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Table of contents: 2019 ( Volume 18, Issue 1 )
Plant Genetics   Research Article

Genetic inheritance of traits relating to seedling and size in ornamental pepper

Pepper exhibits genetic diversity and versatility in use. Knowledge of the genetic control of traits in peppers is of great importance to breeding programs given the variety of types, sizes, colors and flavors. The aim of the present study was to examine the inheritance of seedling and plant traits in ornamental pepper (Capsicum annuum). The experiment was conducted in a greenhouse in the plant.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039938

DOI: http://dx.doi.org/10.4238/gmr16039938

Plant Genetics   Research Article

Genetic diversity, agronomic potential and reaction to downy mildew in genotypes of biofortified mini lettuce

Lettuce is one of the most consumed leaf vegetables in the world, highlighting itself as a novelty in the market as mini type cultivars. During the winter the downy mildew can lead to severe damage. Thus, the objective of this work was to evaluate the genetic diversity, agronomic potential and downy mildew reaction in biofortified mini lettuce genotypes. The experiment was carried out in the Un.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039939

DOI: http://dx.doi.org/10.4238/gmr16039939

Human Genetics   Case Reports

Glioblastoma in a 20-year-old female patient after Chikungunya infection

We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX positive, Ki-67 positive in 35% of neoplast.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039941

DOI: http://dx.doi.org/10.4238/gmr16039941

Human Genetics   Research Article

Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer

    Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer development and progression. Setting: National cancer instit.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039942

DOI: http://dx.doi.org/10.4238/gmr16039942

Medical Genetics   Research Article

Relationship between melanoma-associated antigen 1 (MAGE-A1) gene polymorphisms and colorectal cancer development

In the Saudi population, colorectal cancer (CRC) is the first and third most common malignancy among males and females, respectively. The CRC risk is associated with the expression of certain genes, which can be used for prognoses and for finding screening-related biomarkers. One such gene is melanoma-associated antigen 1 (MAGE-A1); however, little is known about this gene or its expression as .. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039940

DOI: http://dx.doi.org/10.4238/gmr16039940

Medical Genetics   Research Article

NNT and NNT-AS1 expression levels are not different between bipolar patients and healthy subjects

Nicotinamide nucleotide transhydrogenase (NNT) participates in redox and energy interconnections. Nnt silencing in N27 dopaminergic cells has changed basal, extra, and greatest mitochondrial oxygen absorption rates and made these cell vulnerable to constant upsurges in H2O2. NNT-antisense RNA1 (NNT-AS1) is transcribed from the opposite stand of NNT gene and is possibly involved in regulation of.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039943

DOI: http://dx.doi.org/10.4238/gmr16039943

Medical Genetics   Research Article

The clinical significance of miR-7-5p downregulation in gastric dysplasia and gastric cancer tissue

miRNAs have been involved in the pathogenesis of several cancers such as gastric cancer (GC.). In the following study we analyzed the expression of miR-7 in gastric cancer samples compared non-tumor tissues and gastric dysplasia (GD) samples with patients’ clinico-pathological data and its potential as diagnostic biomarker. We first analyzed its expression by real-time qRT– PCR in h.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039944

DOI: http://dx.doi.org/10.4238/gmr16039944

Human Genetics   Review Article

Integrative omics of ovarian cancer

Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of cancer are the continual debate. Due to t.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039946

DOI: http://dx.doi.org/10.4238/gmr16039946

Medical Genetics   Research Article

Expression analysis of OIP5-AS1 in bladder tissues

Long non-coding RNAs (lncRNAs) have crucial roles in regulation of many aspects of cell functions which are related with carcinogenesis process. The lncRNA Opa Interacting Protein 5-antisense 1 (OIP5-AS1) is among lncRNAs whose roles in some human malignancies have been elucidated. In the current study, we aimed at identification of the role of this lncRNA in bladder cancer. Expression level of.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039947

DOI: http://dx.doi.org/10.4238/gmr16039947

Animal Genetics   Research Article

Molecular insights of mitochondrial 16S rDNA genes of the native honey bees subspecies Apis mellifera carnica and Apis mellifera jementica (Hymenoptera: Apidae) in Saudi Arabia

The honey bee Apis mellifera is of major importance for the world’s agriculture and is also suitable for environmental monitoring. It includes several recognized subspecies distinguished by using morphological and morphometric variants. Here, 200 adult worker Apis mellifera honey bees were collected from Hail region, Saudi Arabia. Mitochondrial 16S rDNA was conducted to detect molecular p.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039948

