A brief study about DNA polymerase

Authors: Mohammad irani hafeez

Ribonucleases (RNases) are key players of the host immunity and contribute to maintaining tissue homeostasis and body fluid sterility. Secreted upon a diversity of cellular injuries, they mediate signaling processes, and have been classified as alarmins. Recent literature reveals how the immune response system uses common strategies to fight both cancer and infection. RNases participate in i.. Read More»

Genet. Mol. Res. 20(6):

Mitochondrial sirtuins in cancer

Authors: Mitochondrial sirtuins in cancer

All living beings require energy and the ultimate source for this energy in eukaryotes are mitochondria – originally an organelle of bacterial origin and eventually incorporated into the cytoplasm. Mitochondrial bioenergetics and dynamics are essential for the maintenance of cellular and metabolic homeostasis and any imbalance can result in diseases such as cancer. The mitochondrial matri.. Read More»

Genet. Mol. Res. 20(6):

Optogenetic approach improves neuroregenerative potential of stem cell-based therapies

Authors: Zahra-Soheila Soheili, Hoda Shams Najafabadi

Neural cells represent very limited regenerative capacity and cannot prevent the progression of central nervous system, and retinal, neurodegenerative diseases such as Alzheimer's, Parkinson's, Retinitis pigmentosa or age related macular degeneration diseases. Stem cell based regenerative strategies revealed successful preclinical transplantation outcomes, showing that exogenous stem cell d.. Read More»

Genet. Mol. Res. 20(6):

Co-targeting the EGFR and PI3K/Akt pathway to overcome therapeutic resistance in head and neck squamous cell carcinoma: What about autophagy?

Authors: Hannah Zaryouh, Jinthe Van Loenhout, Marc Peeters, Jan Baptist,Vermorken, Filip Lardon, An Wouters

Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR-targeting agents to treat head and neck squamous cell carcinoma. The Epidermal Growth Factor Receptor (EGFR) is overexpressed in the majority of Head and Neck Squamous Cell Carcinomas (HNSCC). This triggered the development of multiple anti-EGFR agents as a potential tre.. Read More»

Genet. Mol. Res. 20(6):

Genetic diversity and structure in Tunisian wild cherries and cultivated sweet cherries revealed by SSR markers

Authors: Azizi-Gannouni Thouraya, Ammari Youssef, Mnasri Rahmani Sameh, Ben Naceur M’barek, Albouchi Ali

Wild cherries are concentrated at high altitudes in northern Tunisia and cultivated sweet cherries are well adapted to low altitudes. This study aims to compare local wild and cultivated sweet cherries (Prunus avium L.) in the northern of Tunisia. To elucidate genetic variation of 21 cultivated sweet cherries (one landrace and 20 foreigner cultivars) and 4 local wild sweet cherries, we used.. Read More»

Genet. Mol. Res. 20(6):

Genital infections in females

Authors: Kazuki Sakai

Most ladies experience minor vaginal issues now and again. These issues can be identified with monthly cycles, sex, contamination, conception prevention techniques, maturing, medications, or changes after pregnancy. An adjustment in your typical vaginal release might be the principal indication of a vaginal issue. Changes in pee, for example, peeing all the more often or having a consuming incl.. Read More»

Genet. Mol. Res. 20(2):

Genetic Variability, Heritability and Genetic Advance in Bread Wheat

Authors: J. Prasad, A. Dasora, D. Chauhan, D.A. Rizzardi, S. K. Bangarwa, K. Nesara

The Present investigation was carried out using 50 bread wheat genotypes at Instructional Farm, Rajasthan College of Agriculture, Udaipur during Rabi, 2019-2020 in randomized block design with three replications. Analysis of variance revealed significant difference between genotypes for all the characters studied. Sufficient variability was present in the genotypes under study for all the chara.. Read More»

Genet. Mol. Res. 20(2):

Analysis of micro-RNAs and gene expression profiles in gestational diabetes mellitus

Authors: R. Bhushan, P. K. Dubey

Gestational diabetes mellitus (GDM) is a metabolic disorder characterized by insulin resistance. Lack of complete mechanisms involved in its pathophysiology makes its early diagnosis and treatment a difficult task. Recently, micro-RNAs are associated with many diseases including GDM. Its high stability in biological fluids and the ability to modulate genes at large scale makes it potent bio-mar.. Read More»

Genet. Mol. Res. 20(2):

Expression analysis of tocopherol key genes during seed development

Authors: A. Jai-uean, P. Sangin

Cleome viscosa (Cv) Linn is an annual oilseed crop plant that has high vitamin E, with the most active form represented as the tocopherols (α, β, γ and δ). These act as antioxidants in plants and are also essential components for human health. The gene expression profiles and partial-length cDNA encoding tocopherol cyclase (CvVTE1), homogentisic acid prenyltransferase (Cv.. Read More»

Genet. Mol. Res. 20(2):

Investigation the possibility of simple sequence repeats for generating a phase variation

