Hypertension
Association of TSC gene variants and hypertension in Mongolian and Han populations
Authors: P.Y. Chang, L.G. Zhao and X.L. Su
We investigated a possible association between genetic variations in the thiazide-sensitive Na-Cl cotransporter (TSC) gene and essential hypertension (EH) in the Mongolian and Han ethnic groups in Inner Mongolia. Our study included 385 unrelated Mongolian herdsmen and 523 Han farmers. Nine tagSNPs of TSC were identified from t.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1227
- DOI:
- 10.4238/vol10-2gmr1227
Lack of association of variants of the renal salt reabsorption-related genes SLC12A3 and ClC-Kb and hypertension in Mongolian and Han populations in Inner Mongolia
Authors: P.Y. Chang, X.G. Zhang and X.L. Su
Abnormalities in renal sodium chloride and water reabsorption play important roles in the development of hypertension. Mutations in the genes involved in renal sodium chloride reabsorption can affect blood pressure. Recently, the R904Q variant of the sodium/chloride transporters, member 3 (SLC12A3) gene and the T481S variant o.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1165
- DOI:
- 10.4238/vol10-2gmr1165
Relationship between EPHX2 gene polymorphisms and essential hypertension in Uygur, Kazakh, and Han
Authors: X.L. Zhu, L. Wang, Z. Wang, S.Z. Chen, W.Q. Zhang and M.M. Ma
We investigated the association between rs751141 polymorphisms in the EPHX2 gene and essential hypertension in Uygur, Kazakh, and Han subjects in Xinjiang, China. A total of 302 essential hypertensive patients in Uygur, 267 in Kazakh, and 368 in Han, as well as 323 normotensive controls in Uygur, 284 in Kazakh, and 348 in Han were enrolled in this study. .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.11
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.11
RT-qPCR assay on the vitamin D receptor gene in type 2 diabetes and hypertension patients in Turkey
Authors: H.C. Vural1 and E. Maltas
RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PC.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.14.1
- DOI:
- 10.4238/2012.March.14.1
Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and E
Authors: J.X. Xu, L. Su, L. Chen and J.X. Lin
This study aimed to investigate the influence of acute glycemic load on vascular endothelial function in patients with hypertension and to evaluate the protective effect of vitamins C and E during the acute glycemic phase. We randomly selected 39 hypertensive patients and 21 normal subjects and divided them into 3 groups: 75 g.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.9
- DOI:
- 10.4238/2014.September.5.9
Analysis of FOS, BTG2, and NR4A in the function of renal medullary hypertension
Authors: Y.B. Wu, W.D. Zang, W.Z. Yao, Y. Luo, B. Hu, L. Wang and Y.L. Liang
The aim of this study was to identify differentially expressed genes (DEGs) in renal medullary hypertension and reveal their pathogenic mechanisms. We downloaded the gene expression profile of GSE28360 from the Gene Expression Omnibus database. The profile included 14 samples (5 normal and 9 hypertension). The DEGs in normal and disease samples were disti.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.4
- DOI:
- 10.4238/2013.September.19.4
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population
Authors: B. Yang, J.R. Xu, X.M. Liu, Y. Yang, X.F. Na, M. Li and Y.J. Wang
We investigated a possible association of polymorphism of the eNOS gene and essential hypertension in the Chinese Hui population; polymorphisms of rs2070744 (T>C), rs1799983 (G>T), rs1800780 (A>G), and rs3918181 (A>G) loci of the eNOS gene were examined. We found that the genotypic frequencies at rs1799983 and rs1800780 loci differed significa.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.26.2
- DOI:
- 10.4238/2013.March.26.2
Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon
Authors: S.M. Ghogomu, N.E. Ngolle, R.N. Mouliom and B.F. Asa
The association of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and essential hypertension has been reported but with controversial results in diverse populations in Asia and Europe, thereby suggesting a dependency on ethnicity. The aim of this study was to investigate the association between the MTHFR C677T polymorphism and ess.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017462
- DOI:
- 10.4238/gmr.15017462
Correlation between natriuretic peptide receptor C (NPR3) gene polymorphisms and hypertension in the Dai people of China
Authors: H. Sun, Z.Q. Yang, S.Y. Liu, L. Yu, K. Huang, K.Q. Lin, J.Y. Chu and X.Q. Huang
Hypertension affects one-fifth of the world population. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that correlated with hypertension in large samples. However, the genetic mutations leading to hypertension might differ among various populations, as they have different origins and are subjected to .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.2
- DOI:
- 10.4238/2015.August.3.2
Molecular characterization of a Han Chinese family with essential hypertension
Authors: J.F. Zhu, X. Zhang and L. Ling
Mutations in the mitochondrial genome have been found to be associated with essential hypertension. Here, we report the clinical and molecular characterization of a three-generation Han Chinese family with maternally inherited hypertension. Most strikingly, this pedigree exhibited a high penetrance of hypertension. Sequence an.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028084
- DOI:
- 10.4238/gmr.15028084