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Human Genetics   Research Article
Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer

Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy

Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer .. Read More»

Genet. Mol. Res. 18(1):

Animal Genetics   Research Article
Potential Protective Effect of Vitamin D on Cardiac Extrinsic pathways of apoptosis in Male Rats Fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zainab Al-refaie, Hossam Awad, Mahmood Rasool

Background: Obesity and vitamin D deficiency are increasing in Kingdom of Saudi Arabia (KSA) in last decades. Researchers have shown a relation between both disorders and cardiovascular disease (CVD). The present work aimed to investigate the possible protective effect of vitamin D on cardiac apoptosis in rats fed with a high fat diet. Methods: This study.. Read More»

Genet. Mol. Res. 18(1):

Medical Genetics   Research Article
Possible association of proinflammatory cytokine IL-19 gene polymorphism with psoriasis

Authors: Wani Aadil, Bashir Ahmad Ganai, Tahseena Akhtar Tarun Narang, Rajinder Kaur

Background: Interleukin (IL-19) a member of the IL-10 family involved in abnormal keratinocyte differentiation and proliferation which is the hall mark of psoriasis. Aim: The aim of this study was to investigate the association between IL-19 gene polymorphism in patients with chronic plaque psoriasis as a factor in the susceptibility and developme.. Read More»

Genet. Mol. Res. 18(1):

Animal Genetics   Research Article
Molecular insights of mitochondrial 16S rDNA genes of the native honey bees subspecies Apis mellifera carnica and Apis mellifera jementica (Hymenoptera: Apidae) in Saudi Arabia

Authors: Reem Alajmi, Rewaida Abdel-Gaber, Loloa Alfozana

The honey bee Apis mellifera is of major importance for the world’s agriculture and is also suitable for environmental monitoring. It includes several recognized subspecies distinguished by using morphological and morphometric variants. Here, 200 adult worker Apis mellifera honey bees were collected from Hail region, Saudi Arabia. Mitochondrial 16S .. Read More»

Genet. Mol. Res. 18(1):

Medical Genetics   Research Article
Expression analysis of OIP5-AS1 in bladder tissues

Authors: Feraydoon Abdolmaleki, Soudeh Ghafoui-Fard, Mohammad Taheri, Alireza Mordadi, Mandana Afasharpad, Abolghasem Nikfallah, Bashir Nazparvar, Vahid Kholghi Oskooei, Mir Davood Omrani

Long non-coding RNAs (lncRNAs) have crucial roles in regulation of many aspects of cell functions which are related with carcinogenesis process. The lncRNA Opa Interacting Protein 5-antisense 1 (OIP5-AS1) is among lncRNAs whose roles in some human malignancies have been elucidated. In the current study, we aimed at identification of the role of this lncRN.. Read More»

Genet. Mol. Res. 18(1):

Human Genetics   Review Article
Integrative omics of ovarian cancer

Authors: Yanisa Rattanapan and Takol Chareonsirisuthigul

Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of c.. Read More»

Genet. Mol. Res. 18(1):

Human Genetics   Research Article
Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer

Authors: Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard

Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues.. Read More»

Genet. Mol. Res. 18(1):

Medical Genetics   Research Article
The clinical significance of miR-7-5p downregulation in gastric dysplasia and gastric cancer tissue

Authors: Sara Omrani, Ali Zare, Shahriar Tarighi, Hamid Ghaedi, Mir Davood Omrani

miRNAs have been involved in the pathogenesis of several cancers such as gastric cancer (GC.). In the following study we analyzed the expression of miR-7 in gastric cancer samples compared non-tumor tissues and gastric dysplasia (GD) samples with patients’ clinico-pathological data and its potential as diagnostic biomarker. We first analyzed its exp.. Read More»

Genet. Mol. Res. 18(1):