Table of Contents | Genet. Mol. Res.2013(2)
ATP-dependent chromatin remodeling and histone acetyltransferases in 5-FU cytotoxicity in Saccharomyces cerevisiae
Authors: R. Matuo, F.G. Sousa, D. Bonatto, A.A. Mielniczki-Pereira, J. Saffi, D.G. Soares, A.E. Escargueil, A.K. Larsen and J.A.P. Henriques
Chromatin is thought to modulate access of repair proteins to DNA lesions, and may be altered by chromatin remodelers to facilitate repair. We investigated the participation of chromatin remodelers and DNA repair in 5-fluorouracil (5-FU) cytotoxicity in Saccharomyces cerevisiae. 5-FU is an antineoplastic drug commonly used in clinical settings. Among the .. Read More»
Genet. Mol. Res. 12(2): 2013.April.26.6
DOI: 10.4238/2013.April.26.6
Genes associated with disc degeneration identified using microarray gene expression profiling and bioinformatics analysis
Authors: Y. Chen, K. Chen, M. Li, C. Li, H. Ma, Y.S. Bai, X.D. Zhu and Q. Fu
Disc degeneration is strongly associated with back or neck pain, sciatica, and disc herniation or prolapse. It places an enormous economic burden on society and can greatly affect quality of life. Alternative treatment approaches, such as genetic therapies, are urgently needed to slow or reverse the disc degeneration process. We downloaded gene expression.. Read More»
Genet. Mol. Res. 12(2): 2013.April.26.5
DOI: 10.4238/2013.April.26.5
Updated analysis of studies on the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and Hashimoto�s thyroiditis risk
Authors: R. Ji, Y. Feng and W.W. Zhan
Published data on the association between the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and the risk for Hashimoto’s thyroiditis (HT) are inconclusive. A meta-analysis was performed to derive a more precise estimation. Published case-control studies in English or Chinese were identified. In total, 24 studies with 2295 cases .. Read More»
Genet. Mol. Res. 12(2): 2013.April.26.4
DOI: 10.4238/2013.April.26.4
Peroxidase is involved in Pepper yellow mosaic virus resistance in Capsicum baccatum var. pendulum
Authors: L.S.A. Gon�§alves, R. Rodrigues, M.S.S. Diz, R.R. Robaina, A.T. do Amaral J�ºnior, A.O. Carvalho and V.M. Gomes
Pathogenesis-related proteins (PRs) are among the defense mechanisms of plants that work as an important barrier to the development of pathogens. These proteins are classified into 17 families according to their amino acid sequences, serology, and/or biological or enzyme activity. The present study aimed to identify PRs associated with the pathosystem of .. Read More»
Genet. Mol. Res. 12(2): 2013.April.26.3
DOI: 10.4238/2013.April.26.3
Target replacement strategy for selection of DNA aptamers against the Fc region of mouse IgG
Authors: J. Ma, M.G. Wang, A.H. Mao, J.Y. Zeng, Y.Q. Liu, X.Q. Wang, J. Ma, Y.J. Tian, N. Ma, N. Yang, L. Wang and S.Q. Liao
Aptamers that recognize the IgG Fc region are of great interest because of their wide application as an immunology probing tool, for diagnostics, and as affinity agents for antibody purification. We developed a target replacement strategy as a modification of conventional Systematic Evolution of Ligands by EXponential enrichment (SELEX) in order to effici.. Read More»
Genet. Mol. Res. 12(2): 2013.April.25.11
DOI: 10.4238/2013.April.25.11
Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine
Authors: D.F. Jiang, X.G. Zhang, H.L. Yang and C. Sun
Evodiamine is the main active alkali of Wu Zhuyu, a widely distributed Chinese herb. It plays an important role in the regulation of body fat deposition. In this study, we aimed to investigate the effect of evodiamine administration on the expression of genes involved in lipid metabolism in the liver and adipose tissue. Fasted mice were subcutaneously inj.. Read More»
Genet. Mol. Res. 12(2): 2013.January.4.13
DOI: 10.4238/2013.January.4.13
An SduI polymorphism at intron 20 of the Chinese Holstein cow STAT4 gene and its effect on milk performance traits
Authors: X.M. Song, L. Zhang, J.F. Jiang, F.X. Shi and Y.Q. Jiang
The signal transducer and activator of transcription (STAT) genes are responsive to a wide range of cytokines, growth factors, and hormones, and thus control important biological processes. In humans, STAT4 mutations have been identified as genetic markers for rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren’s syndrome, w.. Read More»
Genet. Mol. Res. 12(2): 2013.May.13.13
DOI: 10.4238/2013.May.13.13
Molecular cloning of the perilipin gene and its association with carcass and fat traits in Chinese ducks
Authors: H.L. Zhang, H.J. Fan, X.L. Liu, Y. Wu and S.S. Hou
The perilipin (PLIN) gene is a candidate gene of carcass and fat traits in ducks. In order to study the molecular character of the PLIN gene and its function in different breeds of Chinese ducks, samples were obtained from the Chinese Academy of Agricultural Sciences Research Center for Birds, including 95 Peking ducks of the Z2 series, 91 Peking ducks of.. Read More»
Genet. Mol. Res. 12(2): 2013.May.13.12
DOI: 10.4238/2013.May.13.12