Genetic inheritance of traits relating to seedling and size in ornamental pepper

Authors: Angela Maria dos Santos Pessoa, Elizanilda Ramalho do Rêgo, Michelle Gonçalves de Carvalho, Cristine Agrine Pereira dos Santos, Júlio Carlos Polimeni de Mesquita, Mailson Monteiro do Rêgo

Pepper exhibits genetic diversity and versatility in use. Knowledge of the genetic control of traits in peppers is of great importance to breeding programs given the variety of types, sizes, colors and flavors. The aim of the present study was to examine the inheritance of seedling and plant traits in ornamental pepper (Capsicum annuum). The experiment was conducted in a greenhouse in the plant.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039938

DOI: http://dx.doi.org/10.4238/gmr16039938

Genetic diversity, agronomic potential and reaction to downy mildew in genotypes of biofortified mini lettuce

Authors: A.C.P. Jacinto, A.J. Silveira, R. Castoldi, G.M. Maciel, A.C.S. Siquieroli and T.F.N. Mendonça, A.P. Souza, M.V. Marin, L.T. Braz

Lettuce is one of the most consumed leaf vegetables in the world, highlighting itself as a novelty in the market as mini type cultivars. During the winter the downy mildew can lead to severe damage. Thus, the objective of this work was to evaluate the genetic diversity, agronomic potential and downy mildew reaction in biofortified mini lettuce genotypes. The experiment was carried out in the Un.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039939

DOI: http://dx.doi.org/10.4238/gmr16039939

Glioblastoma in a 20-year-old female patient after Chikungunya infection

Authors: L.O. Mourão, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves

We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX positive, Ki-67 positive in 35% of neoplast.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039941

DOI: http://dx.doi.org/10.4238/gmr16039941

Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer

Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy

    Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer development and progression. Setting: National cancer instit.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039942

DOI: http://dx.doi.org/10.4238/gmr16039942

Relationship between melanoma-associated antigen 1 (MAGE-A1) gene polymorphisms and colorectal cancer development

Authors: Mikhlid Almutairi and Abdelhabib Semlali

In the Saudi population, colorectal cancer (CRC) is the first and third most common malignancy among males and females, respectively. The CRC risk is associated with the expression of certain genes, which can be used for prognoses and for finding screening-related biomarkers. One such gene is melanoma-associated antigen 1 (MAGE-A1); however, little is known about this gene or its expression as .. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039940

DOI: http://dx.doi.org/10.4238/gmr16039940

NNT and NNT-AS1 expression levels are not different between bipolar patients and healthy subjects

Authors: Soudeh Ghafouri-Fard, Mohammad Taheri, Vahid Kholghi Oskooie, Mir Davood Omrani, Arezou Sayad

Nicotinamide nucleotide transhydrogenase (NNT) participates in redox and energy interconnections. Nnt silencing in N27 dopaminergic cells has changed basal, extra, and greatest mitochondrial oxygen absorption rates and made these cell vulnerable to constant upsurges in H2O2. NNT-antisense RNA1 (NNT-AS1) is transcribed from the opposite stand of NNT gene and is possibly involved in regulation of.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039943

DOI: http://dx.doi.org/10.4238/gmr16039943

The clinical significance of miR-7-5p downregulation in gastric dysplasia and gastric cancer tissue

Authors: Sara Omrani, Ali Zare, Shahriar Tarighi, Hamid Ghaedi, Mir Davood Omrani

miRNAs have been involved in the pathogenesis of several cancers such as gastric cancer (GC.). In the following study we analyzed the expression of miR-7 in gastric cancer samples compared non-tumor tissues and gastric dysplasia (GD) samples with patients’ clinico-pathological data and its potential as diagnostic biomarker. We first analyzed its expression by real-time qRT– PCR in h.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039944

DOI: http://dx.doi.org/10.4238/gmr16039944

Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer

Authors: Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard

Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues (ANCTs) to find their putative role in .. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039945

DOI: http://dx.doi.org/10.4238/gmr16039945

Integrative omics of ovarian cancer

Authors: Yanisa Rattanapan and Takol Chareonsirisuthigul

Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of cancer are the continual debate. Due to t.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039946

DOI: http://dx.doi.org/10.4238/gmr16039946

Expression analysis of OIP5-AS1 in bladder tissues

Authors: Feraydoon Abdolmaleki, Soudeh Ghafoui-Fard, Mohammad Taheri, Alireza Mordadi, Mandana Afasharpad, Abolghasem Nikfallah, Bashir Nazparvar, Vahid Kholghi Oskooei, Mir Davood Omrani

Long non-coding RNAs (lncRNAs) have crucial roles in regulation of many aspects of cell functions which are related with carcinogenesis process. The lncRNA Opa Interacting Protein 5-antisense 1 (OIP5-AS1) is among lncRNAs whose roles in some human malignancies have been elucidated. In the current study, we aimed at identification of the role of this lncRNA in bladder cancer. Expression level of.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039947

DOI: http://dx.doi.org/10.4238/gmr16039947

Molecular insights of mitochondrial 16S rDNA genes of the native honey bees subspecies Apis mellifera carnica and Apis mellifera jementica (Hymenoptera: Apidae) in Saudi Arabia

Authors: Reem Alajmi, Rewaida Abdel-Gaber, Loloa Alfozana

The honey bee Apis mellifera is of major importance for the world’s agriculture and is also suitable for environmental monitoring. It includes several recognized subspecies distinguished by using morphological and morphometric variants. Here, 200 adult worker Apis mellifera honey bees were collected from Hail region, Saudi Arabia. Mitochondrial 16S rDNA was conducted to detect molecular p.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039948

