Medical Genetics
Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population
Authors: W. Wei, M. Jiang, L. Luo, Z. Li, P. Wang and W.Q. Dong
Recent genome wide association studies (GWAS) and candidate gene studies have revealed many novel loci associated with colorectal cancer susceptibility. We evaluated the effect of these colorectal cancer-associated variants on the risk of breast cancer in a Chinese Han population. Seven single nucleotide polymorphisms (SNPs) (rs3856806 in PPARG, rs7014346.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.14
- DOI:
- 10.4238/2013.December.4.14
Interleukin-1�² +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis
Authors: F.-L. Wu, L.-Y. Wang, Y.-Q Huang, W.-B. Guo, C.-D. Liu and S.-G. Li
The purpose of this meta-analysis was to determine whether genetic variants of the interleukin-1β[+3954 C>T (rs1143634)] (IL-1β +3954 C>T) gene polymorphisms were associated with orthodontic external apical root resorption (EARR). A meta-analysis was carried out using data entered into the PubMed and Embase electronic databases before Octo.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.6
- DOI:
- 10.4238/2013.October.18.6
Genetic diversity of Cosmos species revealed by RAPD and ISSR markers
Authors: A. RodrÃ?Âguez-Bernal, J.L. PiÃ?±a-Escutia, L.M. VÃ?¡zquez-GarcÃ?Âa and A.M. Arzate-FernÃ?¡ndez
The genus Cosmos is native of America and is constituted by 34 species; 28 of them are endemic of Mexico. The cosmos are used as a nematicide, antimalarial, and antioxidative agent. The aim of this study was to estimate the genetic diversity among 7 cosmos species based on random amplified polymorphic DNA (RAPD) and inter-simple sequences repeats (ISSR) m.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.13
- DOI:
- 10.4238/2013.December.4.13
Evidence for inbreeding depression in the tree Robinia pseudoacacia L. (Fabaceae)
Authors: C.Q. Yuan, Y.F. Li, L. Wang, K.Q. Zhao, R.Y. Hu, P. Sun, Y.H. Sun, Y. Li, W.X. Gu and Z.Y. Zhou
The magnitude of inbreeding depression within populations is important for the evolution and maintenance of mixed mating systems. However, data are sparse on the magnitude of inbreeding depression in Robinia pseudoacacia. In this study, we compared differences in the mature seed set per fruit, seed mass, germination success, and seedling growth between se.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.12
- DOI:
- 10.4238/2013.December.4.12
Aberrant gene expression profiles in hepatocellular carcinoma detected by microdissection
Authors: Y.M. Wei1, Y.Y. Li2, Y.C. Zhang2 and Y.Q. Nie2
The aim of this study was to identify genomic aberrations in hepatocellular carcinoma (HCC) by using laser capture microdissection (LCM) combined with microarray analysis. Samples were procured by LCM from HCC and patient-matched normal liver tissue surgically resected from 4 patients. RNA was isolated from the samples and reverse transcribed into cDNA. A.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.3
- DOI:
- 10.4238/2013.November.18.3
Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer
Authors: J.M. He, Y.D. Pu, Y.J. Wu, R. Qin, Q.J. Zhang, Y.S. Sun, W.W. Zheng and L.P. Chen
We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vita.. Read More»
- Genet. Mol. Res. 13(4):
Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population
Authors: G.L. Hong, X.Z. Chen, Y. Liu, Y.H. Liu, X. Fu, S.B. Lin and Q. Zhu
Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susc.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.9
- DOI:
- 10.4238/2013.December.4.9
Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment
Authors: J. Song, L.Z. Wang, X. Li, T.P. Jiang, T.Z. An, M. Xu, X.P. Wu and S. Zhou
We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). In total, 156 patients with histologically confirmed HCC within 2 months were collected from January 2007 to January 2008. The ge.. Read More»
- Genet. Mol. Res. 13(4):
Cytotoxic and mutagenic effects of iodine-131 and radioprotection of acerola (Malpighia glabra L.) and beta-carotene in vitro
Authors: I.V. Almeida, E. D�¼sman, M.C. Heck, J.A. Pamphile, N.B. Lopes, L.T.D. Tonin and V.E.P. Vicentini
The radioisotope iodine-131 [131I] can damage DNA. One way to prevent this is to increase the amount of antioxidants via dietary consumption. The goal of this study was to evaluate the radioprotective effect of fresh acerola pulp and synthetic beta-carotene in Rattus norvegicus hepatoma cells (HTC) in response to [131I] exposure in vitro. Cellular DNA dam.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.10.1
- DOI:
- 10.4238/2013.December.10.1
Fas/FasL in the immune pathogenesis of severe aplastic anemia
Authors: C.Y. Liu, R. Fu, H.Q. Wang, L.J. Li, H. Liu, J. Guan, T. Wang, W.W. Qi, E.B. Ruan, W. Qu, G.J. Wang, H. Liu, Y.H. Wu, J. Song, L.M. Xing and Z.H. Shao
Fas/FasL protein expression of bone marrow hematopoietic cells was investigated in severe aplastic anemia (SAA) patients. Fas expression was evaluated in CD34+, GlycoA+, CD33+, and CD14+ cells labeled with monoclonal antibodies in newly diagnosed and remission SAA patients along with normal controls. FasL expression was evalua.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.3
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.3