Medical Genetics
Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer
Authors: M. Qi, D.M. Liu, L.L. Pan and Y.X. Lin
Numerous studies have evaluated the association between the human interleukin-10 gene -592C>A polymorphism and gastric cancer risk. However, the results have been inconsistent. This meta-analysis was designed to resolve these controversies. Systematic searches of the electronic databases Embase, PubMed, and Google Scholar were performed to identify rel.. Read More»
- Genet. Mol. Res. 13(4):
Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma
Authors: C.R. Tanyel1, Z.B. Cincin2, B. Gokcen-Rohlig1, K. Bektas-Kayhan3, M. Unur3 and B. Cakmakoglu2
We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restric.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.20
- DOI:
- 10.4238/2013.November.18.20
Comparison of computed tomography and magnetic resonance imaging in the evaluation of facet tropism and facet arthrosis in degenerative cervical spondylolisthesis
Authors: C. Xu, Z.H. Ding and Y.K. Xu
The aim of this study was to determine the reliability of magnetic resonance imaging (MRI) in the assessment of facet tropism and facet arthrosis of spondylolisthesis levels in degenerative cervical spondylolisthesis as compared to computed tomography (CT). The discrepancies in the interpretation of CT and MRI data in the eval.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.5
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.5
Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk
Authors: J.J. Hu1*, Z.T. Wang 2* and B. Li1
Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Ty.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.15.2
- DOI:
- 10.4238/2013.October.15.2
Genetic divergence among accessions of melon from traditional agriculture of the Brazilian Northeast
Authors: F.A.S. Arag�£o, J. Torres Filho, G.H.S. Nunes, M.A. Queir�³z, P.N. Bordallo, G.S.C. Buso, M.A. Ferreira, Z.P. Costa and F. Bezerra Neto
The genetic divergence of 38 melon accessions from traditional agriculture of the Brazilian Northeast and three commercial hybrids were evaluated using fruit descriptors and microsatellite markers. The melon germplasm belongs to the botanic varieties cantalupensis (19), momordica (7), conomon (4), and inodorus (3), and to eight genotypes that were identif.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.6.3
- DOI:
- 10.4238/2013.December.6.3
Relationship between renal injury and the antagonistic roles of angiotensin-converting enzyme (ACE) and ACE2
Authors: C. Ma, H. Xin, X.-Y. Jiang, Y.-X. Wang and Y.-S. Zhang
Angiotensin-converting enzyme 2 (ACE2), a newly discovered carboxypeptidase in the renin-angiotensin system (RAS), antagonizes ACE activity and plays an active role during tissue injury. Yet the mechanism of its action is not well known. Using a streptozotocin (STZ)-induced renal injury rat model, we investigated the relations.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.5
- DOI:
- 10.4238/2014.April.3.5
Quality trait variations in [60Co]-irradiated wheat and high-molecular-weight glutenin subunit mutant identification
Authors: D.-E. Lai1, M. Wang1 and C.-Y. Zhang2
With 300 Gy of [60Co] γ-ray radiation of dry wheat seeds of Vortex 9722, the protein content, wet gluten content, sedimentation value, and hardness variation were analyzed in 341 lines in M4. Using over population mean ± 2X standard deviation as the screening standard, 8 lines with higher protein and wet gluten content and 4 lines with lower .. Read More»
- Genet. Mol. Res. 13(4):
Effectiveness of olfactory ensheathing cell transplantation for treatment of spinal cord injury
Authors: Y.J .Rao, W.X. Zhu, Z.Q. Du, C.X. Jia, T.X. Du, Q.A. Zhao, X.Y. Cao and Y.J. Wang
The aim of this study was to determine the effectiveness and safety of transplantation of olfactory ensheathing cells for functional repair of the spinal cord. An olfactory bulb was obtained from a 4- to 5-month-old aborted fetus, and it was digested into single olfactory ensheathing cells and then cultured and purified for 1 .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.7
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.7
Comparative genetic diversity of wild and hatchery-produced populations of tongue sole (Cynoglossus semilaevis) using multiplex PCR assays with polymorphic microsatellite markers
Authors: H.S. An, E.-M. Kim, H.W. Kang, H.S. Han, J.W. Lee, J.Y. Park,J.I. Myeong and C.M. An
The tongue sole, Cynoglossus semilaevis (Cynoglossidae), is one of the most economically important fishery resources in Korea. This study presents a preliminary investigation of the future viability of the complete aquaculture of tongue sole in Korea. Specifically, possible differences in genetic variability between wild populations of tongue sole from Ko.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.20
- DOI:
- 10.4238/2013.December.4.20
Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer
Authors: J. Jin, L. Xie, C.H. Xie and Y.F. Zhou
We aimed to explore the association between aberrant DNA methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) genes with gastric cancer. A total of 283 gastric cancer patients who were confirmed by pathological diagnosis were included in our study. Aberrant DNA methylation of MGMT.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.9
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.9