Cytogenomics
Whole-genome duplications contributed to the expansion of cytochrome b5 genes in Paramecium tetraurelia
Authors: K.J. Wu, D. Wang, J. Ding, S.H. Yang and X.H. Zhang
Cytochrome b5 (cyt b5) genes encode ubiquitous electron transport hemoproteins found in animals, plants, fungi, and purple bacteria. However, little is known about their evolutionary history in genomes so far. Here, we conducted an extensive genome-wide survey of cyt b5 genes in 20 representative model species and identified 310 of these genes. Both the a.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.9.1
- DOI:
- 10.4238/2013.January.9.1
Single-primer PCR correction: a strategy for false-positive exclusion
Authors: J. Ma, P.W. Wang, D. Yao, Y.P. Wang, W. Yan and S.C. Guan
Polymerase chain reaction (PCR) technology plays an important role in molecular biology research, but false-positive and nonspecific PCR amplification have plagued many researchers. Currently, research on the optimization of the PCR system focuses on double-primer-based PCR products. This research has shown that PCR amplificat.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr988
- DOI:
- 10.4238/vol10-1gmr988
Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis
Authors: W. Xu, S. Liu, L. Li, Z.Y. Shen and Y.L. Wu
Hepatocellular carcinoma (HCC) is one of the most lifethreatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision repair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HC.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.5
- DOI:
- 10.4238/2015.June.29.5
Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa
Authors: S.-X. Li, Q. Li, Y.-Q. Yang, L.-J. Jin, Z. Sun and S.-F. Yu
Benign lymphoadenosis of oral mucosa (BLOM) is a common oral mucosa disease and may be regarded as a precancerous lesion. However, the association between its biological behavior and lymphocyte distribution remains unclear. Therefore, to investigate the characteristics of BLOM, we studied the infiltration of lymphocytes associated with it. The expression .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.10
- DOI:
- 10.4238/2015.June.29.10
Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease
Authors: A.F. Nascimento, J.S. Oliveira2, J.C. Silva Junior and A.A.L. Barbosa
The bs mutation is responsible for the most aggressive form of sickle cell disease, has a predominantly African origin, and arrived in Brazil through the slave trade. However, the Brazilian population is highly miscegenated, underscoring the importance of ancestry-informative markers (AIMs) for the identification of the geneti.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017604
- DOI:
- 10.4238/gmr.15017604
Meta-analysis demonstrates lack of a relationship between XRCC1-399 gene polymorphisms and susceptibility to hepatocellular carcinoma
Authors: X.Y. Zeng, J.M. Huang, J.W. Xu, Y. Xu, H.P. Yu, L. Ji and X.Q. Qiu1,
XRCC1-399 allele polymorphisms have been reported to be associated with susceptibility to hepatocellular carcinoma (HCC), but the conclusions of the various studies have been inconsistent. We conducted a meta-analysis of available studies to determine whether XRCC1-399 alleles influence susceptibility to hepatocellular carcinoma. We searched English-langu.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.March.15.5
- DOI:
- 10.4238/2013.March.15.5
Polymorphisms of the angiotensin II type 1 receptor gene affect antihypertensive response to angiotensin receptor blockers in hypertensive Chinese
Authors: H.T. Gong, X.L. Ma, B.X. Chen, X.Y. Xu, Q. Li, C.X. Guo and F.H. Du
The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.21.2
- DOI:
- 10.4238/2013.June.21.2
Morphophysiological changes in Malpighian tubule cells during Myrmeleon uniformis development (Neuroptera, Myrmeleontidae)
Authors: C.A. Pacheco and T.L. Silva
The land arthropod secretory system is formed by structures called Malpighian tubules. These tubules are extremely important in insects because they maintain osmoregulation. They are located in the body cavity and are either free or inserted in the rectum wall, forming an arrangement known as the cryptonephridial system. The Malpighian tubules may have mo.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.27.1
- DOI:
- 10.4238/2013.June.27.1
Cytogenetic evaluation of tannery workers in the city of Teresina, northeastern Brazil
Authors: F.P.M. do Amaral, E.J.L.S. do Amaral, M.P.M. do Amaral, L.S. Lopes, S.I. Lemos, R.V.G. Santos, T.V.S. Chaves, M.E.A. de Moraes and M.O.A. de Moraes Filho
Assessments of chromosomal integrity and structure enable the prevention of diseases associated with the work environment, with the frequencies of chromosomal aberrations and micronuclei often being used as markers in biomonitoring. Owing to their routine manipulation of potentially toxic chemicals, tannery workers as a group merit a more thorough evaluat.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.29
- DOI:
- 10.4238/2015.December.28.29
Association of phosphodiesterase 4D gene and interleukin-6 receptor gene polymorphisms with ischemic stroke in a Chinese hypertensive population
Authors: H.J. Song, X.H. Zhou, L. Guo, F.L. Tian, X.F. Guo and Y.X. Sun
Genetic factors have been shown to be associated with the risk of stroke. However, due to individual differences, the extent of the association between genetic factors and stroke varies widely. Hypertension is considered one of the most important risk factors for stroke, but it remains unknown whether the genetic association with stroke in a hypertensive .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.50
- DOI:
- 10.4238/2015.December.29.50