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Cytogenomics   Research Article

Genetic contribution of CYP2C9, CYP2C19, and APOE variants in acenocoumarol response

Authors: J.A. Nastasi-Catanese1, J.R. Padilla-Gutiérrez2, Y. Valle2, F. Ortega-Gutiérrez3, M.P. Gallegos-Arreola4 and L.E. Figuera5,6

Oral anticoagulants of the coumarin type have an inconveniently narrow therapeutic window, making their use difficult. In Mexico, genetic variables that participate in the heterogeneity of the therapeutic response remain poorly investigated. With the focus on warfarin, extensive pharmacogenomic studies have been performed, including those on the CYP450 fa.. Read More»

Genet. Mol. Res. 12(4):
2013.October.10.7
DOI:
10.4238/2013.October.10.7
Cytogenomics   Research Article

Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis

Authors: G. Lin, J. Zhao, J. Wu, R. Andreevich O, W.-H. Zhang, Y. Zhang and L. Yu

Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. Recent epidemiological studies have investigated the correlation of COMT Val158Met polymorphism with endometrial cancer risk; however, the results are inconsistent. To better.. Read More»

Genet. Mol. Res. 12(4):
2013.December.10.5
DOI:
10.4238/2013.December.10.5
Cytogenomics   Research Article

Expression analysis of VfDGAT2 in various tissues of the tung tree and in transgenic yeast

Authors: Q.Q. Cui*, Y.C. Chen, X.J. Han, Z.Y. Zhan, L.Y. Lin, L.L. Si and Y.D. Wang

The tung tree (Vernicia fordii Hemsl.; Vf) has great potential as an industrial crop owning to its seed oil that has multiple uses. Diacylglycerol acyltransferases (DGATs) catalyze the last and most committed step of triacylglycerol (TAG) biosynthesis. In order to examine the physiological role of the VfDGAT2 gene in the tung tree, we characterized its ex.. Read More»

Genet. Mol. Res. 12(4):
2013.December.11.7
DOI:
10.4238/2013.December.11.7
Cytogenomics   Research Article

Trypsin inhibitors from Capsicum baccatum var. pendulum leaves involved in Pepper yellow mosaic virus resistance

Authors: M.M. Moulin1, R. Rodrigues1, S.F.F. Ribeiro2, L.S.A. Gonçalves3, C.S. Bento1, C.P. Sudré1, I.M. Vasconcelos4 and V.M. Gomes2

Several plant organs contain proteinase inhibitors, which are produced during normal plant development or are induced upon pathogen attack to suppress the enzymatic activity of phytopathogenic microorganisms. In this study, we examined the presence of proteinase inhibitors, specifically trypsin inhibitors, in the leaf extract of Capsicum baccatum var. pen.. Read More»

Genet. Mol. Res. 13(4):
Cytogenomics   Research Article

Sequence variation and molecular evolution of BMP4 genes.

Authors: D.J. Zhang, J.H. Wu2,, G. Husile, H.L. Sun and W.G. Zhang.

Bone morphogenetic protein 4 (BMP4) regulates skeletogenesis, osteoblastic differentiation, and the induction of hair follicles. Its protein-coding region contains a signal peptide, prodomain (which regulates post-translational synthesis), and a mature domain (which mediates gene function). Previous studies considered this gene to be conserved. By reanaly.. Read More»

Genet. Mol. Res. 13(4):
Cytogenomics   Research Article

Polymorphism of MyoD1 and Myf6 genes and associations with carcass and meat quality traits in beef cattle

Authors: X.H. Du, Q.F. Gan, Z.R. Yuan, X. Gao, L.P. Zhang, H.J. Gao,J.Y. Li and S.Z. Xu1

Myogenic determination factor 1 (MyoD1) and myogenic factor 6 (Myf6) genes belong to the myogenic differentiation (MyoD) gene family, which play key roles in growth and muscle development. The study aimed to investigate the effects of variants in cattle MyoD1 and Myf6 on carcass and meat traits. We screened single nucleotide polymorphisms (SNPs) of both g.. Read More»

Genet. Mol. Res. 12(4):
dx.doi.org/2013.December.13.4
DOI:
dx.doi.org/10.4238/2013.December.13.4
Cytogenomics   Research Article

MULTINDELS-BOV: Zebu traceback method based on DNA insertion-deletion polymorphisms

Authors: M. Groenner-Penna1,2, E.F.D. Croce1, C.G. Pimenta1, H.M.S. Bicalho1 and S.D.J. Pena

Brazil is a major producer and exporter of beef, with a herd of approximately 210 million animals. For the meat industry, a reliable animal traceback from its origin to the consumer market is paramount. Of all available identification systems, DNA is the only one that survives the slaughterhouse and reaches the dish of the consumer. DNA polymorphisms are .. Read More»

Genet. Mol. Res. 13(4):
Cytogenomics   Research Article

Impact of climatic factors on genetic diversity of Stipa breviflora populations in Inner Mongolia

Authors: Q. Zhang, J.M. Niu, S.B. Wu, A. Buyantuyev and J.J. Dong

Genetic diversity of Stipa breviflora populations in the Inner Mongolian grasslands of China and its possible correlation with climatic factors was examined using geographic information systems and random amplified polymorphism DNA analysis. A total of 308 bands were produced with 28 arbitrary decamer oligonucleotide. Three major findings were demonstrate.. Read More»

Genet. Mol. Res. 11(3):
2012.August.6.12
DOI:
10.4238/2012.August.6.12
Cytogenomics   Research Article

Cytogenetics of the darkling beetles Zophobas aff. confusus and Nyctobates gigas (Coleoptera, Tenebrionidae)

Authors: A.C. Lira-Neto, G.M. Silva, R.C. Moura and M.J. Souza

Males of Zophobas aff. confusus and Nyctobates gigas (Tenebrionidae) collected in the State of Pernambuco, Brazil, were studied through conventional staining, C-banding, silver nitrate impregnation (AgNO3), and the base specific fluorochromes CMA3 and DAPI. Z. aff. confusus was found to have 2n = 20 (9+Xyp) while N. gigas exhibited 2n = 18 (8+neoXY). Larg.. Read More»

Genet. Mol. Res. 11(3):
2012.June.15.5
DOI:
10.4238/2012.June.15.5
Cytogenomics   Research Article

Clinical retrospective analysis of cases with multiple primary malignant neoplasms

Authors: L.L. Xu and K.S. Gu

The etiological factors, clinical characteristics, diagnosis, treatment strategies, and prognosis of multiple primary malignant neoplasms (MPMNs) were investigated in order to improve its diagnosis and therapy. Clinical data of 170 patients with MPMN who were admitted to the Oncology Department of the First Affiliated Hospital of Anhui Medical University .. Read More»

Genet. Mol. Res. 13(4):