Table of contents: 2018 ( Volume 17, Issue 4 )
Microbial Genetics   Research Article

High concentrations of sacharose lead to metabolic changes that favor the formation of co-products in ethanolic fermentation by Zymomonas mobilis

Z. mobilis has attracted great biotechnology interest in recent decades due to its unique metabolism and the ability to produce bioethanol from simple sugars in an effectively and quickly way. Z. mobilis also produce other bioactive products as fructose, gluconic acid, sorbitol, levan, fructo-oligosaccharides. This study aimed to identify proteins differentially expressed by Z. mobilis ZAG-12 u.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039929

DOI: http://dx.doi.org/10.4238/gmr16039929

Medical Genetics   Research Article

Determination of CEBPA mutations in pediatric acute leukemia

The CCAAT/enhancer-binding protein-alpha (CEBPA) is lineage-specific transcription factor in the hematopoietic system. Several studies have reported the presence and frequency of CEBPA mutations.In this study, we aimed the clinical features and the prognostic significance associated with CEBPA mutations in 30 pediatric patients with acute leukemia.In addition, association between found variants.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039936

DOI: http://dx.doi.org/10.4238/gmr16039936

Animal Genetics   Research Article

Estimative of genetic diversity in germ-plasm of elephant grass using the Gower algorithm

This work aimed at estimating the genetic divergence among 85 accessions of elephant-grass using the Gower algorithm for the joint study of quantitative and qualitative traits. The experiment was conducted in the city of Campos dos Goytacazes, Rio de Janeiro state, Brazil, with of 85 elephant-grass genotypes. It was applied a randomized block experimental design with two replications. The exper.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039934

DOI: http://dx.doi.org/10.4238/gmr16039934

Plant Genetics   Research Article

Genetic variability in morphological characters among Fig tree accessions Fig genetic conservation

Fig is among the twenty main fruits exported by Brazil, which is the eighth largest producer of fig in natura in the world. The characterization of active germplasm banks (AGBs) of fig has thus become an important line of research, as it is necessary to gather information from this to carry out adequate management projects. The objective of this study was to characterize the morphologies of 42 .. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039931

DOI: http://dx.doi.org/10.4238/gmr16039931

Human Genetics   Research Article

MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection

Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has many limitations including risk and cost. T.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039933

DOI: http://dx.doi.org/10.4238/gmr16039933

Plant Genetics   Research Article

AtBTH1, a BTB domain-containing protein, influences sugar-responsive germination and seedling growth in Arabidopsis

Sugars function as signal molecules that regulate gene expression, growth, and development in plants, animals, and yeasts. As a contribution to understanding the molecular mechanisms of sugar responses, we identified and characterized an Arabidopsis thaliana BTB domain-containing protein of the H subfamily 1 (designated AtBTH1). The relative expression level of AtBTH1 was enhanced by exogenous .. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039932

DOI: http://dx.doi.org/10.4238/gmr16039932

Human Genetics   Research Article

Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer

Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R gene (rs1053496 and rs12516866) are corre.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039935

DOI: http://dx.doi.org/10.4238/gmr16039935

Medical Genetics   Research Article

Investigation of the role of apoptosis, necroptosis and DNA damage signaling pathways in multiple sclerosis

Multiple sclerosis (MS) as the most common autoimmune disorder in the central nervous system is a major health problem. MS is a complex disease with multiple environmental and genetic factors participating in it. In the present study, we evaluated the expression of 3 genes named BCL2, CASP2 and CASP8 in peripheral blood of 50 MS patients and 50 healthy controls to investigate the role of apopto.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039937

DOI: http://dx.doi.org/10.4238/gmr16039937

Medical Genetics   Review Article

Long non-coding RNA-protein interaction: the preliminary step to track their biological functions

RNA is not only an intermediate for the flow of genetic information between DNA and protein. The transcription of the entire genomes generates a myriad non-protein coding RNA in addition to protein coding genes. Among these transcripts, lncRNA which is the least well understood and they cannot be considered as merely transcriptional noises. Here, we review the emerging role of lncRNA interactio.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039920

