NNT and NNT-AS1 expression levels are not different between bipolar patients and healthy subjects
Authors: Soudeh Ghafouri-Fard, Mohammad Taheri, Vahid Kholghi Oskooie, Mir Davood Omrani, Arezou Sayad
Nicotinamide nucleotide transhydrogenase (NNT) participates in redox and energy interconnections. Nnt silencing in N27 dopaminergic cells has changed basal, extra, and greatest mitochondrial oxygen absorption rates and made these cell vulnerable to constant upsurges in H2O2. NNT-antisense RNA1 (NNT-AS1) is transcribed from the opposite stand of NNT gene a.. Read More»
- Genet. Mol. Res. 18(1):
Relationship between melanoma-associated antigen 1 (MAGE-A1) gene polymorphisms and colorectal cancer development
Authors: Mikhlid Almutairi and Abdelhabib Semlali
In the Saudi population, colorectal cancer (CRC) is the first and third most common malignancy among males and females, respectively. The CRC risk is associated with the expression of certain genes, which can be used for prognoses and for finding screening-related biomarkers. One such gene is melanoma-associated antigen 1 (MAGE-A1); however, little is kno.. Read More»
- Genet. Mol. Res. 18(4):
Glioblastoma in a 20-year-old female patient after Chikungunya infection
Authors: L.O. Mour�£o, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves
We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX pos.. Read More»
- Genet. Mol. Res. 18(1):
Investigation of the role of apoptosis, necroptosis and DNA damage signaling pathways in multiple sclerosis
Authors: Romina Dastmalchi, Arezou Sayad, Mir Davood Omrani, Soudeh Ghafouri-Fard, Shahram Arsang-Jang, Mehrdokht Mazdeh, Mohammad Taheri*
Multiple sclerosis (MS) as the most common autoimmune disorder in the central nervous system is a major health problem. MS is a complex disease with multiple environmental and genetic factors participating in it. In the present study, we evaluated the expression of 3 genes named BCL2, CASP2 and CASP8 in peripheral blood of 50 MS patients and 50 healthy co.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039937
- DOI:
- http://dx.doi.org/10.4238/gmr16039937
Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer
Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali
Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R g.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039935
- DOI:
- http://dx.doi.org/10.4238/gmr16039935
AtBTH1, a BTB domain-containing protein, influences sugar-responsive germination and seedling growth in Arabidopsis
Authors: J.E. Hwang, Y.J. Kim, M.H. Shin, J. Park, W. Choi, D.J. Yun and H.C. Park
Sugars function as signal molecules that regulate gene expression, growth, and development in plants, animals, and yeasts. As a contribution to understanding the molecular mechanisms of sugar responses, we identified and characterized an Arabidopsis thaliana BTB domain-containing protein of the H subfamily 1 (designated AtBTH1). The relative expression le.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039932
- DOI:
- http://dx.doi.org/10.4238/gmr16039932
MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection
Authors: Patricia Milhoransa, Carolina Caruccio Montanari, Mariane Dos Santos, Marina Sieber, Roberto Ceratti Manfro
Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has man.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039933
- DOI:
- http://dx.doi.org/10.4238/gmr16039933
Genetic variability in morphological characters among Fig tree accessions Fig genetic conservation
Authors: Maria Gabriela Fontanetti Rodrigues*, LaÃ?Âs Naiara Honorato Monteiro, Antonio FlÃ?¡vio Arruda Ferreira, Tatiane Paes Dos Santos, Bruno Ettore Pavan, Vitos AntÃ?´nio Benites Neves, Aparecida ConceiÃ?§Ã?£o Boliani
Fig is among the twenty main fruits exported by Brazil, which is the eighth largest producer of fig in natura in the world. The characterization of active germplasm banks (AGBs) of fig has thus become an important line of research, as it is necessary to gather information from this to carry out adequate management projects. The objective of this study was.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039931
- DOI:
- http://dx.doi.org/10.4238/gmr16039931
Estimative of genetic diversity in germ-plasm of elephant grass using the Gower algorithm
Authors: A.K.F. Vidal, R.F. Daher, R.S. Freitas, W.F. Stida, B.R. da S. Menezes, A.V. Pereira, V.B. da Silva, F.D. Tardin and L.J. da S. de Oliveira
This work aimed at estimating the genetic divergence among 85 accessions of elephant-grass using the Gower algorithm for the joint study of quantitative and qualitative traits. The experiment was conducted in the city of Campos dos Goytacazes, Rio de Janeiro state, Brazil, with of 85 elephant-grass genotypes. It was applied a randomized block experimental.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039934
- DOI:
- http://dx.doi.org/10.4238/gmr16039934
High concentrations of sacharose lead to metabolic changes that favor the formation of co-products in ethanolic fermentation by Zymomonas mobilis
Authors: Bruno Souza dos Santos, TÃ?ºlio Diego da Silva, Danilo Cavalcanti Ramos, Carolina Barbosa Malafaia, LÃ?Âvia Caroline Alexandre de AraÃ?ºjo, Mariana Gomes Vidal Sampaio, Lucas Weba Soares, Alexandre Gomes da Silva, Fabiane Rabelo da Costa Batista, Patricia Maria Guedes Paiva, LuÃ?Âs ClÃ?¡udio Nascimento da Silva, Maria Tereza dos Santos Correia, Glicia Maria Torres Calazans and Marcia Vanusa da Silva
Z. mobilis has attracted great biotechnology interest in recent decades due to its unique metabolism and the ability to produce bioethanol from simple sugars in an effectively and quickly way. Z. mobilis also produce other bioactive products as fructose, gluconic acid, sorbitol, levan, fructo-oligosaccharides. This study aimed to identify proteins differe.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039929
- DOI:
- http://dx.doi.org/10.4238/gmr16039929