Human Genetics
Frequency of the hypervariable DNA loci D18S849, D3S1744, D12S1090 and D1S80 in a mixed ancestry population of Chilean blood donors
Authors: M. Acu�±a, H. Jorquera, L. Cifuentes and L. Armanet
Blood donors (N = 150) at San José Hospital (Santiago, Chile) were typed for one VNTR locus (D1S80) and three STR loci (D18S849, D3S1744, D12S1090). A questionnaire was used to determine the socioeconomic level of the donors, because it is known that some genetic markers (e.g., the ABO and Rh groups) are differentially .. Read More»
- Genet. Mol. Res. 1(2):
Molecular cytogenetics in metaphase and interphase cells for cancer and genetic research,diagnosis and prognosis. Application in tissue sections and cell suspensions
Authors: Maria M�¼hlmann
As the pioneer among molecular cytogenetics techniques, fluorescence in situ hybridization (FISH) allows identification of specific sequences in a structurally preserved cell, in metaphase or interphase. This technique, based on the complementary double-stranded nature of DNA, hybridizes labeled specific DNA (probe). The probe.. Read More»
- Genet. Mol. Res. 1(2):
Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress
Authors: Cristina Pungartnik, Jaqueline Picada, Martin Brendel and Jo�£o A.P. Henriques
The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substantiated their allocation into two distinct groups: genes PSO1 (allelic to REV3), PSO2 (SNM1), PSO4 (PRP19), and PSO5 (RAD16) const.. Read More»
- Genet. Mol. Res. 1(1):
Inheritance of resistance to the root-knot nematode Meloidogyne javanica in lettuce
Authors: Wilson Roberto Maluf, Sebasti�£o M�¡rcio Azevedo,Luiz Antonio Augusto Gomes and Ana Cl�¡udia Barneche de Oliveira
Resistance to the root-knot nematodes Meloidogyne spp. would be a valuable attribute of lettuce Lactuca sativa L. cultivars grown in tropical regions. The looseleaf lettuce ‘Grand Rapids’ is resistant to both M. incognita and M. javanica. Resistance to M. incognita has a high heritability, under the control of a si.. Read More»
- Genet. Mol. Res. 1(1):
The future of selection: individuality, the twin legacies of Lamarck & Darwin
Authors: Hugo Hoenigsberg
The different levels of biological hierarchy - genes, chromosomes, cells, species and communities - are different survival entities that require different heritable variations in fitness in order to function as units of selection in the evolutionary process. These entities have retained to varying degrees some of their primord.. Read More»
- Genet. Mol. Res. 1(1):
Cystic fibrosis in Uruguay
Authors: Gerardo Luzardo, Isabel Aznarez, Beatriz Crispino, Adriana Mimbacas, Liria MartÃ?Ânez, Rossana Poggio, Julian Zielenski, Lap-Chee Tsui and Horacio Cardoso
We conducted clinical and genetic analyses of 52 cystic fibrosis (CF) patients in Uruguay, which is about half of the known affected individuals in the country. A relatively high proportion had a mild presentation, characterized by pancreatic sufficiency (28%), a strong pulmonary component (97%), and borderline sweat electroly.. Read More»
- Genet. Mol. Res. 1(1):