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Medical Genetics   Research Article

Expression patterns of melatonin receptors in chicken ovarian follicles affected by monochromatic light

Authors: D.Y. Li, N. Wu, J.B. Tu, Y.D. Hu, M.Y. Yang, H.D. Yin, B.L. Chen, H.L. Xu, Y.F. Yao and Q. Zhu

Artificial illumination is an important exogenous factor in the control of many physiological and behavioral processes as well as an important environmental factor in the management of laying hens. Melatonin receptors are members of the G protein-coupled receptor family. The hormone melatonin is secreted primarily by the pineal gland, with highest levels .. Read More»

Genet. Mol. Res. 14(3):
2015.August.21.14
DOI:
10.4238/2015.August.21.14
Medical Genetics   Research Article

Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population

Authors: Y. Yang, J.R. Xu, Y.J. Wang and X.M. Li

Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui popula.. Read More»

Genet. Mol. Res. 14(3):
2015.August.21.13
DOI:
10.4238/2015.August.21.13
Medical Genetics   Research Article

Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo

Authors: Y.B. Deng, H.J. Qin, Y.H. Luo, Z.R. Liang and J.J. Zou

We investigated the effects of hepatitis B virus (HBV) S/C double gene loci antisense locked nucleic acid on replication and expression of HBV in hepatitis transgenic mice. HBV mice (N = 30) were randomly divided into five groups of six mice: 5% glucose solution control, empty liposome control, single-target S, single-target C, and dual-target SC groups. .. Read More»

Genet. Mol. Res. 14(3):
2015.August.21.16
DOI:
10.4238/2015.August.21.16
Medical Genetics   Research Article

Effect of DNase treatment on RNA extraction from preimplantation murine embryos

Authors: J. Norhazlin, M.N.K. Nor-Ashikin, B.P. Hoh, S.H. Sheikh Abdul Kadir, S. Norita, M. Mohd-Fazirul, W.J. Wan-Hafizah, D. Razif, M.H. Rajikin and B. Abdullah

The quality of RNA is crucial when performing microarray experiments. This is particularly important when dealing with preimplantation embryos, from which a minimum yield of RNA of good quality can be produced. We report the optimization of several RNA extraction methods applied to preimplantation embryos at different stages of development. The quality of.. Read More»

Genet. Mol. Res. 14(3):
2015.August.28.1
DOI:
10.4238/2015.August.28.1
Medical Genetics   Research Article

Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer

Authors: J.Y. Liu, Q.M. Liu and L.R. Li

We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymo.. Read More»

Genet. Mol. Res. 14(3):
2015.August.28.19
DOI:
10.4238/2015.August.28.19
Medical Genetics   Research Article

EDA mutation as a cause of hypohidrotic ectodermal dysplasia: a case report and review of the literature

Authors: S.X. Huang, J.L. Liang, W.G. Sui, H. Lin, W. Xue, J.J. Chen, Y. Zhang, W.W. Gong, Y. Dai and M.L. Ou

Ectodermal dysplasia (ED) represents a collection of rare disorders that result from a failure of development of the tissues derived from the embryonic ectoderm. ED is often associated with hair, teeth, and skin abnormalities, which are serious conditions affecting the quality of life of the patient. To date, a large number of genes have been found to be .. Read More»

Genet. Mol. Res. 14(3):
2015.August.28.21
DOI:
10.4238/2015.August.28.21
Medical Genetics   Research Article

Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance

Authors: X. Yu, Y. Li, S.W. Chen, Y. Shi and F. Xu

In this study, we examined the expression of glypican-3 (GPC3) in the 2 most common histological types of lung cancer, squamous cell carcinoma and adenocarcinoma, and explored the relationship between GPC3 expression and the prognosis of these 2 types of lung cancers. Lung cancer tissues and paracancerous tissues were collected from a total of 60 patients.. Read More»

Genet. Mol. Res. 14(3):
2015.August.28.2
DOI:
10.4238/2015.August.28.2
Medical Genetics   Research Article

PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis

Authors: Y.H. Lee and G.G. Song

We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferatoractivated receptor gamma (PPARg) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a metaanalysis of the associations between the PPARg Pro12Ala and His447His polymorphisms and AD in subjects. The meta-anal.. Read More»

Genet. Mol. Res. 14(2):
2015.June.29.18
DOI:
10.4238/2015.June.29.18
Medical Genetics   Research Article

Genotoxic evaluation of the organophosphorous pesticide temephos

Authors: Cláudia Alessandra Fortes Aiub, Elisângela Cristina Alves Coelho, Eduardo Sodré, Luis Felipe Ribeiro Pinto and Israel Felzenszwalb

The chemical compound temephos (0,0,0',0'-tetrametyl-0,0'-thiodi-p-phenylene phosphorothioate) is an organophosphorous pesticide that has been used in Brazil since 1967 in control campaigns against the mosquito Aedes aegypti, the vector of dengue and yellow fever. We used single cell gel electrophoresis (SCGE), SOS/umu and Ame.. Read More»

Genet. Mol. Res. 1(2):

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