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Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus

Author(s): R.S. Mascarenhas, F.R.B. Oliveira, J.F. Corrêa, K.S.F. e Silva, I.R. Costa, A.M. Barbosa, M.H. Lagares, F.L. Campedelli, M.P. de Morais, J.V.M. Martins, D.A. Rodrigues, e K.K.V.O. Moura

Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of atherosclerosis. Such diseases also have a genetic imprint on their genesis, such as the GSTM1 and GSTT1 gene polymorphisms. The present study aimed to perform the molecular analysis of GSTM1 and GSTT1 gene polymorphisms in atherosclerotic hypertensive patients, atherosclerotic patients with diabetes, atherosclerotic patients with hypertension and diabetes, and the control group. We analyzed 100 samples of hypertensive atherosclerotic individuals, 54 atherosclerotic individuals with diabetes and 23 atherosclerotic individuals with hypertension and diabetes. The samples were subjected to DNA extraction, then PCR and analyzed on 1.5% agarose gel stained with ethidium bromide. The results were compared through the Chi-Square Test. We found a significant frequency of the GSTM1 present genotype in the hypertensive atherosclerotic group (p=0.025), the present form of the GSTT1 gene was significant in all of the three groups studied (p=0.006 in the hypertensive atherosclerotic group, p = 0.003 in the diabetic atherosclerotic group and p=0.039 in the hypertensive and diabetic atherosclerotic group). The results show a relationship between the present genotype of GSTM1 and hypertension, and that the present form of GSTT1 is related to the development of atherosclerosis, regardless of the related cofactor


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