Human Genetics
Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer
Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy
Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer .. Read More»
- Genet. Mol. Res. 18(1):
Electroporation induced membrane permeability changes at the ionic level
Authors: Sadasivam Pachamuthu, Zubin A Zaheer, Bhuvaneshwari Sampath, Dharani Muralidharan, Rajaprabu Ramachandran and Kavitha Sankaranarayanan
Background/Aim: Electrochemotherapy is an innovative method for the localized treatment of cutaneous and subcutaneous metastatic cancers. The aim of the study is to assess the changes at the plasma membrane and its recovery time by monitoring the regulated passage of ions through specific ion channels as measured by electrophysiology. Materials an.. Read More»
- Genet. Mol. Res. 18(3):
Synonymous Variant of ACE Gene (rs4343) is Coupled with Early Age at Onset and Diminished Diabetic Duration in South Indian Diabetic Nephropathy Patients
Authors: S. Babi Heera, Umme Najiya Mahwish, Fazul Rahman, Sayeeduddin S, Sree Bhushan Raju , Parveen Jahan
Diabetic nephropathy (T2DN) is a major micro vascular complication associated with type-2 diabetes (T2DM). Abnormally active Renin Angiotensin System pathway is shown to influence the development of T2DN and the inter-individual variation with respect to ACE levels, a key enzyme in this pathway partly dependent on the genetic variants of ACE.. Read More»
- Genet. Mol. Res. 18(2):
Integrative omics of ovarian cancer
Authors: Yanisa Rattanapan and Takol Chareonsirisuthigul
Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of c.. Read More»
- Genet. Mol. Res. 18(4):
Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer
Authors: Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard
Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues.. Read More»
- Genet. Mol. Res. 18(3):
Glioblastoma in a 20-year-old female patient after Chikungunya infection
Authors: L.O. Mourão, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves
We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX pos.. Read More»
- Genet. Mol. Res. 18(1):
Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer
Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali
Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R g.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039935
- DOI:
- http://dx.doi.org/10.4238/gmr16039935
MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection
Authors: Patricia Milhoransa, Carolina Caruccio Montanari, Mariane Dos Santos, Marina Sieber, Roberto Ceratti Manfro
Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has man.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039933
- DOI:
- http://dx.doi.org/10.4238/gmr16039933
Selection of resistance sources to common bean anthracnose by field phenotyping and DNA marker-assisted screening
Authors: A.F. Vieira, L.C.S. Almeida, L.A. Rodrigues, J.G.C. Costa, L.C. Melo, H.S. Pereira, D.A. Sanglard and T.L.P.O. Souza
The main goal of this work was to select resistance sources to common bean anthracnose by field phenotyping and DNA marker-assisted screening. Fifty-five common bean genotypes, including differential varieties, characterized resistance sources, elite lines, cultivars and controls, were evaluated in a field inoculation trial an.. Read More»
- Genet. Mol. Res. 17(3):
- http://dx.doi.org/gmr18066
- DOI:
- http://dx.doi.org/10.4238/gmr18066
CD40 rs4810485 T>G polymorphism and susceptibility to ankylosing spondylitis in the Latvian population
Authors: J. Zepa, L. Silamiķele, I. Bulina, V. Lavrentjevs, I. Trapina, J. Klovins, D. Andersone, A. Lejnieks and L. Nikitina-Zake
Ankylosing spondylitis (AS) is a potentially disabling form of a systemic chronic inflammatory arthritis affecting mainly the axial skeleton, with or without extraspinal manifestations. The genetic basis of AS is partly known. Moreover, many autoimmunityrelated genes have pleiotropic effects. Multiple functional polymorphisms .. Read More»
- Genet. Mol. Res. 17(3):
- http://dx.doi.org/gmr18081
- DOI:
- http://dx.doi.org/10.4238/gmr18081