Authors: Mohammad Abdul Rahmman Al-Maeni, Shaymaa Fouad Rasheed AlKhazraji

Phase variation mediating simple sequence repeat (SSR) in sipped strand mispairing is considered the most important mechanisms of genetic variation in N. meningitidis and in defense against host attack strategies despite elicitation of the immune system against commensal and pathogenic bacteria. We aimed to achieve in a silico study for determining the possibility of SSR within different positi.. Read More»

Genet. Mol. Res. 20(2):

Inheritance: A basic phenomenon in genetics

Authors: Suman Dhawan

Genet. Mol. Res. 20(3):

Genetic code: A major tool for DNA sequencing

Authors: Vinay Gupta

Hereditary code, the arrangement of nucleotides in Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) that decides the amino corrosive grouping of proteins despite the fact that the straight arrangement of nucleotides in DNA contains the data for protein groupings, proteins are not made straightforwardly from DNA... Read More»

Genet. Mol. Res. 20(3):

Mutation: A genetic change

Authors: James Watson

Mutation, an alteration in the genetic material (the genome) of a cell of a living organism or of a virus that is more or less permanent and that can be transmitted to the cell?s or the virus?s descendants... Read More»

Genet. Mol. Res. 20(3):

A brief study on Operon model

Authors: Steve Johnson

Operon, hereditary administrative framework found in microbes and their infections in which qualities coding for practically related proteins are bunched along the DNA... Read More»

Genet. Mol. Res. 20(3):

A spectrometrical study on Proteomics

Authors: Francis Jacob

Genet. Mol. Res. 20(3):

DNA and Chromatin Fibres

Authors: Mark Jones*

Chromatin is a complex of macromolecules made out of DNA, RNA, and protein, which is found inside the center of eukaryotic cells. Chromatin exists in two constructions: heterochromatin (united) and euchromatin (extended)... Read More»

Genet. Mol. Res. 20(4):

Lac operon: It's structure and function

Authors: Stephan Morris*

Early bits of knowledge into components of transcriptional guideline came from investigations of E. coli by scientists Francois Jacob and Jacques Monod. In E. coli, and numerous different microscopic organisms, qualities encoding a few distinct proteins might be situated on a solitary record unit called an operon. The qualities in an operon share the equivalent transcriptional guideline, yet ar.. Read More»

Genet. Mol. Res. 20(4):

DNA replication: Process in Eukaryotes

Authors: Harsh Pandey*

DNA replication, otherwise called semi-moderate replication, is the interaction by which DNA is basically multiplied. It is a significant interaction that happens inside the separating cell... Read More»

Genet. Mol. Res. 20(4):

A brief study on molecular sensors

Authors: Jack Hamilton*

A sub-atomic sensor, otherwise called a chemosensor or test, is a sub-atomic or supramolecular-based framework that can change test analyte connections into a sign which permits analyte detecting... Read More»

Genet. Mol. Res. 20(4):

A brief note on chromosomal abberation

Authors: Gerome Taylor*

Reverse transcriptase, additionally called RNA-coordinated DNA polymerase, a chemical encoded from the hereditary material of retroviruses that catalyzes the record of retrovirus RNA (ribonucleic corrosive) into DNA (deoxyribonucleic corrosive).. Read More»

Genet. Mol. Res. 20(4):

Fungal cell wall components are unique antifungal target

Authors: Chibuike Ibe

Fungal cell wall is absent in mammalian cell. In fungal the cell wall is fused to the cell physiology playing a crucial role in the entire cell functionality.. The cell wall components are synthesised and modified in the cell wall space by the actions of cell wall proteins through a range of signalling pathways that are all unique to fungi, thus making the cell wall and its components suitable .. Read More»

Genet. Mol. Res. 20(5):

Probiotic potential of novel Brazilian Lactobacillus crispatus strains

Authors: Vasco Azevedo

Lactobacilli are predominant bacterial species colonizing the vaginal surfaces of healthy women, where they play a protective role against opportunistic and polymicrobial infections such as Bacterial Vaginosis (BV). Several Lactobacillus species, especially L. crispatus, have been prospected for probiotic applications due to their potential antimicrobial and anti-inflammatory capacity. In the l.. Read More»

Genet. Mol. Res. 20(5):

A brief study about reverse transcriptase

Authors: Steven Anderson

Reverse transcriptase, additionally called RNA-coordinated DNA polymerase, a chemical encoded from the hereditary material of retroviruses that catalyzes the record of retrovirus RNA (ribonucleic corrosive) into DNA (deoxyribonucleic corrosive).. Read More»

Genet. Mol. Res. 20(5):

A brief study about DNA Polymerase

Authors: Stella Andrews

DNA polymerase I is a compound that partakes during the time spent prokaryotic DNA replication. Found by Arthur Kornberg in 1956, it was the main known DNA polymerase... Read More»

Genet. Mol. Res. 20(5):