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Human Genetics   Research Article

Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer

Authors: Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard

Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues.. Read More»

Genet. Mol. Res. 18(1):
http://dx.doi.org/gmr16039945
DOI:
http://dx.doi.org/10.4238/gmr16039945
Human Genetics   Research Article

Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer

Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali

Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R g.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039935
DOI:
http://dx.doi.org/10.4238/gmr16039935
Human Genetics   Research Article

MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection

Authors: Patricia Milhoransa, Carolina Caruccio Montanari, Mariane Dos Santos, Marina Sieber, Roberto Ceratti Manfro

Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has man.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039933
DOI:
http://dx.doi.org/10.4238/gmr16039933
Human Genetics   Research Article

Selection of resistance sources to common bean anthracnose by field phenotyping and DNA marker-assisted screening

Authors: A.F. Vieira, L.C.S. Almeida, L.A. Rodrigues, J.G.C. Costa, L.C. Melo, H.S. Pereira, D.A. Sanglard and T.L.P.O. Souza

The main goal of this work was to select resistance sources to common bean anthracnose by field phenotyping and DNA marker-assisted screening. Fifty-five common bean genotypes, including differential varieties, characterized resistance sources, elite lines, cultivars and controls, were evaluated in a field inoculation trial an.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18066
DOI:
http://dx.doi.org/10.4238/gmr18066
Human Genetics   Research Article

CD40 rs4810485 T>G polymorphism and susceptibility to ankylosing spondylitis in the Latvian population

Authors: J. Zepa, L. Silamiķele, I. Bulina, V. Lavrentjevs, I. Trapina, J. Klovins, D. Andersone, A. Lejnieks and L. Nikitina-Zake

Ankylosing spondylitis (AS) is a potentially disabling form of a systemic chronic inflammatory arthritis affecting mainly the axial skeleton, with or without extraspinal manifestations. The genetic basis of AS is partly known. Moreover, many autoimmunityrelated genes have pleiotropic effects. Multiple functional polymorphisms .. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18081
DOI:
http://dx.doi.org/10.4238/gmr18081
Human Genetics   Research Article

Genetic structure and diversity of Senefeldera verticillata (Euphorbiaceae) in semideciduous seasonal forest fragments

Authors: A.A.R. Vieira, A.L. Silva Júnior, L.C. Souza, F.D. Miranda, M.F.S. Ferreira and M.V.W. Caldeira

Senefeldera verticillata (Euphorbiaceae) is a species that exclusively occurs in the Atlantic Forest; it is used in the restoration and recovery of degraded areas and has therapeutic uses. Due to the scarcity of information on genetic patterns of this species, genetic diversity was characterized by the use of molecular markers.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18059
DOI:
http://dx.doi.org/10.4238/gmr18059
Human Genetics   Research Article

Effect of the PLAG1 gene polymorphism on oleic acid percentage in Japanese Black cattle populations

Authors: H. Kigoshi, F. Kawaguchi, R. Yasuzumi, K. Oyama, H. Mannen, S. Sasazaki

We investigated the effect of the PLAG1 gene (on bovine chromosome 14) polymorphism on oleic acid percentage (C18:1) in four Japanese Black cattle populations (JB1: n = 900, JB2: n = 560, JB3: n = 456, JB4: n = 450). We genotyped the PLAG1 polymorphism (rs109231213) for four populations and then analyzed the effects on carcass.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18056
DOI:
http://dx.doi.org/10.4238/gmr18056
Human Genetics   Research Article

Infertility caused by an association between Arg72Pro polymorphism of the p53 gene and Glu298Asp of the eNOS gene in patients with endometriosis

Authors: T.R. Santos, K.S.F. e Silva, R.C.P.C. Silva, K.K.V.O. Moura, L.A. Guillo, C.L. Ribeiro Júnior and I.R. Costa

Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tiss.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18046
DOI:
http://dx.doi.org/10.4238/gmr18046
Human Genetics   Research Article

High precision experimental statistics for the selection of common bean lines that have superior agronomic performance

Authors: N.D. Ribeiro, S. de M. Steckling and H.C. Mezzomo

The identification of a single statistic that allows selection of superior genotypes for several agronomic traits with high experimental precision would be useful for bean breeding programs. We examined correlations between 12 statistics for agronomic traits to determine which would be useful for the selection of common bean l.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18042
DOI:
http://dx.doi.org/10.4238/gmr18042
Human Genetics   Research Article

Detection of sequences related to biosynthesis of antifungal metabolites and identification of a PhzF-like gene in a Pseudomonas rhizobacterium of Piper tuberculatum

Authors: O.S. Silva Jr., N.L.F. Barros, A.S. Siqueira, E.C. Gonçalves, D. N. Marques, S.P. Reis, and C.R.B. Souza

Our previous studies identified a Pseudomonas putida (Pt12 isolate) associated with roots of Piper tuberculatum Jacq., a Piperaceae occurring in the Amazon region with known resistance to infection by Fusarium solani f. sp. piperis, the causal agent of root rot disease in black pepper (Piper nigrum L.). This Pt12 isolate was a.. Read More»

Genet. Mol. Res. 17(3):
http://dx.doi.org/gmr18035
DOI:
http://dx.doi.org/10.4238/gmr18035