Hypertension
Association of the CYP4F2 rs2108622 genetic polymorphism with hypertension: a meta-analysis
Authors: X.-H. Luo, G.-R. Li and H.-Y. Li
Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.1
- DOI:
- 10.4238/2015.November.25.1
Effect of all-trans retinoic acids (ATRA) on the expression of �±-smooth muscle actin (�±-SMA) in the lung tissues of rats with pulmonary arterial hypertension (PAH)
Authors: Y. Xin1, J.-Q. Lv1, Y.-Z. Wang2, J. Zhang1 and X. Zhang1
The effect of all-trans retinoic acid (ATRA) on the expression of α-smooth muscle actin (α-SMA) in rats with pulmonary arterial hypertension (PAH) was studied, and the mechanism of the effect of ATRA on PAH was proposed. Thirty male SD rats were randomly divided into normal control, monocrotaline (MCT) model, and ATRA [30 mg/(kg.day)]intervent.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.15
- DOI:
- 10.4238/2015.November.13.15
Interaction of six candidate genes in essential hypertension
Authors: D.C. Hu, X.L. Zhao, J.C. Shao, W. Wang, J. Qian, A.H. Chen, H.Q. Zhang, H. Guo, J. Jiang and H.Y. Li
We explored the interaction of 6 candidate genetic mutations in essential hypertension (EH). The mutations AGT M235T, ACE I/D, eNOS Glu298Asp, ET-2 A985G, ANP T2238C, and NPRC A-55C were detected using a genechip microarray in 100 patients with EH and 97 controls from the Han population living in the Yunnan Province of China. Risks of EH were evaluated wi.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.14
- DOI:
- 10.4238/2014.October.20.14
Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis
Authors: R. Zeng, Q.P. Wang, M.X. Fang, J. Zhuang and R.X. Fan
The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.19
- DOI:
- 10.4238/2015.October.21.19
G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals
Authors: L.L. Gao, X. Ding, D.M. Xie, M. Yang and B.R. Dong
The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We include.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.22
- DOI:
- 10.4238/2015.November.30.22
Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis
Authors: F. Zhang Y. Yang D. Hu H. Lei Y. Wang
Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.7
- DOI:
- 10.4238/2012.September.26.7
Inhibitory effects of spironolactone on myocardial fibrosis in spontaneously hypertensive rats
Authors: H. Zhao, D.W. Gu, H.T. Li, Q.F. Ge and G.P. Li
This study evaluated the inhibitory effects of spironolactone, a non-selective aldosterone receptor antagonist, on hypertension-induced myocardial fibrosis. Collagen I and III contents was detected in the myocardial tissue of spontaneously hypertensive rats (SHRs) after spironolactone administration. Twenty male SHRs were assigned to the spironolactone gr.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.August.28.17
- DOI:
- http://dx.doi.org/10.4238/2015.August.28.17
Association study of circulating endothelial progenitor cells and plasma prostacyclin levels in pulmonary hypertension rats
Authors: Y. Song
The aim of this study was to investigate the correlation between circulating endothelial progenitor cell (EPC) levels and plasma prostacyclin (PGI2) concentrations in pulmonary hypertension (PH) rat models. Monocrotaline was used to induce PH, and the number of CD34/Flk-1-double-positive mononuclear cells in peripheral CD45-ne.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.11
- DOI:
- 10.4238/2014.January.21.11
Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China
Authors: J.Q. Liang, M.R. Yan, L. Yang, Q. Suyila, H.W. Cui and X.L. Su
Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE). We therefore investigated the association between a CYP4A11 polymorphism (rs9333025) with hypertension in the Mongolian and Han ethnic groups. We studi.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.20
- DOI:
- 10.4238/2014.January.21.20
CAMK4 gene variation is associated with hypertension in a Uygur population
Authors: S.Z. Chen1,2, Z. Wang1,2, L.N. Zhang1, G.L. Lu2, C.M. Zhou1, D.W. Wang1,Z.M. Tang3, L. Wang2, L. Qin2 and Z.H. Zhai2
Considering that calcium/calmodulin-dependent kinase 4 (CAMK4) plays a pivotal role in blood pressure regulation, we investigated the association between a CAMK4 polymorphism (rs10491334) and hypertension in the Han, Kazak, and Uygur ethnic groups. We studied 1224 patients with hypertension and 967 normotensive controls classified into three ethnic groups.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017207
- DOI:
- 10.4238/gmr.15017207