Medical Genetics
Relationship between melanoma-associated antigen 1 (MAGE-A1) gene polymorphisms and colorectal cancer development
Authors: Mikhlid Almutairi and Abdelhabib Semlali
In the Saudi population, colorectal cancer (CRC) is the first and third most common malignancy among males and females, respectively. The CRC risk is associated with the expression of certain genes, which can be used for prognoses and for finding screening-related biomarkers. One such gene is melanoma-associated antigen 1 (MAGE-A1); however, little is kno.. Read More»
- Genet. Mol. Res. 18(4):
Investigation of the role of apoptosis, necroptosis and DNA damage signaling pathways in multiple sclerosis
Authors: Romina Dastmalchi, Arezou Sayad, Mir Davood Omrani, Soudeh Ghafouri-Fard, Shahram Arsang-Jang, Mehrdokht Mazdeh, Mohammad Taheri*
Multiple sclerosis (MS) as the most common autoimmune disorder in the central nervous system is a major health problem. MS is a complex disease with multiple environmental and genetic factors participating in it. In the present study, we evaluated the expression of 3 genes named BCL2, CASP2 and CASP8 in peripheral blood of 50 MS patients and 50 healthy co.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039937
- DOI:
- http://dx.doi.org/10.4238/gmr16039937
Long non-coding RNA-protein interaction: the preliminary step to track their biological functions
Authors: Amr. R. Ghanam, Wafa Ali, Mohnad Abdalla
RNA is not only an intermediate for the flow of genetic information between DNA and protein. The transcription of the entire genomes generates a myriad non-protein coding RNA in addition to protein coding genes. Among these transcripts, lncRNA which is the least well understood and they cannot be considered as merely transcriptional noises. Here, we revie.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039920
- DOI:
- http://dx.doi.org/10.4238/gmr16039920
Anthocyanins-loaded Eudragit�® L100 nanoparticles: in vitro cytotoxic and genotoxic analysis
Authors: TB de Queiroz, D Dupeyr�³n, JCT Carvalho, IOM Gaiv�£o, and EL Maistro
Anthocyanins are flavonoids compounds that have a great therapeutic potential acting as antioxidants, anti-inflammatory and anti-carcinogenic agents. They are consumed through food, pharmaceutical and cosmetics industries as a natural alternative to synthetic dyes. However, anthocyanins are unstable depending on pH, temperatur.. Read More»
- Genet. Mol. Res. 17(1):
- gmr16039875
- DOI:
- 10.4238/gmr16039875
ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy
Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2
We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.16
- DOI:
- 10.4238/2014.December.4.16
ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy
Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2
We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.16
- DOI:
- 10.4238/2014.December.4.16
Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea
Authors: F. Yu1, S. Huang2, F. Zhou2, Q. Luo2, X. Xie3 and C. Zheng2
We examined patients of Han nationality diagnosed with irritable bowel syndrome with diarrhea (IBS-D) in Guangdong, China, to analyze the correlation between DQB1 allele polymorphisms and the genetic susceptibility to IBS-D. A total of 120 IBS-D patients of Han nationality in Guangdong, China, and 60 healthy control volunteers were included. DQB1 allele p.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.23
- DOI:
- 10.4238/2014.December.4.23
Comparison of small scale methods for the rapid and efficient extraction of mitochondrial DNA from wheat crop suitable for down stream processes
Authors: M. Ejaz*, Z. Qidi*, Z. Gaisheng, W. Qunzhu, N. Na and Z. Huiyan
We evaluated and compared 2 mitochondrial DNA (mtDNA) extraction methods in terms of DNA quality and success of subsequent polymerase chain reaction (PCR) amplifications from etiolated leaves of wheat crop (Triticum aestivum). mtDNA extraction is difficult because the presence of metabolites interfere with DNA isolation procedures and downstream applicati.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.27
- DOI:
- 10.4238/2014.December.4.27
Gender difference in protein expression of vascular wall in mice exposed to chronic intermittent hypoxia: a preliminary study
Authors: Q.Y. Li1*, Y. Feng1*, Y.N. Lin1, M. Li1, Q. Guo1,2, S.Y. Gu1,3, J.L. Liu1, R.F. Zhang1,4 and H.Y. Wan1
Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular diseases such as systemic arterial hypertension, ischemic heart disease, stroke, heart failure, atrial fibrillation, and cardiac sudden death. The pathogenesis of cardiovascular disease in OSA is thought to be induced primarily by chronic intermittent hypoxia (CIH), a specific .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.25
- DOI:
- 10.4238/2014.October.20.25
A novel nonsense mutation in the sedlin gene (SEDL) causes severe spondyloepiphyseal dysplasia tarda in a five-generation Chinese pedigree
Authors: X.Y. Xia, J. Yu, W.W. Li, N. Li, Q.Y. Wu , X. Zhou, Y.X. Cui and X.J. Li
Spondyloepiphyseal dysplasia tarda (SEDT) is an X-linked recessive osteochondrodysplasia characterized by disproportionately short stature and degenerative joint disease. The objective of this study was to describe a novel nonsense mutation in the sedlin gene (SEDL) causing severe SEDT in a large Chinese pedigree. The clinical.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.April.29.15
- DOI:
- http://dx.doi.org/10.4238/2014.April.29.15