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Possible association of proinflammatory cytokine IL-19 gene polymorphism with psoriasis

Author(s): Wani Aadil, Bashir Ahmad Ganai, Tahseena Akhtar Tarun Narang, Rajinder Kaur

Background: Interleukin (IL-19) a member of the IL-10 family involved in abnormal keratinocyte differentiation and proliferation which is the hall mark of psoriasis.

Aim: The aim of this study was to investigate the association between IL-19 gene polymorphism in patients with chronic plaque psoriasis as a factor in the susceptibility and development of psoriasis.

Subjects and Methods: 200 psoriatic patients and 200 controls were genotyped for three IL-19 polymorphic sites by Amplification Refractory Mutation System polymerase chain reaction (ARMS-PCR).

Results: Our results demonstrated that polymorphism of IL-19-42232 C/A (rs2243188) adjusted* OR=0.59; (95% CI=0.25 – 1.40)and IL-19-38386 T/C (rs2073186) adjusted* OR=1.28; (95% CI=0.70 – 2.35) does not show any significant association with risk of psoriasis while as IL-19 -35402 G/C (rs2243158) adjusted* OR=2.05; (95% CI=1.19 – 3.55) was found to be in association with increased risk of psoriasis. HT3 ACG OR=0.41; (95% CI=0.20- 0.84) haplotype is associated with decreased risk of psoriasis.

Limitations: Small sample size. A large epidemiological study is required to confirm these findings. Family based studies and association studies of different populations are required to confirm the impact of IL-19 in genetic predisposition of psoriasis.

Conclusion: IL-19 polymorphism have considerable role towards the susceptibility of psoriasis in north Indian population. Evaluating the role of IL-19 cytokine in pathogenesis of psoriasis will prove supportive for the development of psoriasis management.