Hypertension
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Authors: R.S. Mascarenhas, F.R.B. Oliveira, J.F. Corr�?ªa, K.S.F. e Silva, I.R. Costa, A.M. Barbosa, M.H. Lagares, F.L. Campedelli, M.P. de Morais, J.V.M. Martins, D.A. Rodrigues, e K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039836
- DOI:
- 10.4238/gmr16039836
AluYb8 insertion in the WNK1 gene is not associated with hypertension in a Russian Caucasian population
Authors: Elmira Akhmedova, Svetlana Y. Nikulina, Alla B. Salmina, Anna Chernova, Marina Bazanova, Anna Ohapkina, Aleksey Semenchukov, Paolo E. Maltese, Elena Manara and Matteo Bertelli
WNK1 (With No-lysine Kinase 1), a serine-threonine kinase, regulates blood pressure by acting on various sodium transport-related ion channels. Several studies report a link between common variants of the WNK1 gene and hypertension. No data exists on Russian populations. Our aim was to evaluate the association between the WNK1.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039809
- DOI:
- 10.4238/gmr16039809
Association of CYP2C19*2 with hyperlipidemia in patients with the wild-type CYP2C9
Authors: K. Khalighi, G. Cheng, S. Mirabbasi, B. Khalighi, Y. Wu and W. Fan
Arachidonic acids are metabolized by cytochromes P450 (CYP450) to epoxyeicosatrienoic acids (EETs). EETs have many cardiovascular protective effects such as vasodilation, anti-hypertension, anti-inflammation, lipid-lowering effects, and favorable effects on glucose homeostasis. This study aimed to investigate whether gene poly.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039737
- DOI:
- 10.4238/gmr16039737
Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population
Authors: Z. Fang, M. Li, Z. Ma and G. Tu
Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, t.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16037446
- DOI:
- 10.4238/gmr16037446
Correlation between the NPPB gene promoter c.-1298 G/T polymorphism site and pulse pressure in the Chinese Han population
Authors: K. Zeng, X.D. Wu, H.D. Cai, Y.G. Gao, G. Li , Q.C. Liu, F. Gao, J.H. Chen and C.Z. Lin
The aim of this study was to investigate the correlation between the natriuretic peptide precursor B (NPPB) gene single nucleotide polymorphism (SNP) c.-1298 G/T and pulse pressure (PP) of the Chinese Han population and the association between genotype and clinical indicators of hypertension. Peripheral blood was collected fro.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.4
- DOI:
- 10.4238/2014.April.29.4
Risk factors for the development of essential hypertension in a Mongolian population of China: a case-control study
Authors: N. Dalai, H. Cui, M. Yan, G. Rile, S. Li and X. Su
Lifestyle, habits, diet, and genetics are all important factors associated with the prevalence of hypertension. Many association studies have been performed in the Chinese Han population, whereas data explaining the high prevalence of hypertension in the Mongolian population remain scarce. In the present study, we aimed to det.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.6
- DOI:
- 10.4238/2014.April.29.6
Association of beta 2 adrenoceptor gene polymorphisms in Malaysian hypertensive subjects
Authors: M. Komara, R. Vasudevan, P. Ismail, S.A. Bakar, S.R. Pishva and F. Heidari
The sympathetic nervous system plays a major role in blood pressure regulation. Beta 2 (β2) adrenoceptor gene polymorphisms have been associated with hypertension in different populations with conflicting results. We examined the association of three common polymorphisms, Arg16Gly, Gln27Glu, and Thr164Ile, of the β2 .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.16.2
- DOI:
- 10.4238/2014.April.16.2
Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population
Authors: G.L. Hong, X.Z. Chen, Y. Liu, Y.H. Liu, X. Fu, S.B. Lin and Q. Zhu
Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susc.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.9
- DOI:
- 10.4238/2013.December.4.9
Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients
Authors: L. Han1,2, X.J. Xu1,2, X.H. Liang1,2 and J. Ma1,2
We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essentia.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.30.2
- DOI:
- 10.4238/2013.October.30.2
Significant association between lower pulse pressure and increasing levels of a novel type of phospholipid
Authors: C.S. Yao, Q.Z. Wu, H.X. Xu, F. Liu, L.G. Chang, L.C. Song, L.S. Gao and X.L. Meng
The aim of this study was to analyze the association between pulse pressure and a novel type of phospholipid with solubility similar to that of lysophosphatidic acid (LPA), designated as AP, which was reported to be elevated during ischemia. In this cross-sectional study, 416 hypertensive patients and 252 controls aged between.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.21.16
- DOI:
- 10.4238/2014.February.21.16