Cytogenomics
Roles of functional NFKB1 and ?²-TrCP insertion/deletion polymorphisms in mRNA expression and epithelial ovarian cancer susceptibility
Authors: Z.H. Huo, H.J. Zhong, Y.S. Zhu, B. Xing and H. Tang
Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Nuclear factor-kappa B (NF-κB) is involved in carcinogenesis and in the development of EOC. The β-transducin repeat-containing protein (β-TrCP) is a positive regulator of the NF-κB signaling pathway. Recent studies have indicated that the -.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.6
- DOI:
- 10.4238/2013.March.11.6
Association of APOA1 and APOA5 polymorphisms and haplotypes with lipid parameters in a Brazilian elderly cohort
Authors: T.K. Furuya, E.S. Chen, V.K. Ota, D.R. Mazzotti, L.R. Ramos, M.S. Cendoroglo, L.Q. Araujo, R.R. Burbano and M.A.C. Smith
Apolipoproteins have an important role in lipid metabolism and transport. Polymorphisms in the APOA1/C3/A4/A5 gene cluster have been associated with lipid alterations and cardiovascular diseases. We investigated APOA1 XmnI, APOA5 S19W, and APOA5 -1131T>C polymorphisms in 377 individuals from a cohort of a longitudinal Brazilian elderly study. Allele fr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.7
- DOI:
- 10.4238/2013.February.28.7
Genetic determinants of the defense response of resistant and susceptible pepper (Capsicum annuum) cultivars infected with Phytophthora capsici (Oomycetes; Pythiaceae)
Authors: Y.-L. Zhang, D.-W. Li, Z.-H. Gong, J.-E. Wang, Y.-X. Yin and J.-J. Ji
Based on culture isolation and morphological observation blight-infected pepper plants in Shaanxi Province, China, we identified the pathogen causing pepper phytophthora blight as Phytophthora capsici. Varieties that differed in resistance (CM334, PBC602, and B27) were inoculated with this pathogen. The root activity of resistant CM334 variety was the hig.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.5
- DOI:
- 10.4238/2013.September.13.5
Meiotic pairing of B chromosomes, multiple sexual system, and Robertsonian fusion in the red brocket deer Mazama americana (Mammalia, Cervidae)
Authors: C.I. Aquino, V.V. Abril and J.M.B. Duarte
Deer species of the genus Mazama show significant inter- and intraspecific chromosomal variation due to the occurrence of rearrangements and B chromosomes. Given that carriers of aneuploidies and structural rearrangements often show anomalous chromosome pairings, we here performed a synaptonemal complex analysis to study chromosome pairing behavior in a r.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.1
- DOI:
- 10.4238/2013.September.13.1
Genetic diversity studies in pea (Pisum sativum L.) using simple sequence repeat markers
Authors: P. Kumari, N. Basal, A.K. Singh, V.P. Rai, C.P. Srivastava and P.K. Singh
The genetic diversity among 28 pea (Pisum sativum L.) genotypes was analyzed using 32 simple sequence repeat markers. A total of 44 polymorphic bands, with an average of 2.1 bands per primer, were obtained. The polymorphism information content ranged from 0.657 to 0.309 with an average of 0.493. The variation in genetic diversity among these cultivars ran.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.13.12
- DOI:
- 10.4238/2013.March.13.12
Chromosomal characteristics of a Brazilian whip spider (Amblypygi) and evolutionary relationships with other arachnid orders
Authors: E. Paula-Neto, D. Araujo, L.S. Carvalho, D.M. Cella and M.C. Schneider
We analyzed mitotic and meiotic cells of a Brazilian amblypygid, Heterophrynus longicornis, using conventional and molecular cytogenetic techniques (Giemsa staining, C-banding, Ag-NOR, and FISH with rDNA probe). This is the first study that focuses solely on amblypygid chromosomes; it was undertaken to add data on cytogenetic knowledge of this group and c.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.3
- DOI:
- 10.4238/2013.September.19.3
Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice
Authors: C.R. Silva, P.M. Vieira and L. Chen-Chen
Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as â????sofre-do-rim-quem-querâ??? and â????araticum-secoâ???, is a shrub of the Annonaceae family that grows in several regions of Brazil. Infusions of its leaves and twigs are used in folk medicine to treat rheumatism and renal colic, whe.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.2
- DOI:
- 10.4238/2013.September.19.2
Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective
Authors: Y. Huang, L. Wang, B. Bennett, R.W. Williams, Y.J. Wang, W.K. Gu and Y. Jiao
The mitochondrial ATP synthase, subunit c, isoform 3 gene (Atp5g3) encodes subunit 9, the subunit of the multisubunit enzyme that catalyzes ATP synthesis during oxidative phosphorylation in mitochondria. According to the Ensembl database, Atp5g3 in mice is located on chromosome 2 between 73746504 and 73749383 bp, within the genomic regions of two sets of .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.18.1
- DOI:
- 10.4238/2013.September.18.1
Breeding of transgenic cattle for human coagulation factor IX by a combination of lentiviral system and cloning
Authors: P.S. Monzani, J.R. Sangalli, T.H.C. De Bem, F.F. Bressan, P. Fantinato-Neto, J.R.V. Pimentel, E.H. Birgel-Junior, A.M. Fontes, D.T. Covas and F.V. Meirelles
Recombinant coagulation factor IX must be produced in mammalian cells because FIX synthesis involves translational modifications. Human cell culture-based expression of human coagulation factor IX (hFIX) is expensive, and large-scale production capacity is limited. Transgenic animals may greatly increase the yield of therapeutic proteins and reduce costs... Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.25
- DOI:
- 10.4238/2013.February.28.25
Characterization of the alkaline/neutral invertase gene in Dendrobium officinale and its relationship with polysaccharide accumulation
Authors: F. Gao, X.F. Cao, J.P. Si, Z.Y. Chen and C.L. Duan
Dendrobium officinale is one of the most well-known traditional Chinese medicines, and polysaccharide is its main active ingredient. Many studies have investigated the synthesis and accumulation mechanisms of polysaccharide, but until recently, little was known about the molecular mechanism of how polysaccharide is synthesized.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027647
- DOI:
- 10.4238/gmr.15027647