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Single Nucleotide Polymorphisms associated with growth and carcass traits located on QTL Regions previously associated with Bovine Respiratory Disease

Author(s): S. Mizell, S.L. Miller, A.M. Royer, K.J. Thornton, and M.D. Garcia

The objective of the current study was to evaluate single nucleotide polymorphisms (SNP) for potential growth and carcass trait associations located in two previously described quantitative trait loci (QTL) regions associated with bovine respiratory disease. A population of 323 crossbred steers sired by five purebred sire breeds between 2010-2013 (Angus, Braford, Braunvieh, Charolais, and Simmental) were evaluated from birth until harvest. Eighty-two SNP were evaluated in the current study for potential significant associations with growth and carcass traits (58 on BTA6 and 24 on BTA20). A total of nine unique SNP (rs41595713, rs42403565, rs42571566, rs42900130, rs41931108, rs42480445, rs43451134, rs42524450, rs41626155) were significantly associated (P < 0.05) with specific growth traits such as birth weight, weaning weight and hip height. Six of these significant SNP were located on BTA6 and three were located on BTA20. When evaluating the carcass traits hot carcass weight (HCW), yield grade (YG), marbling score (MARB), and rib eye area (REA) a total of nine unique SNP (rs42900130, rs42961882, rs43446022, rs41931108, rs41595713, rs41653357, rs43036576, rs42823614, rs42512588) were significantly associated (P < 0.05) with carcass traits. For both of these regions, animals inheriting differing genotypes from the previously described SNP, had significantly different levels of performance for specific growth and carcass traits. Although multiple SNP were identified as significant with growth and carcass traits, these SNP identified herein must be validated in a larger more diverse population prior to implementation into marker assisted selection programs