Medical Genetics
Analysis of the haplotype and linkage disequilibrium of PPAR�³ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province...
Authors: S.X. Guo, H. Guo, R.L. Ma, Y.S. Ding, J.Y. Zhang, J.M. Liu, M. Zhang, Q. Niu, N. Qiang, S.G. Li and C.N. Qi
We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS.. Read More»
- Genet. Mol. Res. 13(4):
Analysis of protein-protein interaction network in chronic obstructive pulmonary disease
Authors: Y.P. Yuan, Y.H. Shi and W.C. Gu
Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality throughout the world. The purpose of our study was to uncover biomarkers and explore its pathogenic mechanisms at the molecular level. The gene expression profiles of COPD samples and normal controls were downloaded from Gene Expression Omnibus. Matlab was used for .. Read More»
- Genet. Mol. Res. 13(4):
Effects of metallothionein-3 and metallothionein-1E gene transfection on proliferation, cell cycle, and apoptosis of esophageal cancer cells
Authors: Z.Q. Tian, Y.Z. Xu, Y.F. Zhang, G.F. Ma, M. He and G.-Y. Wang
Metallothionein (MT)-3 has cell growth inhibitory activity, and is the only currently known MT subtype with unique physiological functions. The expression levels of MT-1E, a subtype of MT-1, were positively correlated with the degree of esophageal cancer malignancy. The present study aimed to investigate the effects of MT-3 and MT-1E gene transfection on .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.17.2
- DOI:
- 10.4238/2013.October.17.2
Analysis of the haplotype and linkage disequilibrium of PPAR�³ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province
Authors: S.X. Guo, H. Guo, R.L. Ma, Y.S. Ding, J.Y. Zhang, J.M. Liu, M. Zhang, Q. Niu, N. Qiang, S.G. Li and C.N. Qi
We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS.. Read More»
- Genet. Mol. Res. 13(4):
Decreased expression of PIAS1 and PIAS3 in essential thrombocythemia patients
Authors: H.-H. Hsiao1,2, Y.-C. Liu1,2, M.-Y. Yang3, Y.-F. Tsai2, T.-C. Liu1,2, C.-S. Chang1,2 and S.-F. Lin1,2
Gain of function mutation of Janus kinase 2 (JAK2V617F) has been identified in Philadelphia-negative myeloproliferative diseases; about half of essential thrombocythemia (ET) patients harbor this mutation. The activated JAK-STAT pathway promotes cell proliferation, differentiation and anti-apoptosis. We studied the role of negative regulators of the JAK-S.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.10
- DOI:
- 10.4238/2013.November.18.10
Using PCR-RFLP for sexing of the endangered Gal�¡pagos petrel (Pterodroma phaeopygia)
Authors: L. PatiÃ?±o, M. Cruz, P. MartÃ?Ânez and V. CedeÃ?±o-Escobar
Pterodroma phaeopygia is a critically endangered avian species of the Galápagos Islands. This bird is sexually monomorphic, making it difficult to identify the sex. This information, however, is relevant to studies of behavior, ecology, and management of wild or captive populations. Here, we aimed to implement a molecular approach for determining s.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.13
- DOI:
- 10.4238/2013.October.18.13
Overexpression, purification, and pharmacologic evaluation of anticancer activity of ribosomal protein L24 from the giant panda (Ailuropoda melanoleuca)
Authors: Y.L. Hou, X. Ding, W. Hou, B. Song, T. Wang, F. Wang, J. Li, J. Zhong, T. Xu, B.X. Ma, H.Q. Zhu, J.H. Li and J.C. Zhong
The ribosomal protein L24 (RPL24) belongs to the L24E family of ribosomal proteins and is located in the cytoplasm. The purpose of this study was to investigate the structure and anti-cancer function of RPL24 of the giant panda (Ailuropoda melanoleuca). The complementary DNA of RPL24 was cloned successfully using reverse transcription-polymerase chain rea.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.11
- DOI:
- 10.4238/2013.October.18.11
Development and characterization of new microsatellites for walnut (Juglans regia)
Authors: Z.Y. Zhang, J.W. Han, Q. Jin, Y. Wang, X.M. Pang and Y.Y. Li
The expressed sequence tag (EST) database represents a potentially valuable resource for the development of simple sequence repeat (SSR) markers for use in evolutionary studies. EST-SSRs reveal polymorphisms not only within the source taxon, but in related taxa as well. In this paper, we describe a case study in which the publicly available walnut (Juglan.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.10
- DOI:
- 10.4238/2013.October.18.10
Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer
Authors: Y. Han, D.P. Yu, S.J. Zhou, X.Y. Song, Y.S. Li, N. Xiao, Z.D. Liu, X.J. Sun, Q.Y. Zhao and S.K. Liu.
More than 40 oncogenes associated with non-small cell lung cancer (NSCLC) have been identified with varied gene expression. The correlations between specific clinical characteristics and oncogene expression in NSCLC patients were examined. From October 2011 to September 2012, a total of 60 patients with NSCLC (male:female, 34:24; mean age, 59.5 ± 1.. Read More»
- Genet. Mol. Res. 13(4):
N-terminal functional region of the invariant chain efficiently targets the binding of a CTL epitope to MHC class I molecules during cross-presentation
Authors: C. Wu, D.G. Zhang, F.F. Chen, X.L. Liu, S.J. Liu and W.Y. Yu
Cross-presentation (CP) is important for priming T cell responses to many viral, bacterial, and tumor antigens. Here, we designed two Ii mutants, based on evidence that the invariant chain (Ii, also named CD74) binds newly synthesized MHC class I molecules with the class II-associated invariant chain peptide (CLIP) region of I.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.16
- DOI:
- 10.4238/2014.April.3.16