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We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX positive, Ki-67 positive in 35% of neoplastic cells, and p53 and synaptophysin negativity. No mutations of the suppressor gene TP53 (exons 4-10) or in the hotspots of the oncogenes NRAS/KRAS (exons 1-2) were found in the tumor, and the MGMT promoter was hypermethylated. Our patient was not subject to any known cancer risk factors, but our findings suggest the contribution of CHIKV and CMV for the fast tumor progress.