DOI: http://dx.doi.org/10.4238/gmr16039948

Possible association of proinflammatory cytokine IL-19 gene polymorphism with psoriasis

Authors: Wani Aadil, Bashir Ahmad Ganai, Tahseena Akhtar Tarun Narang, Rajinder Kaur

Background: Interleukin (IL-19) a member of the IL-10 family involved in abnormal keratinocyte differentiation and proliferation which is the hall mark of psoriasis. Aim: The aim of this study was to investigate the association between IL-19 gene polymorphism in patients with chronic plaque psoriasis as a factor in the susceptibility and development of psoriasis. Subjects and Me.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039949

DOI: http://dx.doi.org/10.4238/gmr16039949

Potential Protective Effect of Vitamin D on Cardiac Extrinsic pathways of apoptosis in Male Rats Fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zainab Al-refaie, Hossam Awad, Mahmood Rasool

Background: Obesity and vitamin D deficiency are increasing in Kingdom of Saudi Arabia (KSA) in last decades. Researchers have shown a relation between both disorders and cardiovascular disease (CVD). The present work aimed to investigate the possible protective effect of vitamin D on cardiac apoptosis in rats fed with a high fat diet. Methods: This study included 30 male wistar rats and was di.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039950

DOI: http://dx.doi.org/10.4238/gmr16039950

Super Canola: Newly Developed High Yielding, Lodging and Drought Tolerant Double Zero Cultivar of Rapeseed (Brassica napus L.)

Authors: Tariq Mahmood, Hafiz Saad Bin Mustafa, Muhammad Aftab, Qurban Ali and Arif Malik

The aim of present research was to develop a high yielding rapeseed cultivar having good quantitative and qualitative characteristics under the scenario of climate change. The research was initiated during 2005 and successfully completed during 2018 by Oilseeds Research Institute, Faisalabad Pakistan. Super Canola (RBN-13018) is an outcome of hybridization (Rainbow × RBN-03052) in 2005-06.. Read More»

Genet. Mol. Res. 18(2): http://dx.doi.org/gmr16039951

DOI: http://dx.doi.org/10.4238/gmr16039951

Diabetes mellitus types: Key genetic determinants and risk assessment

Authors: Dhilleswara Rao Vana, Dattatreya Adapa, Prasad VSS, Amarendranath Choudhury

The characteristic symptom of diabetes is consistently elevated levels of blood sugar. This is instigated either by complete lack of insulin production (type 1 diabetes), reduced level of insulin production (type 2 diabetes) or insulin resistance (inability of body cells to take up glucose). Other types of diabetes include maturity onset of diabetes of the young (MODY), a form of type 2 diabete.. Read More»

Genet. Mol. Res. 18(2): http://dx.doi.org/gmr16039952

DOI: http://dx.doi.org/10.4238/gmr16039952

Adrenomedullin gene polymorphisms (rs4399321A/G and rs4910118C/T) in pregnancy related disorder: Preeclampsia

Authors: Goske Deepthi, Komaravalli Prasanna Latha, Vital Usharani, Prof. P. Fazul Rahman, Parveen Jahan

Preeclampsia (PE), a pregnancy specific vascular disorder which is characterized by hypertension and proteinuria is a leading cause of maternal, fetal/neonatal morbidity and mortality affecting 5-14% of pregnancies. PE is a multifactorial disorder associated with poor placentation, placental hypoxia, poor angiogenesis and excessive maternal inflammation. Adrenomedullin (ADM) is a multi.. Read More»

Genet. Mol. Res. 18(2): http://dx.doi.org/gmr16039953

DOI: http://dx.doi.org/10.4238/gmr16039953

Digital image analysis to quantify genetic divergence in passion fruit seeds

Authors: Leandro Rafael Fachi, Willian Krause, Henrique Duarte Vieira, Dejânia Vieira de Araújo, Petterson Baptista da Luz, Alexandre Pio Viana

Phenotyping through digital images has been used to evaluate morphological characteristics of seeds, providing fast, accurate results. The objective of this work was to estimate the genetic divergence among full-sibling families of passion fruit through morphophysiological characteristics of seeds using the Ward-MLM method. Seeds of 98 full-sibling families (FSF) of passion fruit from the breed.. Read More»

Genet. Mol. Res. 18(2):

Synonymous Variant of ACE Gene (rs4343) is Coupled with Early Age at Onset and Diminished Diabetic Duration in South Indian Diabetic Nephropathy Patients

Authors: S. Babi Heera, Umme Najiya Mahwish, Fazul Rahman, Sayeeduddin S, Sree Bhushan Raju , Parveen Jahan

Diabetic nephropathy (T2DN) is a major micro vascular complication associated with type-2 diabetes (T2DM). Abnormally active Renin Angiotensin System pathway is shown to influence the development of T2DN and the inter-individual variation with respect to ACE levels, a key enzyme in this pathway partly dependent on the genetic variants of ACE; suggests patient’s genotype may influence the .. Read More»

Genet. Mol. Res. 17(2):

Protective effect of Vitamin D on Cardiac Mitochondrial Apoptotic pathway in Rats fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zienab Alrefaie, Hossam Awad

Background: Both diet quality and vitamin D status are important factors associated with many cardiovascular risk factors. Cardiac mitochondrial pathway of apoptosis has been associated with those factors. The current work aimed to assess the effect of chronic consumption of high fat diet (HFD) on the cardiac markers of mitochondrial pathway of apoptosis and whether vitamin D supplementation wi.. Read More»

Genet. Mol. Res. 18(2):