Medical Genetics
Application and effects of mouse Foxp3 antibody and fixation/permeabilization buffer on the detection of CD4+ regulatory T cells in various mammal species
Authors: Y.L. Sun, G.G. Lin, K. Zhang, L.N. Wang and J.M. Li
CD4+ regulatory T lymphocytes (Treg cells) play a crucial role in maintaining the normal immune homeostasis. Foxp3, as a key marker for Treg cells, is widely used to identify Treg cells, not only in humans but also in other species, like mouse, porcine, ovine, and bovine. To detect reproducible Treg cells is important for evaluating the state of the immun.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.5
- DOI:
- 10.4238/2013.December.11.5
Polymorphism in PGLYRP-2 gene by PCR-RFLP and its association with somatic cell score and percentage of fat in Chinese Holstein
Authors: H.L. Wang, Z.X. Li, L. Chen, J. Yang, L.J. Wang, H. He, F.B. Niu, Y. Liu, J.Z. Guo and X.L. Liu
Peptidoglycan recognition protein 2 (PGLYRP-2), which belongs to the PGRP family, is the only member that has no direct bactericidal activity but has N-acetylmuramoyl-l-alanine amidase activity. This feature of PGLYRP-2 indicates that it may play an important role in eliminating the pathogen associated molecular pattern (PAMP), such as peptidoglycan (PGN).. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.13.7
- DOI:
- 10.4238/2013.December.13.7
High resolution computed tomography and classification of children with interstitial lung diseases
Authors: M.L. He, H. Lai, Y. Cao, Y.Z. Shuai and S.C. Yu
High resolution computed tomography (HRCT) was used to classify children with interstitial lung diseases (ILD). Sixty children with ILD underwent HRCT in supine position under free-respiratory conditions during scanning. Children under 5 years old were sedated with chloral hydrate and the scanning scope was from the lung apex .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.9
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.9
Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome
Authors: X.H. Wang, S.Q. Liu, Y.L. Wang and Y. Jin
Serum high-sensitivity C-reactive protein (hs-CRP) is a sensitive indicator of inflammation, which is closely related with the progress of plaque formation. Interleukin-6 (IL-6) is one of the inflammatory markers of local coronary plaque and the peripheral blood cycle, promoting the occurrence of atherosclerosis development an.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.11
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.11
Association of the CD36 gene with impaired glucose tolerance, impaired fasting glucose, type-2 diabetes, and lipid metabolism in essential hypertensive patients
Authors: Y. Wang, X.O. Zhou, Y. Zhang, P.J. Gao and D.L. Zhu
Essential hypertension is a common disorder that can increase the risk of type 2 diabetes (T2D). CD36 has been studied in patients with diabetes and hypertension extensively; however, few studies have focused on the relationship of the CD36 gene with impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) or T2D in essential hypertension patients... Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.10.2
- DOI:
- 10.4238/2012.July.10.2
Selection of peptides for serological detection of equine infectious anemia
Authors: E.M. Santos, R. Cardoso, G.R.L. Souza, L.R. Goulart, M.B. Heinemann, R.C. Leite and J.K.P. Reis
Equine infectious anemia caused by equine infectious anemia virus is an important disease due to its high severity and incidence in animals. We used a phage display library to isolate peptides that can be considered potential markers for equine infectious anemia diagnosis. We selected peptides using IgG purified from a pool comprised of 20 sera from anima.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.24.2
- DOI:
- 10.4238/2012.May.24.2
KDR gene silencing inhibits proliferation of A549cells and enhancestheir sensitivity to docetaxel
Authors: R. Wei and J.-P. Zang
We investigated the effects of kinase-domain insert containing receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to docetaxel. After designing and synthesizing the KDR siRNA sequence, the sequence was transfected into A549 cells using Lipofectamine 2000. The expression of KDR.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.43
- DOI:
- 10.4238/2015.November.18.43
Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis
Authors: M. Li, J.Y. Liang, Z.H. Sun, H. Zhang and Z.R. Yao
Congenital insensitivity to pain with anhidrosis (CIPA; MIM 256800) is a rare autosomal recessive disorder characterized by absence of reaction to noxious stimuli, recurrent episodes of fever, anhidrosis, and mental retardation. It is caused by mutations in the gene coding for neurotrophic tyrosine kinase receptor type 1 (NTRK1; MIM# 191315). We screened .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.8
- DOI:
- 10.4238/2012.May.18.8
Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico
Authors: E. Flores-Alfaro, G. FernÃ?¡ndez-Tilapa, E. Salazar-MartÃ?Ânez, M. Cruz, B. Illades-Aguiar and I. Parra-Rojas
Variants in the C-reactive protein (CRP) gene have been found to be associated with various phenotypic traits. We evaluated the effect of four SNPs in the CRP gene on serum levels of protein and body mass index (BMI) in 150 unrelated Mexican subjects from 18 to 25 years old, without hypertension, non-overweight, and without inflammatory diseases, non-smok.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.14.5
- DOI:
- 10.4238/2012.May.14.5
Intra-aortic balloon pump treatment for patients with acute anterior wall myocardial infarction after reperfusion therapy
Authors: C.G. Feng, X.J. Yang, Q. Fu, Y.J. Wang, H.Y. Ruan, Y. Lu, X.L. Li and X.P. Zhang
We evaluated the effects of an intra-aortic balloon pump on hemodynamics, brain natriuretic peptide concentration and cardiac function of patients with acute myocardial infarction, after reperfusion therapy. Sixty-three patients with acute anterior wall ST-elevation myocardial infarction who underwent primary percutaneous coro.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.14
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.14