DOI: http://dx.doi.org/10.4238/gmr16039920

Animal Genetics   Research Article

Comparing KISS1 and GPR54 genes between the two breeds of goats with low and high prolificacy

There is increasing evidence that kisspeptin, the peptide product of KISS1 gene and its receptor (GPR54), regulate reproductive processes through actions on other organs than hypothalamus. Therefore, the study for the first time, was conducted to investigate the nucleotide sequences and mRNA expression levels of KISS1 and GPR54 genes in pituitary, endometrium, ovary and oviduct of prolific Jint.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039922

DOI: http://dx.doi.org/10.4238/gmr16039922

Medical Genetics   Research Article

Association of ACE I/D, AT1R A1166C, CYP11B2 C344T polymorphism with essential hypertension in Asia: A meta-analysis

Aim: To evaluate the association between ACE I/D, AT1R A11166C, CYP11B2 C344T gene polymorphisms and the risk of EH in Asia. Materials and Methods: Related case-control studies were collected, selected and screened; a meta-analysis was conducted to assess the association between polymorphism of target genes and essential hypertension. Results: 41 articles were included. Among them, 17 studie.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039923

DOI: http://dx.doi.org/10.4238/gmr16039923

Plant Genetics   Research Article

Genetic diversity and population structure of ancient Platycladus orientalis (Cupressaceae) in the Mausoleum of the Yellow Emperor revealed by SSR

Ancient trees can serve as genetic reservoirs for special genes, and they are of significance in genetic applications dealing with forest fragmentation, climate change and drought. The Mausoleum of the Yellow Emperor in Shaanxi China has the largest number of ancient Platycladus orientalis trees. Here, Simple sequence repeat (SSR) technique was used to study the genetic diversity of ancient P. .. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039924

DOI: http://dx.doi.org/10.4238/gmr16039924

Plant Genetics   Research Article

DNA Extraction from silica gel preserved common bean (Phaseolus vulgaris L.) leaves

Extraction of high-quality DNA from field specimen requires collection under liquid nitrogen which is not readily available in resource constrained laboratories in low- and middle-income countries (LMICs). A method of extracting DNA from silica gel preserved common bean (Phaseolus vulgaris L.) leaves is presented. Our method which does not involve the use of phenol, chloroform or isoamyl alcoho.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039926

DOI: http://dx.doi.org/10.4238/gmr16039926

Plant Genetics   Research Article

Genetic damage in Mexican and South American sweet corn varieties due to the use of herbicides (Nicosulfuron and Topramezone)

In order to encourage corn production, several herbicides such as nicosulfuron and topramezone are used. Though they offer great advantages, they may affect crop productivity and may even induce DNA damage. This study evaluated genotoxic activity at two nicosulfuron concentrations (40,000 and 80, 000 ppm) and at four topramezone concentrations (1480, 148, 14.8 and 1.48 ppm) in sweet corn and hy.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039921

DOI: http://dx.doi.org/10.4238/gmr16039921

Plant Genetics   Research Article

Analysis of the molecular diversity of R. solani isolates from five Ugandan agro-ecological zones using inter - simple sequence repeat markers

This study used seven inter-simple sequence repeat (ISSR) markers to characterize 55 R. solani isolates in order to establish their genetic diversity. The isolates were from five common bean growing agro-ecological zones of Uganda; the Southwest highlands (SW), Lake Victoria crescent and Mbale farmlands (LVC), Teso farming system (TFS), the Northern mixed farmlands (N) and the Western highlands.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039927

DOI: http://dx.doi.org/10.4238/gmr16039927

Animal Genetics   Research Article

Genetic variants in exon 1 region of FABP3 gene in relation to milk production traits in Sahiwal and Karan Fries cattle

The present study pertained to records on milk production and milk constituents of 100 Sahiwal cattle and 115 Karan Fries cattle, the data collected over a period of 2004 to 2016 from Animal Genetics and Breeding division from ICAR-National Dairy Research Institute, Karnal, Haryana. In Sahiwal SNP at position G649C was found to be highly associated with FLTMY and FL305DFY and however the associ.. Read More»

Genet. Mol. Res. 17(4): http://dx.doi.org/gmr16039928

DOI: http://dx.doi.org/10.4238/gmr16039928

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