Gastric Cancer
c-erbB-2 expression and prognosis of gastric cancer: a meta-analysis
Authors: Z.Q. Wang and B.J. Sun
The prognostic role of c-erbB-2 in gastric cancer is controversial. We conducted a meta-analysis to evaluate the relationship between c-erbB-2 expression and the prognosis of gastric cancer. We evaluated 20 published studies assessing the relationship between c-erbB-2 and gastric cancer prognosis. The Revman 5.0 software was used to perform literature ret.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.5
- DOI:
- 10.4238/2015.March.13.5
EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population
Authors: J.H. Torres-Jasso, M.E. MarÃ?Ân, E. Santiago-Luna, J.C. Leoner,J. Torres, M.T. MagaÃ?±a-Torres, F.J. Perea, B. Ibarra and J.Y. SÃ?¡nchez-LÃ?³pez
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine-kinase activity that plays an important role in multiple cellular functions. EGFR overexpression has been observed in several types of tumors and it is significantly associated with disease stage, survival, prognosis, and progression of cancer. The polymorphisms -216G>.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.8
- DOI:
- 10.4238/2015.March.13.8
Interleukin-1B-31 gene polymorphism in Hakka gastric cancer patients in Guangdong, China
Authors: B. Qiu, H.-Y. Zou, Y.-H. Yang and C.-F. Lai
The aim of this study was to examine the interleukin-1B (IL-1B) gene promoter region -31 (IL-1B-31) polymorphism distribution characteristic of Hakka gastric cancer patients in Guangdong Province and to explore its association with gastric cancer. We used the 1:1 case-control method, matrix-assisted laser desorption ionization.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.2
- DOI:
- 10.4238/2014.August.7.2
Effects of simulated weightlessness on cellular morphology and biological characteristics of cell lines SGC-7901 and HFE-145
Authors: M. Zhu, X.W. Jin, B.Y. Wu, J.L. Nie and Y.H. Li
We investigated the effects of simulated weightlessness on cellular morphology, proliferation, cell cycle, and apoptosis of the human gastric carcinoma cell line SGC-7901 and the human gastric normal cell line HFE-145. A rotating clinostat was used to simulate weightlessness. The Image-Pro4.5 image analysis system was used for.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.20
- DOI:
- 10.4238/2014.August.7.20
Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and X.Q. Yue
Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasionwere detected by MTT assay, flow c.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.20
- DOI:
- 10.4238/2015.July.17.20
Pharmacogenetic role of XRCC1 polymorphisms on the clinical outcome of gastric cancer patients with platinum-based chemotherapy: a systematic review and meta-analysis
Authors: J. Xu, J. Ma, H.T. Zong, S.Y. Wang and J.W. Zhou
It is still controversial whether X-ray repair cross-complementing group (XRCC1) gene polymorphisms (Arg194Trp and Arg399Gln) are associated with the clinical outcome of platinum-based chemotherapy in gastric cancer patients based on published studies. Meta-analysis was performed to provide a systematic review of the findings... Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.6.2
- DOI:
- http://dx.doi.org/10.4238/2014.March.6.2
Epstein-Barr virus DNA associated with gastric adenocarcinoma and adjacent non-cancerous mucosa in patients from Manaus, Brazil
Authors: P.F. de Aquino P.C. Carvalho J.S. da Gama Fischer A.Q.L. de Souza J.S. Viana S.R.S. Chalub A.D.L. de Souza M.G.C. Carvalho
Gastric cancer is one of most frequent causes of death in Brazil. The city of Manaus has one of the highest incidences of this disease in Brazil. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is classified as a group 1 carcinogen by the International Agency for Research on Cancer. We obtained biopsies from 6 control subjects and 10 patient.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.3
- DOI:
- 10.4238/2012.October.15.3
Investigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population
Authors: L.Q. Yang, Y. Zhang and H.F. Sun
Our study aimed to investigate the role of 2 ERCC5 promoter SNPs (rs2094258 and rs751402) in the development of gastric cancer in the Chinese population. The present hospital-based case-control study consisted of 155 patients with gastric cancer and 246 healthy controls recruited between March 2012 and December 2014. Genotyping for the rs2094258 and rs751.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038364
- DOI:
- 10.4238/gmr.15038364
Comparative study of clinical efficacy of laparoscopy-assisted radical gastrectomy versus open radical gastrectomy for advanced gastric cancer
Authors: L.M. Wu, X.J. Jiang, Q.F. Lin and C.X. Jian
The purpose of this study is to compare the efficacy of laparoscopy-assisted radical gastrectomy (LARG) versus that of open radical gastrectomy (ORG). Clinical data of 355 patients who underwent radical gastrectomy (160 in the LARG group and 195 in the ORG group) were analyzed retrospectively. Efficacy indices were compared and analyzed between the two gr.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.9
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.9
Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration
Authors: X.S. Li and X.L. He
Abnormal expression of the kallikrein (KLK) family of serine proteases closely correlates with onset, progression, and prognosis of endocrine gland-related malignant tumors. The aim of this study was to evaluate how downregulation of KLK12 influenced cell cycle and proliferation of the AGS gastric cancer cell line. KLK12 was d.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038452
- DOI:
- 10.4238/gmr.15038452