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Human Genetics   Research Article
Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer

Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy

Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer .. Read More»

Genet. Mol. Res. 18(1):

Animal Genetics   Research Article
Potential Protective Effect of Vitamin D on Cardiac Extrinsic pathways of apoptosis in Male Rats Fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zainab Al-refaie, Hossam Awad, Mahmood Rasool

Background: Obesity and vitamin D deficiency are increasing in Kingdom of Saudi Arabia (KSA) in last decades. Researchers have shown a relation between both disorders and cardiovascular disease (CVD). The present work aimed to investigate the possible protective effect of vitamin D on cardiac apoptosis in rats fed with a high fat diet. Methods: This study.. Read More»

Genet. Mol. Res. 18(1):

Medical Genetics   Research Article
Possible association of proinflammatory cytokine IL-19 gene polymorphism with psoriasis

Authors: Wani Aadil, Bashir Ahmad Ganai, Tahseena Akhtar Tarun Narang, Rajinder Kaur

Background: Interleukin (IL-19) a member of the IL-10 family involved in abnormal keratinocyte differentiation and proliferation which is the hall mark of psoriasis. Aim: The aim of this study was to investigate the association between IL-19 gene polymorphism in patients with chronic plaque psoriasis as a factor in the susceptibility and developme.. Read More»

Genet. Mol. Res. 18(1):

Medical Genetics   Research Article
Expression analysis of OIP5-AS1 in bladder tissues

Authors: Feraydoon Abdolmaleki, Soudeh Ghafoui-Fard, Mohammad Taheri, Alireza Mordadi, Mandana Afasharpad, Abolghasem Nikfallah, Bashir Nazparvar, Vahid Kholghi Oskooei, Mir Davood Omrani

Long non-coding RNAs (lncRNAs) have crucial roles in regulation of many aspects of cell functions which are related with carcinogenesis process. The lncRNA Opa Interacting Protein 5-antisense 1 (OIP5-AS1) is among lncRNAs whose roles in some human malignancies have been elucidated. In the current study, we aimed at identification of the role of this lncRN.. Read More»

Genet. Mol. Res. 18(1):

Medical Genetics   Research Article
NNT and NNT-AS1 expression levels are not different between bipolar patients and healthy subjects

Authors: Soudeh Ghafouri-Fard, Mohammad Taheri, Vahid Kholghi Oskooie, Mir Davood Omrani, Arezou Sayad

Nicotinamide nucleotide transhydrogenase (NNT) participates in redox and energy interconnections. Nnt silencing in N27 dopaminergic cells has changed basal, extra, and greatest mitochondrial oxygen absorption rates and made these cell vulnerable to constant upsurges in H2O2. NNT-antisense RNA1 (NNT-AS1) is transcribed from the opposite stand of NNT gene a.. Read More»

Genet. Mol. Res. 18(1):

Human Genetics   Case Reports
Glioblastoma in a 20-year-old female patient after Chikungunya infection

Authors: L.O. Mourão, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves

We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX pos.. Read More»

Genet. Mol. Res. 18(1):

Plant Genetics   Research Article
Genetic diversity, agronomic potential and reaction to downy mildew in genotypes of biofortified mini lettuce

Authors: A.C.P. Jacinto, A.J. Silveira, R. Castoldi, G.M. Maciel, A.C.S. Siquieroli and T.F.N. Mendonça, A.P. Souza, M.V. Marin, L.T. Braz

Lettuce is one of the most consumed leaf vegetables in the world, highlighting itself as a novelty in the market as mini type cultivars. During the winter the downy mildew can lead to severe damage. Thus, the objective of this work was to evaluate the genetic diversity, agronomic potential and downy mildew reaction in biofortified mini lettuce genotypes. .. Read More»

Genet. Mol. Res. 18(1):

Plant Genetics   Research Article
Genetic inheritance of traits relating to seedling and size in ornamental pepper

Authors: Angela Maria dos Santos Pessoa, Elizanilda Ramalho do Rêgo, Michelle Gonçalves de Carvalho, Cristine Agrine Pereira dos Santos, Júlio Carlos Polimeni de Mesquita, Mailson Monteiro do Rêgo

Pepper exhibits genetic diversity and versatility in use. Knowledge of the genetic control of traits in peppers is of great importance to breeding programs given the variety of types, sizes, colors and flavors. The aim of the present study was to examine the inheritance of seedling and plant traits in ornamental pepper (Capsicum annuum). The experiment wa.. Read More»

Genet. Mol. Res. 18(1):