Human Genetics
Relevance of Additive and Nonadditive Genetic Relatedness for Genomic Prediction in Rice Population under Recurrent Selection Breeding
Authors: Odilon P. Morais J?ºnior, Jo?£o Batista Duarte, Fl?¡vio Breseghello, Alexandre S. G. Coelho, Tereza C. O. Borba, Jordene T. Aguiar, P?©ricles C. F. Neves, and Orlando P. Morais
In genomic recurrent selection programs of self-pollinated crops, additive genetic effects (breeding values) are effectively relevant for selection of superior progenies as new parents. However, considering additive and nonadditive genetic effects can improve the prediction of genome-enhanced breeding values (GEBV) of progenie.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039849
- DOI:
- 10.4238/gmr16039849
Molecular Diagnosis of X-Fragile Syndrome: Perspectives for the Public Health System in the Central Region of Brazil
Authors: K.B. Penteado, C.I.S. Gressler, A.D. Da Cruz, T.C. Vieira, & M.A. D. Gigonzac
X-Fragile Syndrome (FXS) is the most common cause of inherited intellectual disability and the second of genetic origin, with an estimated prevalence of 1/4000 men and 1/6000 women. The etiology is associated with a trinucleotide expansion of CGG sequences and hypermethylation of the promoter region of the FMR1 (Fragile-X Ment.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039848
- DOI:
- 10.4238/gmr16039848
The effect of EPS to LPS injure RAW264.7 cell NF-?ºB and MAPK signaling pathway
Authors: Q.D. Jiang, X.G. Zhou, Xiao.Z, X.P. Li and F.R. Nie
This study effects of Echinacea polysaccharide(EPS) to Lipopolysaccharides(LPS) injure RAW264.7 cell NF-κB and MAPK signaling pathway. The test was divided into blank groupã?LPS group and 100 mu g/mL EPS + LPS group, The respectively extract Cytoplasm protein and nucleoprotein. After Gel electrophoresis, the Western .. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039846
- DOI:
- 10.4238/gmr16039846
Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological approaches for precision medicine
Authors: Fehmida Bibi, Peter Natesan Pushparaj, Muhammad I. Naseer, Muhammad yasir, Esam I. Azhar
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate the differential expression of genes. The expression of miRNAs is dysregulated in various types of cancers, including Gastric Cancer (GC), and has both prognostic and diagnostic potential. To interpret the role of miRNA expression in GC, we evaluated the expre.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039845
- DOI:
- 10.4238/gmr16039845
Pseudo deficiency of acid ?±-glucosidase: a challenge in the newborn screening for Pompe diseases
Authors: Diana Rojas M?¡laga, Ana C. Brusius-Facchin, Kristiane Michelin-Tirelli, T?ªmis M. F?©lix, Jaqueline Schulte, Jamile Pereira, Eurico Camargo Neto, Claudio Sampaio Filho, Roberto Giugliani.
When a low activity of acid α-glucosidase (GAA) is found, particularly in newborn screening programs, to differentiate α-glucosidase pseudo deficiency from true Pompe disease is important and urgent, as the result generates parental stress and also because this differentiation drives decisions related to the manage.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039844
- DOI:
- 10.4238/gmr16039844
Single Nucleotide Polymorphisms associated with growth and carcass traits located on QTL Regions previously associated with Bovine Respiratory Disease
Authors: S. Mizell, S.L. Miller, A.M. Royer, K.J. Thornton, and M.D. Garcia
The objective of the current study was to evaluate single nucleotide polymorphisms (SNP) for potential growth and carcass trait associations located in two previously described quantitative trait loci (QTL) regions associated with bovine respiratory disease. A population of 323 crossbred steers sired by five purebred sire bree.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039843
- DOI:
- 10.4238/gmr16039843
Identification of Klf6-Related Super Enhancer in Human Hepatoma (HepG2) Cells by CRISPR Technique
Authors: Kum Chol Ri*, Jong Su Kim, Chol Kim
The Klf6 gene is a tumor suppressor gene belonging to the family of the Klf gene and closely associated with tumor formation. Recently, super enhancers(SEs) have been shown to play a particularly important role in regulating cell identity and are attempting to evaluate the in vivo function of SEs. But direct functional evidenc.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039841
- DOI:
- 10.4238/gmr16039841
Intestinal Dysbiosis Increases the Incidence of Malignant Melanoma in Mice Model
Authors: Xiaomeng Ren, Xin Zhang, Yanyan Zhu, Yaser Gamallat, Abdo Meyiah, Shenhao Ma, Yi Xin
Antibiotic-induced disruption of the intestinal microbiota has serious consequences for human physiology. We conducted a microbial dysbiosis animal model to study and directly provide evidence for microbial dysbiosis contribution to malignant melanoma animal model. Females C57BL/6 wild-type (WT) mice injected with a limiting t.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039840
- DOI:
- 10.4238/gmr16039840
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Authors: R.S. Mascarenhas, F.R.B. Oliveira, J.F. Corr?ªa, K.S.F. e Silva, I.R. Costa, A.M. Barbosa, M.H. Lagares, F.L. Campedelli, M.P. de Morais, J.V.M. Martins, D.A. Rodrigues, e K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039836
- DOI:
- 10.4238/gmr16039836
Protein Z gene variants and risk of Idiopathic Recurrent Pregnancy Loss in Saudi Arabian women
Authors: Walid Zammiti, Sarra Said, Amani Shaman, Faisel Mohammed Abu-Duhier
Background: Protein Z (PZ) is a vitamin K-dependent plasma glycoprotein, it plays a key role in the physiologic inhibition of coagulation by acting as a cofactor in the inactivation of factor Xa. The relationship between PZ gene polymorphisms and pregnancy loss is controversial. To address this, we investigate the association .. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039834
- DOI:
- 10.4238/gmr16039834