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Medical Genetics   Research Article

Endophytic bacteria from banana cultivars and their antifungal activity

Authors: A. Souza1, J.C. Cruz2, N.R. Sousa2, A.R.L. Procópio1 and G.F. Silva2

Endophytic microorganisms consist of fungi, bacteria, and actinomycetes that play important roles in the process of plant adaptation to the environment. Currently, the natural associations between microorganisms and plant species are being explored for a large number of biotechnological applications. In this study, 122 endophytic bacteria were isolated fr.. Read More»

Genet. Mol. Res. 13(4):
Medical Genetics   Research Article

Clinical value of surfactant protein-A in serum and sputum for pulmonary tuberculosis diagnosis

Authors: H. Hu, G.L. Teng, L.Z. Gai, Y. Yang and C.J. Zhu

The aim of this study was to explore the diagnostic and differential diagnosis value of surfactant protein-A (SP-A) in the serum and sputum for pulmonary tuberculosis. A total of 101 patients with pulmonary tuberculosis, 85 healthy volunteers, and 30 chronic obstructive pulmonary disease (COPD) patients were divided into pulmonary tuberculosis group, heal.. Read More»

Genet. Mol. Res. 12(4):
2013.October.24.2
DOI:
10.4238/2013.October.24.2
Medical Genetics   Research Article

Long-term survival of non-small-cell lung cancer patients with EGFR inhibitor treatment

Authors: M.X. Zhang1,2, W. Tan1, R.X. Zhang3, Y.L. Tian1, H.M. Gao1,2, Z. Gao1, N. Zhang1, J.Q. Zhao1, Y.F. Jia1,2 and Y.S. Wang1,2

The epidermal growth factor receptor (EGFR) inhibitors gefitinib and erlotinib are effective in the treatment of advanced non-small-cell lung cancer (NSCLC), but the median survival of patients is short. Here, we describe 2 patients with NSCLC receiving conventional chemotherapy and alternative treatment with gefitinib or erlotinib as second-line therapy... Read More»

Genet. Mol. Res. 13(4):
Medical Genetics   Research Article

Preset ureter catheter in laparoscopic radical hysterectomy of cervical cancer

Authors: L. Han, R. Cao, J.Y. Jiang, Y. Xi, X.C. Li and G.H. Yu

The aim of this study was to evaluate the clinical efficacy of a temporary ureteral catheter in preventing iatrogenic ureteral damage in cervical cancer patients undergoing laparoscopic radical hysterectomy. All cases had confirmed diagnoses of cervical cancer preoperatively between December 2008 and December 2012 in our hospi.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.9.6
DOI:
http://dx.doi.org/10.4238/2014.May.9.6
Medical Genetics   Research Article

De novo DNA methylation of the paternal genome in 2-cell mouse embryos

Authors: X.S. Ma1, X.G. Wang1,2, L. Qin1, C.L. Song1, F. Lin1, J.M. Song1, C.C. Zhu1 and H.L. Liu

The developmental dynamics of DNA methylation events have been well studied. Active demethylation of the paternal genome occurs in the zygote, passive demethylation occurs during cleavage stages, and de novo methylation occurs by the blastocyst stage. It is believed that the paternal genome has lower levels of methylation during early development than the.. Read More»

Genet. Mol. Res. 13(4):
Medical Genetics   Research Article

DNA elimination in embryogenic development of Pennisetum glaucum x Pennisetum purpureum (Poaceae) hybrids

Authors: J.D. Nunes1, A.L.S. Azevedo1, A.V. Pereira1, C.M.P. Paula2, J.M.S. Campos3, F.J.S. Lédo1 and V.B. Santos4

Interspecific hybridization between Napier grass (Pennisetum purpureum), which is widely grown in Brazil for cattle forage, and pearl millet (Pennisetum glaucum) has been used as a breeding strategy for the development of improved cultivars. However, the hybrid between these two species is sterile due to its triploid condition (2n = 3x = 21 chromosomes), .. Read More»

Genet. Mol. Res. 12(4):
2013.October.22.1
DOI:
10.4238/2013.October.22.1
Medical Genetics   Research Article

Interleukin-7 receptor gene polymorphism at +1237 locus and its effect on susceptibility to opportunistic infections among HIV and AIDS patients in Limpopo Province, South Africa

Authors: A. Samie, G.T. Moloro and T.C. Nangammbi

Over the past decade, an increasing number of studies have demonstrated correlations between host genetics and susceptibility to diseases. However, few studies have investigated the effects of host genetics on the occurrence of opportunistic infections among human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) patients. In the .. Read More»

Genet. Mol. Res. 13(4):
Medical Genetics   Research Article

A tiered barcode authentication tool to differentiate medicinal Cassia species in India

Authors: N. Purushothaman, S.G. Newmaster, S. Ragupathy, N. Stalin, D. Suresh, D.R. Arunraj, G. Gnanasekaran, S.L. Vassou, D. Narasimhan and M. Parani

DNA barcoding is a desirable tool for medicinal product authentication. DNA barcoding is a method for species identification using short DNA sequences that are conserved within species, but variable between species. Unlike animals, there is no single universal DNA barcode locus for plants. Coding markers, matK and rbcL, and no.. Read More»

Genet. Mol. Res. 13(2):
2014.April.16.4
DOI:
10.4238/2014.April.16.4
Medical Genetics   Research Article

Polymorphisms in the XRCC1 gene are associated with treatment response to platinum chemotherapy in advanced non-small cell lung cancer patients based on meta-analysis

Authors: L. Li, C. Wan and F.Q. Wen

X-ray repair cross complementing group 1(XRCC1) polymorphisms have been implicated in interindividual variability of efficacy of platinum chemotherapy for treating non-small cell lung cancer (NSCLC); however, results of different studies have been inconsistent. We conducted a meta-analysis to investigate the association betwee.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.1
DOI:
http://dx.doi.org/10.4238/2014.May.16.1
Medical Genetics   Research Article

Homocysteine induces blood vessel global hypomethylation mediated by LOX-1

Authors: X.L. Yang, J. Tian, Y. Liang, C.J. Ma, A.N. Yang, J. Wang, S.C. Ma, Y. Cheng, X. Hua and Y.D. Jiang

Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change i.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.2
DOI:
http://dx.doi.org/10.4238/2014.May.16.2

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