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Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population

Author(s): G.L. Hong, X.Z. Chen, Y. Liu, Y.H. Liu, X. Fu, S.B. Lin and Q. Zhu

Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of hypertension in a Chinese Han population. A hospital-based case-control study in a Chinese Han population was carried out, including 500 hypertension patients and 506 healthy controls. The five SNP markers were detected using the Sequenom MassArray® iPLEX System.