Hypertension
Hypertension-mediated enhancement of JNK activation in association with endoplasmic reticulum stress in rat model hippocampus with cerebral ischemia-reperfusion
Authors: Y.N. Zhao, J.M. Li, C.X. Chen, P. Zhang and S.X. Li
Acute brain ischemia can induce the activation of c-Jun N-terminal kinases (JNKs). Hypertension is a critical etiology for brain ischemia. We identified the effects of hypertension on the activation of JNK as well as its impact on SP600125, a JNK inhibitor, during endoplasmic reticulum stress (ERS) in the hippocampus using a rat model. Transient whole-brain .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.10
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.10
Serum levels of high-sensitivity troponin T: a novel marker for left ventricular remodeling and performance in hypertensive subjects
Authors: D.M. Miao, L.P. Zhang*, H.P. Yu*, J.Y. Zhang, W.K. Xiao and P. Ye
It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.7
- DOI:
- 10.4238/2014.July.7.7
G501C polymorphism of the oxidized LDL receptor gene is associated with albuminuria in Chinese essential hypertension patients
Authors: X.W. Hou, Z.H. Hu, Y. Cui, W. Gao, S.P. Sun and N.F. Wang
Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have n.. Read More»
- Genet. Mol. Res. 10(4):
Relationship between carotid artery atherosclerosis and sulfatide in hypertensive patients
Authors: G. Li, R. Hu, J. Gu and H.-Z. Wu
Hypertension is a major traditional risk factor for atherosclerosis, and carotid artery intima-media thickness (IMT) is considered to be an important marker of atherosclerosis. Sulfatides have been shown to play a role in atherogenesis and vascular inflammation, resulting in atherosclerosis. This study aimed to assess the association between serum sulfati.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.16
- DOI:
- 10.4238/2015.May.11.16
Evidence for an association between haptoglobin and MnSOD (Val9Ala) gene polymorphisms in essential hypertension based on a Brazilian case-control study
Authors: A.L. Miranda-Vilela, A.K. Akimoto, P.C.Z. Alves, L.B. Ferreira, G.S. Lordelo, J.G.M. Melo, C.K. Grisolia, S.F. Oliveira and M.N. Klautau-Guimar�£es
Essential hypertension is a complex and multifactorial trait; genetic and environmental factors interact to produce the final phenotype. Studies have demonstrated association of hypertension with varied gene polymorphisms. However, demonstration of common genetic causes in the general population remains elusive. We investigate.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr973
- DOI:
- 10.4238/vol9-4gmr973
Association of the PPAR�³2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia
Authors: L. Gao*, L. Wang*, H. Yun, L. Su and X. Su
In order to determine whether Pro12Ala polymorphism of the peroxisome proliferator-activated receptor g2 (PPARg2) gene contributes to susceptibility to primary hypertension and metabolic lipid disorders, 482 unrelated subjects from Inner Mongolia were studied, including 137 healthy normotensive (controls) and 345 hypertensive .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr833
- DOI:
- 10.4238/vol9-3gmr833
Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population
Authors: Y. Yang, J.R. Xu, X.M. Liu, J. Zhou, B. Yang, M. Li and Y.J. Wang,
In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.27.6
- DOI:
- http://dx.doi.org/10.4238/2014.February.27.6
Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia
Authors: X.L. Su, H.R. Dong, M.R. Yan, H.W. Cui, L. Yang and F.Q. Han
We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cho.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.12.2
- DOI:
- 10.4238/2011.December.12.2
Pulmonary hypertension in patients with stage 1-3 chronic kidney disease
Authors: Q.M. Yang and X.R. Bao
Pulmonary hypertension (PH) secondary to chronic kidney disease (CKD) is common, but in stages 1-3 CKD patients, it remains unclear. We sought to evaluate the prevalence of PH and elucidate the possible pathogenesis in Chinese patients with early stage kidney disease. Doppler-estimated pulmonary systolic artery pressure (PASP).. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.25
- DOI:
- 10.4238/2014.July.25.25
Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension
Authors: X.M. Wang, K. Shi, J.J. Li, T.T. Chen, Y.H. Guo, Y.L. Liu, Y.F. Yang and S. Yang
This study investigated the effects of angiotensin II (AngII) intervention, using captopril and losartan, on the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), and collagen in rats with pulmonary hypertension, in an effort to understand mechanisms underlying pulmonary vascular remodeling. A total.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.17
- DOI:
- 10.4238/2015.March.6.17