NNT and NNT-AS1 expression levels are not different between bipolar patients and healthy subjects

Author(s): Soudeh Ghafouri-Fard, Mohammad Taheri, Vahid Kholghi Oskooie, Mir Davood Omrani, Arezou Sayad

Nicotinamide nucleotide transhydrogenase (NNT) participates in redox and energy interconnections. Nnt silencing in N27 dopaminergic cells has changed basal, extra, and greatest mitochondrial oxygen absorption rates and made these cell vulnerable to constant upsurges in H2O2. NNT-antisense RNA1 (NNT-AS1) is transcribed from the opposite stand of NNT gene and is possibly involved in regulation of NNT expression. Based on the reports of previous studies regarding dys-regulation of oxidative stress markers in bipolar patients, we designed the current study to assess peripheral expression of NNT and NNT-AS1 in bipolar patients and healthy subjects. Transcript levels of NNT and NNT-AS1 were not significantly different between bipolar patients and controls. No significant correlation was found between relative expression of genes and age of study participants. Moreover, expression of either gene was correlated with age at disease onset or disease duration in cases. However, significant pairwise correlation was found between expressions of these genes in bipolar patients. Our results imply that NNT does not participate in dys-regulation of oxidative stress in bipolar disease.


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