Hypertension
Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients
Authors: R. Nemati, J. Lu, V. Ramachandran, A. Etemad, M. Heidari, M.J. Yahya, R. Roozafzoon and P. Ismail
The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted using a comm.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026241
- DOI:
- 10.4238/gmr.15026241
Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations
Authors: P.Y. Chang, L. Qin, P. Zhao and Z.Y. Liu
Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases. In this study, we investigated the association between RGS5 gene variants and hypertension in the Mongolian and Han populations. Peripheral blood was obtained from 429 unrelated Mongolian herdsmen and 416 Han farmers [including essential hyperte.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.37
- DOI:
- 10.4238/2015.December.21.37
Polymorphisms of the angiotensin II type 1 receptor gene affect antihypertensive response to angiotensin receptor blockers in hypertensive Chinese
Authors: H.T. Gong, X.L. Ma, B.X. Chen, X.Y. Xu, Q. Li, C.X. Guo and F.H. Du
The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.21.2
- DOI:
- 10.4238/2013.June.21.2
Mitochondrial transfer RNA mutations and hypertension
Authors: S.L. Yin, C. Lan, H. Pei, and Z.Q. Zhu
Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt-tRNA metabolism, thereby worsening mitochondrial dysfunction and resulting in hypertension. mt-tRNA is .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.42
- DOI:
- 10.4238/2015.December.21.42
Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study
Authors: T. Hasi, L. Hao, L. Yang and X.L. Su
Mongolians are known as heavy drinkers, and they have a high incidence of essential hypertension, which may be an associated pathology. We examined a possible association of essential hypertension and polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene in Mongolians from Inner Mongolia. Single nucleotide polymorphism rs6.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1056
- DOI:
- 10.4238/vol10-1gmr1056
Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population
Authors: J.Q. Liang, Y.G. Xi, C.Y. An and X.L. Su
Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotypin.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.9
- DOI:
- 10.4238/2015.August.21.9
Serum soluble RAGE level inversely correlates with left ventricular hypertrophy in essential hypertension patients
Authors: Q. Liu, H.B. Chen, M. Luo, H. Zheng
Soluble receptor for advanced glycation end-products (sRAGE) acts as a decoy to prevent interaction between RAGE and its pro-inflammatory ligands. sRAGE levels have been found to decrease in chronic inflammatory diseases, including hypertension. However, few data have been reported concerning the association between serum sRAG.. Read More»
- Genet. Mol. Res. 15(2):
Association of TNF-�± G308A gene polymorphism in essential hypertensive patients without type 2 diabetes mellitus
Authors: N. Ghodsian, M. Akhlaghi, V. Ramachandran, F. Heidari, P. Haghvirdizadeh, S.A. Eshkoor, A. Etemad, J.A. Jamaluddin and P. Ismail
This study aims to investigate the effects of tumor necrosis factor alpha (TNF-α) G308A gene polymorphism on essential hypertension (EHT) with or without type 2 diabetes mellitus (T2DM). The project was conducted on buccal epithelial and blood cells for case and control patients, respectively. Epithelial cells were obtained from the inner part of th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.4
- DOI:
- 10.4238/2015.December.29.4
Association of SNPs in the PPAR�³ gene and hypertension in a Mongolian population
Authors: L. Yang, R.G. Tian, P.Y. Chang, M.R. Yan and X.L. Su
The association of single nucleotide polymorphisms (SNPs) in PPARγ with hypertension is controversial. The aim of the present study was to clarify the contributions of PPARγ genetic variants to hypertension through an association study. A total of 414 unrelated Mongolian herdsmen and 524 Han farmers were included in this study. Fourteen intron.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.39
- DOI:
- 10.4238/2015.December.29.39
Using bradykinin-potentiating peptide structures to develop new anti hypertensive drugs
Authors: Jorge Hernandez Fernandez, Goran Neshich and Antonio Carlos M. Camargo
Angiotensin I-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase expressed in endothelial, epithelial and neuroepithelial cells. It is composed of two domains, known as N- and C-domains, and it is primarily involved in blood pressure regulation. Although the physiological functions of ACE are not limited to its cardiovas.. Read More»
- Genet. Mol. Res. 3(4):