Gastric Cancer
Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer
Authors: J. Lin, R.M. Zeng, R.N. Li and W.H. Cao
Epidemiological studies have indicated that folate metabolism is correlated with increased risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gast.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.10
- DOI:
- 10.4238/2014.March.24.10
Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis
Authors: Y.P. Gu, Q.Y. Yuan, H. Zhang, C.J. Wang and F. Zhou
Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.4
- DOI:
- 10.4238/2015.July.28.4
Impact of enteral nutrition on postoperative immune function and nutritional status
Authors: F. Wang, M.X. Hou, X.L. Wu, L.D. Bao and P.D. Dong
We studied the effects of enteral nutrition (EN) support initiated 1 week before surgery on postoperative nutritional status, immune function, and inflammatory response in gastric cancer patients. A total of 200 gastric cancer patients were randomly divided into two groups: EN starting 1 week before surgery (study group) and EN starting early after surger.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.4
- DOI:
- 10.4238/2015.June.8.4
Common polymorphisms of the microRNA genes (miR-146a and miR-196a-2) and gastric cancer risk: an updated meta-analysis
Authors: Z.F. Chen, L.L. Ma and H.B. Xue
The associations between two common polymorphisms in microRNA genes (miR-146a, dbSNP: rs2910164; miR-196a-2, dbSNP: rs11614913) and gastric cancer risk have frequently been examined; however, the results have often been controversial. This meta-analysis was performed to clarify the association between the two polymorphisms and gastric cancer risk. The lit.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.7
- DOI:
- 10.4238/2015.July.31.7
Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells
Authors: Y.H. Li, M. Chen, M. Zhang, X.Q. Zhang, S. Zhang, C.G. Yu, Z.M. Xu and X.P. Zou
A pair of inverted repeated sequences of the gene survivin was designed for stable double-stranded RNA establishment. After stable transfection, the biological behaviors of gastric cancer cells were observed. The interference rates of survivin-targeting siRNA (siRNA-survivin) in BGC823, MKN45, SGC7901, and ci.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.22
- DOI:
- 10.4238/2014.August.28.22
Prognostic significance of tumor-associated macrophage infiltration in gastric cancer: a meta-analysis
Authors: X.L. Wang, J.T. Jiang and C.P. Wu
Tumor-associated macrophages (TAMs), which play a crucial role in the tumor microenvironment, can be divided into M1 and M2 phenotypes, these phenotypes may exert opposite effects on the prognoses of patients with gastric cancer (GC). The association between TAMs and GC is contentious. Thus, a meta-analysis of 12 studies (inco.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049040
- DOI:
- 10.4238/gmr15049040
Analysis of ADH1B Arg47His, ALDH2 Glu487Lys, and CYP4502E1 polymorphisms in gastric cancer risk and interaction with environmental factors
Authors: Z.H. Chen, J.F. Xian and L.P. Luo
Gastric cancer is the fourth commonly diagnosed cancer and the second most frequent cause of cancer death worldwide. Genetic variations in ADH1B and ALDH2 may alter the function and activity of the corresponding enzymes, leading to differences in acetaldehyde exposure between drinkers. Cytochrome P4502E1 (CYP4502E1) is a phase.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048904
- DOI:
- 10.4238/gmr15048904
Investigation on the association between IL-10 C819T gene polymorphisms and susceptibility to gastric cancer
Authors: L. Li, X.Y. Tang, L.M. Ye, Q. Yang and Y. Li
We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People’s Hospital betwee.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047915
- DOI:
- 10.4238/gmr15047915
Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer
Authors: Z.H. Chen, L. Wang and L.P. Luo
We investigated the correlation between the response to chemotherapy in patients and excision repair cross-complimentary group 1 gene (ERCC1) and xeroderma pigmentosum complementation group F gene (XPF) polymorphisms and the effect of these polymorphisms on the clinical outcome of gastric cancer. Samples from a total of 255 patients with.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.15
- DOI:
- 10.4238/2014.September.12.15
Association of MLL3 expression with prognosis in gastric cancer
Authors: B. Li, H.Y. Liu, S.H. Guo, P. Sun, F.M. Gong and B.Q. Jia
Low expression of myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) is reportedly associated with gastric cancer and tumor progression. The purpose of this study was to examine the expression of MLL3 in tissue samples of patients with gastric cancer and to analyze the relationship between MLL3 protein expression and clinical.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.18
- DOI:
- 10.4238/2014.September.12.18