DOI: http://dx.doi.org/10.4238/gmr16039948

Medical Genetics   Research Article

Possible association of proinflammatory cytokine IL-19 gene polymorphism with psoriasis

Background: Interleukin (IL-19) a member of the IL-10 family involved in abnormal keratinocyte differentiation and proliferation which is the hall mark of psoriasis. Aim: The aim of this study was to investigate the association between IL-19 gene polymorphism in patients with chronic plaque psoriasis as a factor in the susceptibility and development of psoriasis. Subjects and Me.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039949

DOI: http://dx.doi.org/10.4238/gmr16039949

Animal Genetics   Research Article

Potential Protective Effect of Vitamin D on Cardiac Extrinsic pathways of apoptosis in Male Rats Fed with high fat diet

Background: Obesity and vitamin D deficiency are increasing in Kingdom of Saudi Arabia (KSA) in last decades. Researchers have shown a relation between both disorders and cardiovascular disease (CVD). The present work aimed to investigate the possible protective effect of vitamin D on cardiac apoptosis in rats fed with a high fat diet. Methods: This study included 30 male wistar rats and was di.. Read More»

Genet. Mol. Res. 18(1): http://dx.doi.org/gmr16039950

DOI: http://dx.doi.org/10.4238/gmr16039950

Table of contents: 2019 ( Volume 18, Issue 2 )
Plant Genetics   Research Article

Super Canola: Newly Developed High Yielding, Lodging and Drought Tolerant Double Zero Cultivar of Rapeseed (Brassica napus L.)

The aim of present research was to develop a high yielding rapeseed cultivar having good quantitative and qualitative characteristics under the scenario of climate change. The research was initiated during 2005 and successfully completed during 2018 by Oilseeds Research Institute, Faisalabad Pakistan. Super Canola (RBN-13018) is an outcome of hybridization (Rainbow × RBN-03052) in 2005-06.. Read More»

Genet. Mol. Res. 18(2): http://dx.doi.org/gmr16039951

DOI: http://dx.doi.org/10.4238/gmr16039951

Human Genetics   Research Article

Diabetes mellitus types: Key genetic determinants and risk assessment

The characteristic symptom of diabetes is consistently elevated levels of blood sugar. This is instigated either by complete lack of insulin production (type 1 diabetes), reduced level of insulin production (type 2 diabetes) or insulin resistance (inability of body cells to take up glucose). Other types of diabetes include maturity onset of diabetes of the young (MODY), a form of type 2 diabete.. Read More»

Genet. Mol. Res. 18(2): http://dx.doi.org/gmr16039952

DOI: http://dx.doi.org/10.4238/gmr16039952

Human Genetics   Research Article

Adrenomedullin gene polymorphisms (rs4399321A/G and rs4910118C/T) in pregnancy related disorder: Preeclampsia

Preeclampsia (PE), a pregnancy specific vascular disorder which is characterized by hypertension and proteinuria is a leading cause of maternal, fetal/neonatal morbidity and mortality affecting 5-14% of pregnancies. PE is a multifactorial disorder associated with poor placentation, placental hypoxia, poor angiogenesis and excessive maternal inflammation. Adrenomedullin (ADM) is a multi.. Read More»

Genet. Mol. Res. 18(2): http://dx.doi.org/gmr16039953

DOI: http://dx.doi.org/10.4238/gmr16039953

Plant Genetics   Research Article

Digital image analysis to quantify genetic divergence in passion fruit seeds

Phenotyping through digital images has been used to evaluate morphological characteristics of seeds, providing fast, accurate results. The objective of this work was to estimate the genetic divergence among full-sibling families of passion fruit through morphophysiological characteristics of seeds using the Ward-MLM method. Seeds of 98 full-sibling families (FSF) of passion fruit from the breed.. Read More»

Genet. Mol. Res. 18(2):

Human Genetics   Research Article

Synonymous Variant of ACE Gene (rs4343) is Coupled with Early Age at Onset and Diminished Diabetic Duration in South Indian Diabetic Nephropathy Patients

Diabetic nephropathy (T2DN) is a major micro vascular complication associated with type-2 diabetes (T2DM). Abnormally active Renin Angiotensin System pathway is shown to influence the development of T2DN and the inter-individual variation with respect to ACE levels, a key enzyme in this pathway partly dependent on the genetic variants of ACE; suggests patient’s genotype .. Read More»

Genet. Mol. Res. 18(2):

