Medical Genetics   Research Article

Investigation of the role of apoptosis, necroptosis and DNA damage signaling pathways in multiple sclerosis

Authors: Romina Dastmalchi, Arezou Sayad, Mir Davood Omrani, Soudeh Ghafouri-Fard, Shahram Arsang-Jang, Mehrdokht Mazdeh, Mohammad Taheri*

Multiple sclerosis (MS) as the most common autoimmune disorder in the central nervous system is a major health problem. MS is a complex disease with multiple environmental and genetic factors participating in it. In the present study, we evaluated the expression of 3 genes named BCL2, CASP2 and CASP8 in peripheral blood of 50 MS patients and 50 healthy co.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039937
DOI:
http://dx.doi.org/10.4238/gmr16039937
Medical Genetics   Research Article

Determination of CEBPA mutations in pediatric acute leukemia

Authors: Dilara Fatma Akın Balı, Deniz Aşlar Öner, Emin Kürekçi, Nejat Akar

The CCAAT/enhancer-binding protein-alpha (CEBPA) is lineage-specific transcription factor in the hematopoietic system. Several studies have reported the presence and frequency of CEBPA mutations.In this study, we aimed the clinical features and the prognostic significance associated with CEBPA mutations in 30 pediatric patients with acute leukemia.In addi.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039936
DOI:
http://dx.doi.org/10.4238/gmr16039936
Medical Genetics   Research Article

Association of ACE I/D, AT1R A1166C, CYP11B2 C344T polymorphism with essential hypertension in Asia: A meta-analysis

Authors: Jiang Yuepeng, Zhao Xiaoxuan, Zhao Yang, Sui Yanbo and Liu Li

Aim: To evaluate the association between ACE I/D, AT1R A11166C, CYP11B2 C344T gene polymorphisms and the risk of EH in Asia. Materials and Methods: Related case-control studies were collected, selected and screened; a meta-analysis was conducted to assess the association between polymorphism of target genes and essential hypertension. Results: 41 artic.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039923
DOI:
http://dx.doi.org/10.4238/gmr16039923
Medical Genetics   Review Article

Long non-coding RNA-protein interaction: the preliminary step to track their biological functions

Authors: Amr. R. Ghanam, Wafa Ali, Mohnad Abdalla

RNA is not only an intermediate for the flow of genetic information between DNA and protein. The transcription of the entire genomes generates a myriad non-protein coding RNA in addition to protein coding genes. Among these transcripts, lncRNA which is the least well understood and they cannot be considered as merely transcriptional noises. Here, we revie.. Read More»

Genet. Mol. Res. 17(4):
http://dx.doi.org/gmr16039920
DOI:
http://dx.doi.org/10.4238/gmr16039920
Medical Genetics   Research Article

Anthocyanins-loaded Eudragit® L100 nanoparticles: in vitro cytotoxic and genotoxic analysis

Authors: TB de Queiroz, D Dupeyrón, JCT Carvalho, IOM Gaivão, and EL Maistro

Anthocyanins are flavonoids compounds that have a great therapeutic potential acting as antioxidants, anti-inflammatory and anti-carcinogenic agents. They are consumed through food, pharmaceutical and cosmetics industries as a natural alternative to synthetic dyes. However, anthocyanins are unstable depending on pH, temperatur.. Read More»

Genet. Mol. Res. 17(1):
gmr16039875
DOI:
10.4238/gmr16039875
Medical Genetics   Research Article

ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.16
DOI:
10.4238/2014.December.4.16
Medical Genetics   Research Article

ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.16
DOI:
10.4238/2014.December.4.16
Medical Genetics   Research Article

Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea

Authors: F. Yu1, S. Huang2, F. Zhou2, Q. Luo2, X. Xie3 and C. Zheng2

We examined patients of Han nationality diagnosed with irritable bowel syndrome with diarrhea (IBS-D) in Guangdong, China, to analyze the correlation between DQB1 allele polymorphisms and the genetic susceptibility to IBS-D. A total of 120 IBS-D patients of Han nationality in Guangdong, China, and 60 healthy control volunteers were included. DQB1 allele p.. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.23
DOI:
10.4238/2014.December.4.23
Medical Genetics   Research Article

Comparison of small scale methods for the rapid and efficient extraction of mitochondrial DNA from wheat crop suitable for down stream processes

Authors: M. Ejaz*, Z. Qidi*, Z. Gaisheng, W. Qunzhu, N. Na and Z. Huiyan

We evaluated and compared 2 mitochondrial DNA (mtDNA) extraction methods in terms of DNA quality and success of subsequent polymerase chain reaction (PCR) amplifications from etiolated leaves of wheat crop (Triticum aestivum). mtDNA extraction is difficult because the presence of metabolites interfere with DNA isolation procedures and downstream applicati.. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.27
DOI:
10.4238/2014.December.4.27
Medical Genetics   Research Article

Gender difference in protein expression of vascular wall in mice exposed to chronic intermittent hypoxia: a preliminary study

Authors: Q.Y. Li1*, Y. Feng1*, Y.N. Lin1, M. Li1, Q. Guo1,2, S.Y. Gu1,3, J.L. Liu1, R.F. Zhang1,4 and H.Y. Wan1

Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular diseases such as systemic arterial hypertension, ischemic heart disease, stroke, heart failure, atrial fibrillation, and cardiac sudden death. The pathogenesis of cardiovascular disease in OSA is thought to be induced primarily by chronic intermittent hypoxia (CIH), a specific .. Read More»

Genet. Mol. Res. 13(4):
2014.October.20.25
DOI:
10.4238/2014.October.20.25