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Medical Genetics   Research Article

SLC2A9 and ZNF518B polymorphisms correlate with gout-related metabolic indices in Chinese Tibetan populations

Authors: X.Y. Zhang, T.T. Geng, L.J. Liu, D.Y. Yuan, T. Feng, L.L. Kang, T.B. Jin and C. Chen

Current evidence suggests that heredity and metabolic syndrome contribute to gout progression. SLC2A9 and ZNF518B may play a role in gout progression in different populations, but no studies have focused on the Tibetan Chinese population. In this study, wedetermined whether variations in these 2 genes were correlated with gout-related indices in Chinese-T.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.26
DOI:
10.4238/2015.August.19.26
Medical Genetics   Research Article

Polymorphic microsatellite markers in the traditional Chinese medicinal plant Paris polyphylla var. yunnanensis

Authors: Y. Song, M.F. Li, J. Xu, Z. Zha and N.Z. Chen

Paris polyphylla var. yunnanensis is a traditional Chinese medicinal plant and is listed as vulnerable by the IUCN. This medicinal herb is well known for its analgesic and anti-inflammatory properties, most notably as an ingredient of the hemostatic compound “Yunnan Baiyao”. However, over-exploitation of the plant for economic purposes is push.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.29
DOI:
10.4238/2015.August.19.29
Medical Genetics   Research Article

Proline accumulation is a general response to abiotic stress in the date palm tree (Phoenix dactylifera L.)

Authors: M.W. Yaish

Plants exposed to certain abiotic stress conditions tend to produce the amino acid proline, which acts as an active osmolyte, a metal chelator, an antioxidant, and a signaling molecule. There is increasing evidence that proline accumulates in plants due to a wide range of abiotic stress, in particular high soil salinity and drought. Therefore, proline con.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.30
DOI:
10.4238/2015.August.19.30
Medical Genetics   Research Article

Potential of berberine to enhance antimicrobial activity of commonly used antibiotics for dairy cow mastitis caused by multiple drug-resistant Staphylococcus epidermidis infection

Authors: X. Zhou, C. Yang, Y. Li, X. Liu and Y. Wang

Berberine is a plant alkaloid with antimicrobial activity against a variety of microorganisms. In this study, the antimicrobial properties of berberine against multi-drug resistant field isolates of Staphylococcus epidermidis were investigated using berberine alone or in combination with a commonly used antibiotics in veterinary clinics, including penicil.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.1
DOI:
10.4238/2015.August.19.1
Medical Genetics   Research Article

Genetic diversity analysis of sweet kernel apricot in China based on SSR and ISSR markers

Authors: M.P. Liu, H.Y. Du, G.P. Zhu, D.L. Fu and W.Y. Tana

Simple sequence repeat (SSR) and inter-simple sequence repeat (ISSR) markers were used to evaluate genetic diversity among 22 sweet kernel apricot accessions and 12 cultivars in China to provide information on how to improve the utilization of kernel apricot germplasms. The results showed that 10 pairs of SSR primers screened from 40 primer pairs amplifie.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.4
DOI:
10.4238/2015.August.19.4
Medical Genetics   Research Article

Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae)

Authors: P.L. de Freitas, A.C.S. Dias, V.R. Moreira, S.G. Monteiro and S.R.F. Pereira

The mutagenic and antimutagenic activities of triterpene betulinic acid {3b-3-hydroxy-lup-20(29)-en-28-oic} isolated from the roots of Scoparia dulcis (Scrophulariaceae) were analyzed using the somatic mutation and recombination test (SMART) in the wings of Drosophila melanogaster. The mutagenic potential of betulinic acid was evaluated at 3 different con.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.7
DOI:
10.4238/2015.August.19.7
Medical Genetics   Research Article

Identification of conservation units of the hynobiid salamander Pachyhynobius shangchengensis

Authors: L.-N. Su, Y.-Y. Zhao, X.-M. Wu, H.-F. Zhang and X.-C. Li

The evolutionary significant units (ESUs) of the salamander Pachyhynobius shangchengensis (Hynobiidae) in the Dabieshan mountains, southeastern China, were identified based on mitochondrial DNA data. We used methods for detecting cryptic species, such as the minimum spanning tree, the automatic barcode gap discovery, and the generalized mixed Yule-coalesc.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.10
DOI:
10.4238/2015.August.19.10
Medical Genetics   Research Article

CpG ODN 1826 enhances radiosensitivity of the human lung cancer cell line A549 in a rat model

Authors: W. Yan, T.-Y. Sun, C.-M. Yang, M. Jia, J. Li, H.-L. Tang and Y.-F. Zhou

This study investigated the effects of CpG ODN1826 plus radiotherapy (RT) on tumor growth and angiogenesis of subcutaneous tumor in a rat model. Four treatment groups were tested in which rats were injected with 100 μL CpG ODN1826 (1 μg/μL) or 100 μL vehicle, with and without exposure to 8 Gy after 2 h. At 7 days after inoculation of lung canc.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.13
DOI:
10.4238/2015.August.19.13
Medical Genetics   Research Article

Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population

Authors: J.Q. Liang, Y.G. Xi, C.Y. An and X.L. Su

Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotypin.. Read More»

Genet. Mol. Res. 14(3):
2015.August.21.9
DOI:
10.4238/2015.August.21.9
Medical Genetics   Research Article

Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling

Authors: H.G. Zhang, R.X. Wang, L.L. Li, W.T. Sun, H.Y. Zhang and R.Z. Liu

Balanced chromosomal translocations in men can cause failure of spermatogenesis owing to meiotic impairment. Male carriers may exhibit normozoospermia, although clinical manifestations can include oligozoospermia or azoospermia, oligozoospermia or normozoospermia. Here, we reported the characteristics of balanced reciprocal translocations in men from nort.. Read More»

Genet. Mol. Res. 14(4):
2015.December.28.28
DOI:
10.4238/2015.December.28.28

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