Animal Genetics   Research Article

Protective effect of Vitamin D on Cardiac Mitochondrial Apoptotic pathway in Rats fed with high fat diet

Background: Both diet quality and vitamin D status are important factors associated with many cardiovascular risk factors. Cardiac mitochondrial pathway of apoptosis has been associated with those factors. The current work aimed to assess the effect of chronic consumption of high fat diet (HFD) on the cardiac markers of mitochondrial pathway of apoptosis and whether vitamin D s.. Read More»

Genet. Mol. Res. 18(2):

Plant Genetics   Research Article

Dynamism of the breeding program for irrigated rice in Southeast Brazil

The estimation of the genotypic replacement rate is aimed at evaluating the performance of breeding programs. Thus, the objective of this study was to evaluate the dynamics of the genetic improvement program of flooded rice, developed in Minas Gerais, during the period from 1993 to 2016. We evaluated 210 lines in three environments between 1993 and 2016, in blocks, ranging from three to four re.. Read More»

Genet. Mol. Res. 18(2):

Medical Genetics   Research Article

Expression of HCN and sodium channels in murine model of Type I diabetes

Pancreatic apoptosis is an important event in the pathogenesis of Type 1 Diabetes. It is characterized by secretion and binding of inflammatory cytokines to the pancreatic islets, that activate downstream signaling mechanism. These signaling mechanisms finally increase intracellular calcium level and that lead to the activation of apoptotic pathways. Ion channels are transmembrane protein, resp.. Read More»

Genet. Mol. Res. 18(2):

Animal Genetics   Research Article

Development and characterization of microsatellite molecular markers for the eye mask frog Batrachyla taeniata (Girard, 1855)

Batrachyla taeniata (Batrachylidae) is a small frog from Chile and Argentina with a distributional range that spans more than 1500 km. However, their populations are threatened due to the change in land use, deforestation, and human settlements. Through massive sequencing runs in ION Torrent PGM, was built DNA fragment library, from which we finally isolated and characterized 25 micros.. Read More»

Genet. Mol. Res. 18(2):

Microbial Genetics   Research Article

Differential expression of genes associated with low-level vancomycin resistance in Staphylococcus aureus

Heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) have been associated with treatment failure, and hVISA cannot be detected by routine disc diffusion test. Currently, there is no specific genetic marker for detection of these strains. The aim of the current study was to investigate the differential expression of si.. Read More»

Genet. Mol. Res. 18(2):

Table of contents: 2019 ( Volume 18, Issue 3 )
Human Genetics   Research Article

Relation between MTHFR (Methylenetetrahydrofolate Reductase) gene functional polymorphisms and magnitude of Recurrent Pregnancy Losses (RPL) among women with low socio-economic status in Asian Indians

The present study was intended to investigate the role of MTHFR gene functional polymorphisms, rs1801133 (C677T) and rs1801131 (A1298C) in the susceptibility and severity of Recurrent Pregnancy Losses (RPLs) in women with low socio-economic status among Asian Indians. We screened a total of 221 women that includes 102 RPL patients and 119 healthy controls. Following DNA isolat.. Read More»

Genet. Mol. Res. 18(3):

Human Genetics   Research Article

Exome Sequencing Studies for Kids with Non-Familial Food Allergy

Introduction: Food allergies (FA) have been increasing dramatically over the past 25 years and the peanut allergy has been noticed more likely for a half-decade as well. The prevalence of FA in children was found to be 10%, which is high compared with adults. Limited periodic reports are available of numerous food allergic reactions in children. Complete exome sequencing in thi.. Read More»

Genet. Mol. Res. 18(3):

Animal Genetics   Research Article

Novel polymorphisms in the PLIN2 gene of Nellore cattle

Genetic variations in genes involved in lipid storage, which also may interfere with important phenotypic traits such as intramuscular fat deposition in cattle, can represent useful markers in marker assisted selection programs. An important candidate gene is perilipin 2 (PLIN2) that plays a role in the capture of long chain fatty acids and in the formation and stabilization of lipid d.. Read More»

Genet. Mol. Res. 18(3):

Plant Genetics   Research Article

Behavior of soybean genotypes in three locations in the Triângulo Mineiro

Soy is an important legume for global economy. The objectives of this study were evaluated soybean genotypes in different growing environments as for their agronomic characters and resistance to leaf spots, and determine the adaptability and phenotypic stability of materials in relation to the place of cultivation. Experiments were conducted in the cities of São Gotardo, Uberaba and Uber.. Read More»

Genet. Mol. Res. 18(3):

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