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Medical Genetics   Research Article

Genetic variants of the endothelial NO synthase gene (eNOS) may confer increased risk of sporadic congenital heart disease

Authors: K. Zhou, Y. Wang, W. Peng, J. Sun, Y.M. Qing and X.M. Mo

The endothelial NO synthase (eNOS) enzyme is expressed during the early stages of cardiogenesis and plays an important role in normal heart development. Genetic variations of eNOS G894T have been shown to influence individual susceptibility to some phenotypes of congenital heart disease (CHD) in different populations. We condu.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.4
DOI:
http://dx.doi.org/10.4238/2014.May.16.4
Medical Genetics   Research Article

Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma

Authors: J.S. Wu, Y.P. Chen, L.C. Wang, Y.J. Yang, C.W. Deng, B.X. Hou, Z.L. He and J.X. Chen

We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total of 218 cases with HCC and 277 healthy controls were included in the study. Genotyping of the XRCC1 (Arg194Trp and Arg399Gln) and XPD.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.5
DOI:
http://dx.doi.org/10.4238/2014.May.16.5
Medical Genetics   Research Article

High-sensitivity cardiac troponin T is a predictor of recurrent acute coronary syndrome in patients with acute myocardial infarction

Authors: S.-C. Sheng, X.-M. Lu, Y. Kang, Y.-P. Du and G.-X. Wang

High-sensitivity cardiac troponin T is a useful tool for diagnosing myocardial ischemia. However, its role in the prognosis of patients with acute myocardial infarction has not been studied. Here, the prognostic value of high-sensitivity cardiac troponin T for patients with acute myocardial infarction was investigated. The con.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.6
DOI:
http://dx.doi.org/10.4238/2014.May.16.6
Medical Genetics   Research Article

Association of -238G/A and -863C/A polymorphisms in the TNF-α gene with chronic obstructive pulmonary disease based on a meta-analysis

Authors: K. Cui, X.Y. Ge and H.L. Ma

Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease; increasing evidence indicates that the TNF-α polymorphism is associated with progression of this disease. Few studies have focused upon association between TNF-α -238G/A or -863C/A polymorphism and COPD risk. Reported associations have been controversial b.. Read More»

Genet. Mol. Res. 12(4):
2013.October.24.10
DOI:
10.4238/2013.October.24.10
Medical Genetics   Research Article

Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk

Authors: W.K. Zhou, L.Y. Huang, L. Hui, Z.W. Wang, B.Z. Jin, X.L. Zhao, X.Z. Zhang, J.X. Wang, J.C. Wang and R.Z. Wang

We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and .. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.7
DOI:
http://dx.doi.org/10.4238/2014.May.16.7
Medical Genetics   Research Article

Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts

Authors: Z.-Y. Wu, L. Lu, J. Liang, X.-R. Guo, P.H. Zhang and S.-J. Luo

The purpose of this study was to identify microRNAs (miRNAs) involved in keloid formation and determine their influence on the proliferation of keloid fibroblasts (KFs). Eight specimens each of resected keloid tissue and normal skin tissue were collected. miRNAs that are differentially expressed in keloid tissue and normal ski.. Read More»

Genet. Mol. Res. 13(2):
2014.April.14.2
DOI:
10.4238/2014.April.14.2
Medical Genetics   Research Article

Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene

Authors: J.-S. Huang, M.-D. Zhao, J.-M. Shi, J.-H. Zhang, B. Li, W. Fan, Y.-L. Zhou

ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophil.. Read More»

Genet. Mol. Res. 12(4):
2013.November.22.11
DOI:
10.4238/2013.November.22.11
Medical Genetics   Research Article

Effect of RNAi-mediated silencing of Livin gene on biological properties of colon cancer cell line LoVo

Authors: A.M. Zou, H.F. Wang, W.F. Zhu, F.X. Wang and J.J. Shen

This study aimed to investigate the effect of RNAi-mediated silencing of the Livin gene on biological properties of the colon cancer cell line LoVo. Interference vectors pSilencer4.1-Ll and pSilencer4.1-L2 targeting the Livin gene were constructed and transfected into LoVo cells. The expression of the Livin gene was determined.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.8
DOI:
http://dx.doi.org/10.4238/2014.May.16.8
Medical Genetics   Research Article

A multi-farm assessment of Greek black pig genetic diversity using microsatellite molecular markers

Authors: S. Michailidou, A. Kalivas, I. Ganopoulos, E. Stea, G. Michailidis, A. Tsaftaris and A. Argiriou

Local breeds are important for the maintenance of genetic diversity and future food security. Nowadays, the worldwide distribution of pigs is dominated by a few breeds, tending towards a severe loss of pig biodiversity. Thus, it is critical to maintain distinct populations of pig breeds. The Greek black pig, a breed raised loc.. Read More»

Genet. Mol. Res. 13(2):
2014.April.14.4
DOI:
10.4238/2014.April.14.4
Medical Genetics   Research Article

In vivo mechanism study of NGAL in rat renal ischemia-reperfusion injury

Authors: X.J. Zang1, S.X. An2, Z. Feng1, Y.P. Xia1, Y. Song and Q. Yu

This study aimed to determine the protective effect and mechanism of neutrophil gelatinase-associated lipocalin (NGAL) in rat kidney on ischemia/reperfusion injury (I/R). The rat I/R model was set up by cutting one kidney and clamping the contralateral renal pedicle for 45 min. Male SD rats were randomly divided into sham-oper.. Read More»

Genet. Mol. Res. 13(4):

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