Medical Genetics
Polymorphism of SREBP1 is associated with beef fatty acid composition in Simmental bulls
Authors: L. Xu*, L.P. Zhang*, Z.R. Yuan, L.P. Guo, M. Zhu, X. Gao, H.J. Gao, J.Y. Li and S.Z. Xu
The sterol regulatory element binding factor 1 gene (SREBP1) plays an important role in the biosynthesis of fatty acids and cholesterol, and in lipid metabolism. The objective of this study was to investigate the effect of genetic polymorphisms of SREBP1 on the fatty acid composition of muscle and carcass traits in Simmental bulls and Snow Dragon black ca.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.7
- DOI:
- 10.4238/2013.November.22.7
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility
Authors: L.P. Ren, Y.S. Xian, D.M. Diao, Y. Chen, Q. Guo and C.X. Dang
BRCA1-interacting protein C-terminal helicase 1 (BRIP1) is a DNA helicase that influences the DNA repair ability and tumor suppressor function of BRCA1. Truncating BRIP1 mutations have been described as cancer susceptibility alleles. To evaluate BRIP1 polymorphisms as risk factors for breast cancer, we performed a detailed analysis of possible single nucl.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.6
- DOI:
- 10.4238/2013.November.22.6
Gene expression during induced differentiation of sheep bone marrow mesenchymal stem cells into osteoblasts
Authors: Y. Hu, X.-X. Tang and H.-Y. He
The aim of this study was to observe the dynamic expression of osteopontin, type I collagen, and osteocalcin genes during the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts and confirm whether BMSCs can differentiate and mature into osteoblasts. A healthy, 2-month-old Altay tailed sheep was obtained, and 10 mL bone marrow was .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.4
- DOI:
- 10.4238/2013.December.11.4
A new tetra-primer ARMS-PCR for genotyping bovine kappa-casein polymorphisms
Authors: P.A.S. Fonseca, I.C. Rosse, M. DeMiranda, M.A. Machado,R.S. Verneque, M.G.C.D. Peixoto and M.R.S. Carvalho
Kappa-casein (κ-casein) is one of the most abundant milk proteins. Its main function is to avoid the aggregation of casein micelles, keeping them, and therefore calcium phosphate, in pockets in solution. In bovines, a κ-casein functional polymorphism has been associated with fat, calcium, and protein milk contents and faster curd contraction i.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.3
- DOI:
- 10.4238/2013.December.11.3
Evaluation of genetic diversity in Chinese kale (Brassica oleracea L. var. alboglabra Bailey) by using rapid amplified polymorphic DNA and sequence-related amplified polymorphism markers
Authors: J. Zhang and L.G. Zhang1
Chinese kale is an original Chinese vegetable of the Cruciferae family. To select suitable parents for hybrid breeding, we thoroughly analyzed the genetic diversity of Chinese kale. Random amplified polymorphic DNA (RAPD) and sequence-related amplified polymorphism (SRAP) molecular markers were used to evaluate the genetic div.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.10
- DOI:
- 10.4238/2014.February.14.10
Study of the correlation between growth hormone deficiency and serum leptin, adiponectin, and visfatin levels in adults
Authors: Z.-P. Li, M. Zhang, J. Gao, G.-Y. Zhou, S.-Q. Li and Z.-M. An
We aimed to determine the significance and changes in leptin, adiponectin (ADP), and visfatin levels in adults with growth hormone deficiency (GHD). Forty adults (19 men, 21 women) who had been diagnosed with GHD comprised the observation group, while 36 healthy adults (18 men, 18 women) were used as the control group. Fasting venous blood was collected t.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.16
- DOI:
- 10.4238/2014.February.14.16
Hydrogen peroxide enhances the uptake of polyethylenimine/oligonucleotide complexes in A549 cells by activating CaMKII independent of [Ca2+]c elevation
Authors: Z. Ma, W.W. Sun and X. Wang
Aerosol oligonucleotide therapy has vast potential in pulmonary system diseases. Reactive oxygen species (ROS) play an important role in complex physiological processes such as cell signaling, apoptosis, etc. Therefore, to determine the mechanism of ROS involvement in polyethylenimine/oligonucleotide (PEI/ON) endocytosis in ce.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.21.15
- DOI:
- 10.4238/2014.February.21.15
Histochemical map of the ectopic expression of the Arabidopsis at Ext1 extensin gene in transgenic tobacco
Authors: G. Merkouropoulos and A.H. Shirsat
Histochemical analysis of transgenic tobacco plants harboring the promoter of the Arabidopsis extensin gene atExt1 fused to the β-glucuronidase gene coding sequence demonstrated expression of the transgene in stem tissues. The transgene was expressed in cells of the internal and external phloem at the nodal and internodal.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.19.3
- DOI:
- 10.4238/2012.July.19.3
In silico modeling of the Moniliophthora perniciosa Atg8 protein
Authors: A.C.F. Pereira, T.H.S. Cardoso, M. Brendel and C. Pungartnik
Autophagy is defined as an intracellular system of lysosomal degradation in eukaryotic cells, and the genes involved in this process are conserved from yeast to humans. Among these genes, ATG8 encodes a ubiquitin-like protein that is conjugated to a phosphatidylethanolamine (PE) membrane by the ubiquitination system. The Atg8p-PE complex is important in i.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.13
- DOI:
- 10.4238/2013.December.11.13
Genome-wide identification, characterization, and expression analysis of the MLO gene family in Cucumis sativus
Authors: S.J. Zhou, Z. Jing and J.L. Shi
Mildew resistance locus o (MLO) is a plant-specific seven-transmembrane (TM) gene family. Several studies have revealed that certain members of the MLO gene family mediate powdery mildew susceptibility in three plant species, namely, Arabidopsis, barley, and tomato. The sequenced cucumber genome provides an opportunity to conduct a comprehensive overview .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.8
- DOI:
- 10.4238/2013.December.11.8