Medical Genetics
A tiered barcode authentication tool to differentiate medicinal Cassia species in India
Authors: N. Purushothaman, S.G. Newmaster, S. Ragupathy, N. Stalin, D. Suresh, D.R. Arunraj, G. Gnanasekaran, S.L. Vassou, D. Narasimhan and M. Parani
DNA barcoding is a desirable tool for medicinal product authentication. DNA barcoding is a method for species identification using short DNA sequences that are conserved within species, but variable between species. Unlike animals, there is no single universal DNA barcode locus for plants. Coding markers, matK and rbcL, and no.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.16.4
- DOI:
- 10.4238/2014.April.16.4
Polymorphisms in the XRCC1 gene are associated with treatment response to platinum chemotherapy in advanced non-small cell lung cancer patients based on meta-analysis
Authors: L. Li, C. Wan and F.Q. Wen
X-ray repair cross complementing group 1(XRCC1) polymorphisms have been implicated in interindividual variability of efficacy of platinum chemotherapy for treating non-small cell lung cancer (NSCLC); however, results of different studies have been inconsistent. We conducted a meta-analysis to investigate the association betwee.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.1
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.1
Homocysteine induces blood vessel global hypomethylation mediated by LOX-1
Authors: X.L. Yang, J. Tian, Y. Liang, C.J. Ma, A.N. Yang, J. Wang, S.C. Ma, Y. Cheng, X. Hua and Y.D. Jiang
Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change i.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.2
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.2
Genetic variants of the endothelial NO synthase gene (eNOS) may confer increased risk of sporadic congenital heart disease
Authors: K. Zhou, Y. Wang, W. Peng, J. Sun, Y.M. Qing and X.M. Mo
The endothelial NO synthase (eNOS) enzyme is expressed during the early stages of cardiogenesis and plays an important role in normal heart development. Genetic variations of eNOS G894T have been shown to influence individual susceptibility to some phenotypes of congenital heart disease (CHD) in different populations. We condu.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.4
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.4
Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma
Authors: J.S. Wu, Y.P. Chen, L.C. Wang, Y.J. Yang, C.W. Deng, B.X. Hou, Z.L. He and J.X. Chen
We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total of 218 cases with HCC and 277 healthy controls were included in the study. Genotyping of the XRCC1 (Arg194Trp and Arg399Gln) and XPD.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.5
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.5
High-sensitivity cardiac troponin T is a predictor of recurrent acute coronary syndrome in patients with acute myocardial infarction
Authors: S.-C. Sheng, X.-M. Lu, Y. Kang, Y.-P. Du and G.-X. Wang
High-sensitivity cardiac troponin T is a useful tool for diagnosing myocardial ischemia. However, its role in the prognosis of patients with acute myocardial infarction has not been studied. Here, the prognostic value of high-sensitivity cardiac troponin T for patients with acute myocardial infarction was investigated. The con.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.6
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.6
Association of -238G/A and -863C/A polymorphisms in the TNF-�± gene with chronic obstructive pulmonary disease based on a meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease; increasing evidence indicates that the TNF-α polymorphism is associated with progression of this disease. Few studies have focused upon association between TNF-α -238G/A or -863C/A polymorphism and COPD risk. Reported associations have been controversial b.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.10
- DOI:
- 10.4238/2013.October.24.10
Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk
Authors: W.K. Zhou, L.Y. Huang, L. Hui, Z.W. Wang, B.Z. Jin, X.L. Zhao, X.Z. Zhang, J.X. Wang, J.C. Wang and R.Z. Wang
We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.7
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.7
Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts
Authors: Z.-Y. Wu, L. Lu, J. Liang, X.-R. Guo, P.H. Zhang and S.-J. Luo
The purpose of this study was to identify microRNAs (miRNAs) involved in keloid formation and determine their influence on the proliferation of keloid fibroblasts (KFs). Eight specimens each of resected keloid tissue and normal skin tissue were collected. miRNAs that are differentially expressed in keloid tissue and normal ski.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.14.2
- DOI:
- 10.4238/2014.April.14.2
Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene
Authors: J.-S. Huang, M.-D. Zhao, J.-M. Shi, J.-H. Zhang, B. Li, W. Fan, Y.-L. Zhou
ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophil.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.11
- DOI:
- 10.4238/2013.November.22.11