Medical Genetics
CpG ODN 1826 enhances radiosensitivity of the human lung cancer cell line A549 in a rat model
Authors: W. Yan, T.-Y. Sun, C.-M. Yang, M. Jia, J. Li, H.-L. Tang and Y.-F. Zhou
This study investigated the effects of CpG ODN1826 plus radiotherapy (RT) on tumor growth and angiogenesis of subcutaneous tumor in a rat model. Four treatment groups were tested in which rats were injected with 100 μL CpG ODN1826 (1 μg/μL) or 100 μL vehicle, with and without exposure to 8 Gy after 2 h. At 7 days after inoculation of lung canc.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.13
- DOI:
- 10.4238/2015.August.19.13
Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population
Authors: J.Q. Liang, Y.G. Xi, C.Y. An and X.L. Su
Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotypin.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.9
- DOI:
- 10.4238/2015.August.21.9
Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling
Authors: H.G. Zhang, R.X. Wang, L.L. Li, W.T. Sun, H.Y. Zhang and R.Z. Liu
Balanced chromosomal translocations in men can cause failure of spermatogenesis owing to meiotic impairment. Male carriers may exhibit normozoospermia, although clinical manifestations can include oligozoospermia or azoospermia, oligozoospermia or normozoospermia. Here, we reported the characteristics of balanced reciprocal translocations in men from nort.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.28
- DOI:
- 10.4238/2015.December.28.28
Expression patterns of melatonin receptors in chicken ovarian follicles affected by monochromatic light
Authors: D.Y. Li, N. Wu, J.B. Tu, Y.D. Hu, M.Y. Yang, H.D. Yin, B.L. Chen, H.L. Xu, Y.F. Yao and Q. Zhu
Artificial illumination is an important exogenous factor in the control of many physiological and behavioral processes as well as an important environmental factor in the management of laying hens. Melatonin receptors are members of the G protein-coupled receptor family. The hormone melatonin is secreted primarily by the pineal gland, with highest levels .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.14
- DOI:
- 10.4238/2015.August.21.14
Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population
Authors: Y. Yang, J.R. Xu, Y.J. Wang and X.M. Li
Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui popula.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.13
- DOI:
- 10.4238/2015.August.21.13
Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo
Authors: Y.B. Deng, H.J. Qin, Y.H. Luo, Z.R. Liang and J.J. Zou
We investigated the effects of hepatitis B virus (HBV) S/C double gene loci antisense locked nucleic acid on replication and expression of HBV in hepatitis transgenic mice. HBV mice (N = 30) were randomly divided into five groups of six mice: 5% glucose solution control, empty liposome control, single-target S, single-target C, and dual-target SC groups. .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.16
- DOI:
- 10.4238/2015.August.21.16
Effect of DNase treatment on RNA extraction from preimplantation murine embryos
Authors: J. Norhazlin, M.N.K. Nor-Ashikin, B.P. Hoh, S.H. Sheikh Abdul Kadir, S. Norita, M. Mohd-Fazirul, W.J. Wan-Hafizah, D. Razif, M.H. Rajikin and B. Abdullah
The quality of RNA is crucial when performing microarray experiments. This is particularly important when dealing with preimplantation embryos, from which a minimum yield of RNA of good quality can be produced. We report the optimization of several RNA extraction methods applied to preimplantation embryos at different stages of development. The quality of.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.1
- DOI:
- 10.4238/2015.August.28.1
Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer
Authors: J.Y. Liu, Q.M. Liu and L.R. Li
We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.19
- DOI:
- 10.4238/2015.August.28.19
EDA mutation as a cause of hypohidrotic ectodermal dysplasia: a case report and review of the literature
Authors: S.X. Huang, J.L. Liang, W.G. Sui, H. Lin, W. Xue, J.J. Chen, Y. Zhang, W.W. Gong, Y. Dai and M.L. Ou
Ectodermal dysplasia (ED) represents a collection of rare disorders that result from a failure of development of the tissues derived from the embryonic ectoderm. ED is often associated with hair, teeth, and skin abnormalities, which are serious conditions affecting the quality of life of the patient. To date, a large number of genes have been found to be .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.21
- DOI:
- 10.4238/2015.August.28.21
Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance
Authors: X. Yu, Y. Li, S.W. Chen, Y. Shi and F. Xu
In this study, we examined the expression of glypican-3 (GPC3) in the 2 most common histological types of lung cancer, squamous cell carcinoma and adenocarcinoma, and explored the relationship between GPC3 expression and the prognosis of these 2 types of lung cancers. Lung cancer tissues and paracancerous tissues were collected from a total of 60 patients.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.2
- DOI:
- 10.4238/2015.August.28.2