Gastric Cancer
Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study anda meta-analysis
Authors: W.G. Hu, R.J. Pan, W. Cai, Z.T. Wang and Z.G. Zhu
The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-ana.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.31
- DOI:
- 10.4238/2015.November.18.31
ZNF797 plays an oncogenic role in gastric cancer
Authors: D. Momenzadeh1, S. Rahman Zadeh1, M. Rezaei-Tavirani1, A. Baradaran-Rafii2, F. Ghasemvand1 and S. Heidari-Keshel1
Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, selfrenewal. A complex network of transcription factors and signaling molecules are required for continuation of this trait. ZNF797 (SALL4) is a zinc finger transcriptional activator crucial for maintenance of self-renewal in stem cells; howe.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.18
- DOI:
- 10.4238/2014.October.20.18
Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer
Authors: W.T. Qi, J.L. Gao and S.S. Zhang
We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.33
- DOI:
- 10.4238/2015.October.26.33
Genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene in Chinese patients with gastric cancer
Authors: J. Liu X. Li N. Yu Y.-Q. Yang X. Li Z.-Y. Ye J.-C. Li
We explored a possible correlation of genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene with clinicopathologic features of gastric cancer in Chinese patients and looked for molecular markers for diagnosing gastric tumor development. Microsatellite instability and loss of heterozygosity of the PAI-1 gene locus D7S515, D7S471 .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.11
- DOI:
- 10.4238/2012.May.18.11
Dynamic relationship between SIPA1 gene and protein expression and the development of gastric cancer
Authors: J.Y. Li, J.B. Wang, C.B. Liu, D.L. Ma, J.H. Ma
Association of signal-induced proliferation-associated 1 (SIPA) gene and protein expression with gastric cancer development was examined. SIPA1 mRNA and protein levels were determined by real-time quantitative polymerase chain reaction and western blot, respectively, in 40 gastric tumor and tumor-adjacent normal tissues. SIPA1.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019271
- DOI:
- 10.4238/gmr16019271
Bioinformatics analysis with graph-based clustering to detect gastric cancer-related pathways
Authors: P. Liu X. Wang C.H. Hu T.H. Hu
Despite a dramatic reduction in incidence and mortality rates, gastric cancer still remains one of the most common malignant tumors worldwide, especially in China. We sought to identify a set of discriminating genes that could be used for characterization and prediction of response to gastric cancer. Using bioinformatics analysis, two gastric cancer datas.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.5
- DOI:
- 10.4238/2012.September.26.5
Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors
Authors: Z.H. Chen, J.F. Xian and L.P. Luo
Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals’ susceptibility to cancers. We aimed to investigate the asso.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018877
- DOI:
- 10.4238/gmr16018877
Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells
Authors: F.J. Ji, X.F. Tian, X.W. Liu, L.B. Fu, Y.Y. Wu, X.D. Fang,H.Y. Jin
The aim of the present study was to determine the antiproliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), la.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.7
- DOI:
- 10.4238/2015.December.1.7
Genetic variability of XRCC1 influences the treatment outcome of gastric cancer
Authors: H.Q. Hu1, F. Wang2, X. Du2, X.Z. Zhao2, Z. Jin2 and M.X. Hou2
We aimed to investigate the role of XRCC1 codon 194 (Arg>Trp), 280 (Arg>His), and 399 (Arg>Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients. A total of 172 patients were recruited for our study between January 2010 and March 2012. Genotyping of the three XRCC1 codons was carried out by restriction.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017452
- DOI:
- 10.4238/gmr.15017452
Apoptosis in different gastric lesions and gastric cancer: relationship with Helicobacter pylori, overexpression of p53 and aneuploidy
Authors: A.C. Targa, A.C.G. C�©sar, P.M. Cury, A.E. Silva
Apoptosis has an essential function in maintaining the integrity of the gastrointestinal mucosa. Its deregulation is associated with the occurrence of lesions such as in atrophic gastritis, peptic ulcers, intestinal metaplasia, and stomach tumorigenesis. Thus, the aim of the present study was to investigate the frequency of ap.. Read More»
- Genet. Mol. Res. 6(3):