Hypertension
Personalized diagnosis by cached solutions with hypertension as a study model
Authors: P.C. Carvalho, S.S. Freitas, A.B. Lima, M. Barros, I. Bittencourt, W. Degrave, I. Cordovil, R. Fonseca, M.G.C. Carvalho, R.S. Moura Neto and P.H. Cabello
Statistical modeling of links between genetic profiles with environmental and clinical data to aid in medical diagnosis is a challenge. Here, we present a computational approach for rapidly selecting important clinical data to assist in medical decisions based on personalized genetic profiles. What could take hours or days of .. Read More»
- Genet. Mol. Res. 5(4):
Association between G-217A polymorphism in the AGT gene and essential hypertension: a meta-analysis
Authors: R. Yao, Y.Y. Du, Y.Z. Zhang, Q.H. Chen, L.S. Zhao and L. Li
Numerous studies have evaluated the association between the angiotensinogen ( AGT ) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature sea.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.4
- DOI:
- 10.4238/2015.May.25.4
Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese
Authors: H.G. Wang, J.L. Wang, P. Chang, F.L. Cao4, X.C. Liu, Y.B. Ma, G.X. Zhai and H.Q. Gao
We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr946
- DOI:
- 10.4238/vol9-3gmr946
Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese womenc
Authors: H. Lin, Z. Yin, X.Y. Yu, N. Lin, Y. Lin, J. Chen, Y.Z. Chen, K.P. Lu and H.K. Liu
We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) w.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.28
- DOI:
- 10.4238/2014.August.7.28
Immune protective mechanism of rMOMP protein ophthalmic vaccine regarding intraocular hypertension and retinal optic nerve injury in rats
Authors: X.Y. Xin, F.Y. Sun and L.L. Gao
The aim of this study was to explore the immune protective mechanism of rMOMP protein vaccine in intraocular hypertension and retinal optic nerve injury in rats. The rMOMP protein ophthalmic vaccine was prepared and quality-controlled. Sixty normal adult SD rats were randomly divided into two groups to establish a chronic ocular hypertension model and an .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.5
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.5
Correlation between MTHFR gene methylation and pre-eclampsia, and its clinical significance
Authors: J. Ge, J. Wang, F. Zhang, B. Diao, Z.F. Song, L.L. Shan, W. Wang, H.J. Cao and X.Q. Li
We investigated the correlation between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene methylation and pre-eclampsia, and its clinical significance, by comparing methylation in the MTHFR gene promoter of the placenta and peripheral venous blood in pre-eclampsia and normal gravidas. We enrolled 259 gravidas from the People’s Liberation Army 20.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.10
- DOI:
- 10.4238/2015.July.17.10
Expression of STK39 in peripheral blood of hypertension patients and the relationship between its genetic polymorphism and blood pressure
Authors: B. Li, M. Yang and J.W. Liu
This study investigated the STK39 expression in peripheral blood of hypertension patients and the relation between its genetic polymorphism and blood pressure. The observation group comprised of 42 primary hypertension patients admitted to our hospital, and the control group comprised of 30 healthy individuals who underwent physical examination in our hos.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Fluorescence in situ hybridization analysis with subtelomere specific probes (12pter-15qter) showed no differences in deletion patterns between normotensive and essential hypertension
Authors: S.T. Onrat and A.G. Tomat�±r
Telomere biology is intimately linked to the genetic/environmental etiology of cardiovascular and metabolic diseases and telomere shortening is emerging as an important biomarker disease. The relationship between subtelomeric deletions and genetic hypertension was examined. Fluorescence in situ hybridization was used to direct.. Read More»
- Genet. Mol. Res. 7(3):
- vol7-3gmr464
- DOI:
- 10.4238/vol7-3gmr464
Correlation of VCAM-1 expression in serum, cord blood, and placental tissue with gestational hypertension associated with fetal growth restriction in women from Xingtai Hebei, China
Authors: H.G. Zhang, W. Guo, H.F. Gu, S.B. Chen, J.Q. Wang, Z.X. Qiao, H.S. Ma and S.X. Geng
The aim of this study was to investigate the expression of vascular adhesion molecule (VCAM)-1 in the maternal serum, cord blood, and placental tissue of pregnant women from Xingtai, Hebei, with gestational hypertension (GH) combined with fetal growth restriction (FGR). A total of 108 patients with GH combined with FGR (GH-FGR), 60 patients with GH alone .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038274
- DOI:
- 10.4238/gmr.15038274
Association of eNOS gene polymorphisms with essential hypertension in the Han population in southwestern China
Authors: J. Li, Y. Cun, W.R. Tang, Y. Wang, S.N. Li, H.R. Ouyang, Y.R. Wu, H.J. Yu and C.J. Xiao
Endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. Polymorphisms in the eNOS gene have been found to be associated with hypertension in different human populations, including Northern and Southern Chinese Han populations. To examine the relationshi.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1160
- DOI:
- 10.4238/vol10-3gmr1160