Text-mining network analysis of the response to osmotic stimuli in the intervertebral disc

Authors: X. Xu, L. Liu and Q.Y. Lu

Intervertebral disc cells experience a broad range of physical stimuli under physiologic conditions, including alterations in their osmotic environment. The purpose of this study was to construct a text-mining network of the genes induced during the response to osmotic stimuli in the intervertebral disc. We obtained a gene expression profile of human inte.. Read More»

Genet. Mol. Res. 12(2): 2013.May.13.11

DOI: 10.4238/2013.May.13.11

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Authors: S. Yan, Y.Z. Li, X.W. Zhu, C.L. Liu, P. Wang and Y.L. Liu

Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Ther.. Read More»

Genet. Mol. Res. 12(2): 2013.May.13.10

DOI: 10.4238/2013.May.13.10

Cellular responses induced in vitro by iron (Fe) in a central nervous system cell line (U343MGa)

Authors: D.D.F.A. Alc�¢ntara, H.F. Ribeiro, L.A. Matos, J.M.C. Sousa, R.R. Burbano and M.O. Bahia

Iron is the most important metallic chemical element on Earth. Poisoning caused by excessive iron in humans has been associated with pulmonary diseases including neoplasms caused by inhalation of iron oxides. The involvement of iron in neurodegenerative processes has already been described. DNA alterations are induced by iron and other chemical compounds .. Read More»

Genet. Mol. Res. 12(2): 2013.May.13.9

DOI: 10.4238/2013.May.13.9

Serotonin receptor 2C gene polymorphism associated with post-stroke depression in Chinese patients

Authors: W.K. Tang, N. Tang, C.D. Liao, H.J. Liang, V.C.T. Mok, G.S. Ungvari and K.S. Wong

The serotonin receptor 2C (HTR2C) gene has been shown to play a pivotal role in major depression. We examined the association between post-stroke depression (PSD) and polymorphism in HTR2C. A cohort of 223 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months af.. Read More»

Genet. Mol. Res. 12(2): 2013.May.13.8

DOI: 10.4238/2013.May.13.8

A phytotoxin Solanapyrone-A downregulates calcium-dependent protein kinase activity in potato

Authors: A. Hassan, N. Hatsugai and M.M. Shah

We previously demonstrated that alternaric acid, a host-specific toxin produced by the plant pathogenic fungus Alternaria solani, in the presence of Ca2+ and Mg2+, stimulated in vitro phosphorylation of His-tagged calcium-dependent protein kinase 2 from potato cultivar Rishiri (RiCDPK2). Herein, we report that Solanapyrone-A (SpA), a non-host-specific tox.. Read More»

Genet. Mol. Res. 12(2): 2013.May.13.7

DOI: 10.4238/2013.May.13.7

Evaluation of alternative schemes for recording body weights in meat-type quails by using random regression

Authors: L.P. Silva, J.C. Ribeiro, C.D.S. Leite, M.F. Sousa, C.M. Bonaf�©, G.C. Caetano, A.C. Crispim and R.A. Torres

Data from 8759 meat-type quails from the UFV1 strain and 9128 from the UFV2 strain were used to assess the possibility of reducing the number of body weight records in genetic evaluations. The evaluated animals were weighed weekly since hatching to the 6th week of life, with up to 7 records of body weight for each bird. The data were evaluated by random r.. Read More»

Genet. Mol. Res. 12(2):

Factors that influence the test day milk yield and composition

Authors: F.G. Silva, L.F. Brito, R.A. Torres, J.I. Ribeiro J�ºnior, H.R. Oliveira, G.C. Caetano and M.T. Rodrigues

The objective of this research was to study the factors that influence the test day milk yield (TDMY) and percentages of protein, fat, lactose, and total dry extract obtained on test day. We evaluated 110,732 weekly milk production records from 1496 goats and 19,271 monthly milk constituent records from 1245 Alpine and Saanen goats, which were collected f.. Read More»

Genet. Mol. Res. 12(2): 2013.13.5

DOI: 10.4238/2013.13.5

Phenotypic correction and stable expression of factor VIII in hemophilia A mice by embryonic stem cell therapy

Authors: J.J. Wang, Y. Kuang, L.L. Zhang, C.L. Shen, L. Wang, S.Y. Lu, X.B. Lu, J. Fei, M.M. Gu and Z.G. Wang

Hereditary deficiency of factor VIII (FVIII) leads to hemophilia A, a severe X-linked bleeding disorder. Current therapies include fixed-dose FVIII prophylaxis, factor replacement therapy, and most recently, gene therapy. Prophylaxis and FVIII replacement therapies are limited by incomplete efficacy, high cost, restricted availability, and development of .. Read More»

Genet. Mol. Res. 12(2): 2013.May.13.4

DOI: 10.4238/2013.May.13.4