acquainted into a patient with treat a hereditary infection. The new DNA normally contains a working quality to address the impacts of an illness causing change. There are two distinct sorts of quality treatment relying upon which kinds of cells are dealt with: • Physical quality treatment: move of a segment of DNA to any cell of the body that doesn't create .. Read More»

Genet. Mol. Res. 20(1):

Human Genetics   Editorials

A Short Note on Genetic Medicine on Colon Cancer

Authors: M. Akram

Around 5 to 10 percent of all colorectal malignant growths are brought about by a heritable transformation – a hereditary change that can be given from parent to kid. The two significant subtypes of innate colon disease are called familial adenomatous polyposis (FAP) and Lynch condition, otherwise called genetic nonpolyposis colorectal malignant growth (HNPCC). Moreover, some uncommon con.. Read More»

Genet. Mol. Res. 20(1):

Medical Genetics   Editorials

An Editorial on Antibiotic resistance from Arbitrary DNA Sequences

Authors: M. Akram

Anti-infection obstruction is a significant worldwide issue and the spread of safe microorganisms causes sickness and passing and comprises a significant expense to society. The most widely recognized path for microscopic organisms to create opposition is by taking up different sorts of obstruction qualities from different microorganisms. These qualities encode proteins (peptides) that can prom.. Read More»

Genet. Mol. Res. 20(1):

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