Gastric Cancer
Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression
Authors: Z. Peng and Y. Zhang
Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027078
- DOI:
- 10.4238/gmr.15027078
MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation
Authors: W. Peng, Z.-Y. Chen, L. Wang, Z. Wang and J. Li
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the translation of targeted mRNAs. An increasing amount of evidence indicates that miRNAs play important role in cancer pathogenesis, apoptosis, proliferation, and differentiation as oncogenes or tumor suppressors. Recently, miRNA-199a has been shown to be involved in many human cancers, although .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.5
- DOI:
- 10.4238/2013.August.20.5
Reduced expression of serum miR-204 predicts poor prognosis of gastric cancer
Authors: X. Chen, X.S. Liu, H.Y. Liu, Y.Y. Lu and Y. Li
Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027702
- DOI:
- 10.4238/gmr.15027702
Effect of cyclosporin A particles of varying diameters on gastric cancer cell apoptosis
Authors: X.L. Xing, Y. Lu and H.L. Qiu
Human health is significantly threatened by gastric cancer, which is the most common malignant tumor; although drastic, surgery is currently the only way to cure it. However, high recurrence rates and low survival rates are associated with the disease. Therefore, to improve the effectiveness of gastric cancer treatment and to .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028085
- DOI:
- 10.4238/gmr.15028085
Genetic variability of ERCC1 and ERCC2 genes involved in the nucleotide excision repair pathway influences the treatment outcome of gastric cancer
Authors: D.L. Zheng, G.D. Tang, Y.N. Chen, T. Zhang and M.B. Qin
We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platin.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027384
- DOI:
- 10.4238/gmr.15027384
Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer
Authors: S. Chen, X.C. Zhu, Y.L. Liu, C. Wang and K.G. Zhang
We carried out a hospital-based case-control study to investigate the role of XRCC1 gene Arg399Gln, Arg280His, and Arg194Trp polymorphisms in susceptibility to gastric cancer. A total of 214 gastric cancer patients and 247 control subjects were recruited between March 2013 and March 2015, and polymorphism genotype frequencies .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038342
- DOI:
- 10.4238/gmr.15038342
Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population
Authors: M. Li, R.J. Li, H. Bai, P. Xiao, G.J. Liu, Y.W. Guo and J.Z. Mei
We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People’s Hospita.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027516
- DOI:
- 10.4238/gmr.15027516
Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer
Authors: J.Y. Gu and L. Tu
Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027839
- DOI:
- 10.4238/gmr.15027839
IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis
Authors: Z. Li, Y. Liu, D. Cao, M. Jiang and F. Luo
We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.10
- DOI:
- 10.4238/2015.June.26.10
miR-218 tissue expression level is associated with aggressive progression of gastric cancer
Authors: X.X. Wang, S.J. Ge, X.L. Wang, L.X. Jiang, M.F. Sheng and J.J. Ma
The aim of the present study was to investigate the clinical significance of microRNA-218 (miR-218) in gastric cancer. We enrolled 112 patients having undergone surgery for gastric cancer between May 2008 and June 2014. Expression of miR-218 was determined by real-time quantitative reverse transcription-polymerase chain reacti.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027521
- DOI:
- 10.4238/gmr.15027521