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The clinical significance of miR-7-5p downregulation in gastric dysplasia and gastric cancer tissue

Author(s): Sara Omrani, Ali Zare, Shahriar Tarighi, Hamid Ghaedi, Mir Davood Omrani

miRNAs have been involved in the pathogenesis of several cancers such as gastric cancer (GC.). In the following study we analyzed the expression of miR-7 in gastric cancer samples compared non-tumor tissues and gastric dysplasia (GD) samples with patients’ clinico-pathological data and its potential as diagnostic biomarker. We first analyzed its expression by real-time qRT– PCR in human GD and GC tissues, in which it was greatly downregulated in each compared with the control non-tumor tissues. The current study supports participation of miRNA miR-7-5p in the pathogenesis of gastric cancer and highlights their potential as diagnostic biomarker.