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Human Genetics   Research Article

Targeted Delivery of Insulin by Psyllium Plant (Plantago ispaghula) based hydrogels/membranes

Authors: A.J. Sami, U. Ahmad, M. Karamat, M.N. Hafeez and Q. Ali

Developments in therapeutics are the need of hour for the benefit of mankind and to increase the quality of life. Diabetes mellitus is a non-curable disease affecting a great amount of world’s population. This genetic disorder gets worse with time and ultimately leads to various complications like renal failure, lower limb amputation, heart diseases.. Read More»

Genet. Mol. Res. 19(2):
Human Genetics   Editorials

Editorial Highlights for Journal of Genetics and Molecular Research

Authors: H. Sasi

I am pleased to mention that during the year 2019, all issues of volume 18 were published online well within the time and the print issues were also brought out and dispatched within 30 days of publishing the issue online. Genetics and Molecular Research (GMR) successfully released issues with 70 abstracts. The submissions to the journal are subjected to .. Read More»

Genet. Mol. Res. 19(2):
Human Genetics   Research Article

Evaluation of Genetic Variability in Wheat and Maize under Heavy Metal and Drought Stress

Authors: M. Tahir, M.S. Rashid, Q. Ali and A. Malik

There are certain conditions which cause a change in the growth pattern of plants. These circumstances are significantly effective in growth and cultivation of major crops. The effects of higher levels of copper sulphate through fertilizers can be effective in reducing the growth of a healthy plant. An experiment was conducted in the greenhouse of Institu.. Read More»

Genet. Mol. Res. 19(3):
Human Genetics   Research Article

Hepatitis B and C prevalence and its associated risk factors among school going children in urban and rural areas of District Muzaffar Garh, Pakistan

Authors: Sikandar Hayat, Muhammad Naeem, Arif Malik, Qurban Ali, Muhammad Khalid, Samrah Masud and Arif Mahmood Bhutta

Viral Hepatitis like hepatitis B and hepatitis C are the serious cause of mortality in Pakistan. Present study estimated the prevalence and risk factors associated with Hepatitis B and C among school going children from urban and rural areas. In urban areas overall prevalence of HBV was 5% where the highest prevalence of HBV was 80% and 20% in males and f.. Read More»

Genet. Mol. Res. 19(1):
Human Genetics   Research Article

Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer

Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy

Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer .. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Research Article

Electroporation induced membrane permeability changes at the ionic level

Authors: Sadasivam Pachamuthu, Zubin A Zaheer, Bhuvaneshwari Sampath, Dharani Muralidharan, Rajaprabu Ramachandran and Kavitha Sankaranarayanan

Background/Aim: Electrochemotherapy is an innovative method for the localized treatment of cutaneous and subcutaneous metastatic cancers. The aim of the study is to assess the changes at the plasma membrane and its recovery time by monitoring the regulated passage of ions through specific ion channels as measured by electrophysiology. Materials an.. Read More»

Genet. Mol. Res. 18(3):
Human Genetics   Review Article

Integrative omics of ovarian cancer

Authors: Yanisa Rattanapan and Takol Chareonsirisuthigul

Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of c.. Read More»

Genet. Mol. Res. 18(4):
Human Genetics   Research Article

Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer

Authors: Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard

Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues.. Read More»

Genet. Mol. Res. 18(3):
Human Genetics   Case Reports

Glioblastoma in a 20-year-old female patient after Chikungunya infection

Authors: L.O. Mourão, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves

We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX pos.. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Research Article

Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer

Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali

Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R g.. Read More»

Genet. Mol. Res. 17(4):


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