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Human Genetics   Research Article

Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer

Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy

Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer .. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Research Article

Synonymous Variant of ACE Gene (rs4343) is Coupled with Early Age at Onset and Diminished Diabetic Duration in South Indian Diabetic Nephropathy Patients

Authors: S. Babi Heera, Umme Najiya Mahwish, Fazul Rahman, Sayeeduddin S, Sree Bhushan Raju , Parveen Jahan

Diabetic nephropathy (T2DN) is a major micro vascular complication associated with type-2 diabetes (T2DM). Abnormally active Renin Angiotensin System pathway is shown to influence the development of T2DN and the inter-individual variation with respect to ACE levels, a key enzyme in this pathway partly dependent on the genetic variants of ACE.. Read More»

Genet. Mol. Res. 18(2):
Human Genetics   Review Article

Integrative omics of ovarian cancer

Authors: Yanisa Rattanapan and Takol Chareonsirisuthigul

Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of c.. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Research Article

Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer

Authors: Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard

Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues.. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Research Article

Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer

Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali

Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R g.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039935
DOI:
http://dx.doi.org/10.4238/gmr16039935
Human Genetics   Research Article

MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection

Authors: Patricia Milhoransa, Carolina Caruccio Montanari, Mariane Dos Santos, Marina Sieber, Roberto Ceratti Manfro

Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has man.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039933
DOI:
http://dx.doi.org/10.4238/gmr16039933
Human Genetics   Research Article

Selection of resistance sources to common bean anthracnose by field phenotyping and DNA marker-assisted screening

Authors: A.F. Vieira, L.C.S. Almeida, L.A. Rodrigues, J.G.C. Costa, L.C. Melo, H.S. Pereira, D.A. Sanglard and T.L.P.O. Souza

The main goal of this work was to select resistance sources to common bean anthracnose by field phenotyping and DNA marker-assisted screening. Fifty-five common bean genotypes, including differential varieties, characterized resistance sources, elite lines, cultivars and controls, were evaluated in a field inoculation trial an.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18066
DOI:
http://dx.doi.org/10.4238/gmr18066
Human Genetics   Research Article

CD40 rs4810485 T>G polymorphism and susceptibility to ankylosing spondylitis in the Latvian population

Authors: J. Zepa, L. Silamiķele, I. Bulina, V. Lavrentjevs, I. Trapina, J. Klovins, D. Andersone, A. Lejnieks and L. Nikitina-Zake

Ankylosing spondylitis (AS) is a potentially disabling form of a systemic chronic inflammatory arthritis affecting mainly the axial skeleton, with or without extraspinal manifestations. The genetic basis of AS is partly known. Moreover, many autoimmunityrelated genes have pleiotropic effects. Multiple functional polymorphisms .. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18081
DOI:
http://dx.doi.org/10.4238/gmr18081
Human Genetics   Research Article

Genetic structure and diversity of Senefeldera verticillata (Euphorbiaceae) in semideciduous seasonal forest fragments

Authors: A.A.R. Vieira, A.L. Silva Júnior, L.C. Souza, F.D. Miranda, M.F.S. Ferreira and M.V.W. Caldeira

Senefeldera verticillata (Euphorbiaceae) is a species that exclusively occurs in the Atlantic Forest; it is used in the restoration and recovery of degraded areas and has therapeutic uses. Due to the scarcity of information on genetic patterns of this species, genetic diversity was characterized by the use of molecular markers.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18059
DOI:
http://dx.doi.org/10.4238/gmr18059
Human Genetics   Research Article

Effect of the PLAG1 gene polymorphism on oleic acid percentage in Japanese Black cattle populations

Authors: H. Kigoshi, F. Kawaguchi, R. Yasuzumi, K. Oyama, H. Mannen, S. Sasazaki

We investigated the effect of the PLAG1 gene (on bovine chromosome 14) polymorphism on oleic acid percentage (C18:1) in four Japanese Black cattle populations (JB1: n = 900, JB2: n = 560, JB3: n = 456, JB4: n = 450). We genotyped the PLAG1 polymorphism (rs109231213) for four populations and then analyzed the effects on carcass.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18056
DOI:
http://dx.doi.org/10.4238/gmr18056