Medical Genetics   Research Article

Anthocyanins-loaded Eudragit® L100 nanoparticles: in vitro cytotoxic and genotoxic analysis

Authors: TB de Queiroz, D Dupeyrón, JCT Carvalho, IOM Gaivão, and EL Maistro

Anthocyanins are flavonoids compounds that have a great therapeutic potential acting as antioxidants, anti-inflammatory and anti-carcinogenic agents. They are consumed through food, pharmaceutical and cosmetics industries as a natural alternative to synthetic dyes. However, anthocyanins are unstable depending on pH, temperatur.. Read More»

Genet. Mol. Res. 17(1):
gmr16039875
DOI:
10.4238/gmr16039875
Medical Genetics   Research Article

ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.16
DOI:
10.4238/2014.December.4.16
Medical Genetics   Research Article

ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.16
DOI:
10.4238/2014.December.4.16
Medical Genetics   Research Article

Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea

Authors: F. Yu1, S. Huang2, F. Zhou2, Q. Luo2, X. Xie3 and C. Zheng2

We examined patients of Han nationality diagnosed with irritable bowel syndrome with diarrhea (IBS-D) in Guangdong, China, to analyze the correlation between DQB1 allele polymorphisms and the genetic susceptibility to IBS-D. A total of 120 IBS-D patients of Han nationality in Guangdong, China, and 60 healthy control volunteers were included. DQB1 allele p.. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.23
DOI:
10.4238/2014.December.4.23
Medical Genetics   Research Article

Comparison of small scale methods for the rapid and efficient extraction of mitochondrial DNA from wheat crop suitable for down stream processes

Authors: M. Ejaz*, Z. Qidi*, Z. Gaisheng, W. Qunzhu, N. Na and Z. Huiyan

We evaluated and compared 2 mitochondrial DNA (mtDNA) extraction methods in terms of DNA quality and success of subsequent polymerase chain reaction (PCR) amplifications from etiolated leaves of wheat crop (Triticum aestivum). mtDNA extraction is difficult because the presence of metabolites interfere with DNA isolation procedures and downstream applicati.. Read More»

Genet. Mol. Res. 13(4):
2014.December.4.27
DOI:
10.4238/2014.December.4.27
Medical Genetics   Research Article

Gender difference in protein expression of vascular wall in mice exposed to chronic intermittent hypoxia: a preliminary study

Authors: Q.Y. Li1*, Y. Feng1*, Y.N. Lin1, M. Li1, Q. Guo1,2, S.Y. Gu1,3, J.L. Liu1, R.F. Zhang1,4 and H.Y. Wan1

Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular diseases such as systemic arterial hypertension, ischemic heart disease, stroke, heart failure, atrial fibrillation, and cardiac sudden death. The pathogenesis of cardiovascular disease in OSA is thought to be induced primarily by chronic intermittent hypoxia (CIH), a specific .. Read More»

Genet. Mol. Res. 13(4):
2014.October.20.25
DOI:
10.4238/2014.October.20.25
Medical Genetics   Research Article

A novel nonsense mutation in the sedlin gene (SEDL) causes severe spondyloepiphyseal dysplasia tarda in a five-generation Chinese pedigree

Authors: X.Y. Xia, J. Yu, W.W. Li, N. Li, Q.Y. Wu , X. Zhou, Y.X. Cui and X.J. Li

Spondyloepiphyseal dysplasia tarda (SEDT) is an X-linked recessive osteochondrodysplasia characterized by disproportionately short stature and degenerative joint disease. The objective of this study was to describe a novel nonsense mutation in the sedlin gene (SEDL) causing severe SEDT in a large Chinese pedigree. The clinical.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.April.29.15
DOI:
http://dx.doi.org/10.4238/2014.April.29.15
Medical Genetics   Research Article

Clinical application of carbon nanoparticle lymph node tracer in the VI region lymph node dissection of differentiated thyroid cancer

Authors: S.P. Sun, Y. Zhang, Z.Q. Cui, Q. Chen, W. Zhang, C.X. Zhou, P.P. Xie and B.G. Liu

The application and clinical significance of carbon nanoparticle lymph tracer in the VI region (central region) lymph node dissection of differentiated thyroid cancer was investigated. Eighty patients with differentiated thyroid cancer were equally divided into the carbon nanoparticle-marked group (ipsilateral thyroid injectio.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.April.30.4
DOI:
http://dx.doi.org/10.4238/2014.April.30.4
Medical Genetics   Research Article

Bibliometric network analysis of glaucoma

Authors: L.-Y. Dong, M. Yin and X.-L. Kang

Elevated intraocular pressure is recognized as the principal risk factor for development of optic nerve head (ONH) injury. Lamina cribrosa (LC) cells and astrocytes are two types of cells in the ONH. We attempted to identify more target genes and predict their underlying molecular mechanisms. In this study, we performed meta-analysis of the data from two .. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.9.1
DOI:
http://dx.doi.org/10.4238/2014.May.9.1
Medical Genetics   Research Article

Ginsenoside Rh2 promotes nonamyloidgenic cleavage of amyloid precursor protein via a cholesterol-dependent pathway

Authors: J. Qiu, W. Li, S.H. Feng, M. Wang and Z.Y. He

Ginsenoside Rh2 (Rh2) is a ginseng derivative used in Chinese traditional medicine. We investigated whether Rh2 can help prevent Alzheimer’s disease symptoms and examined underlying mechanisms. We injected Rh2 into tg2576 Alzheimer’s disease model mice and looked for behavioral improvement and senile plaque reducti.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.9.2
DOI:
http://dx.doi.org/10.4238/2014.May.9.2