Table of Contents | Genet. Mol. Res.2017(4)
Alcohol metabolizing gene polymorphisms and their relationship with oral cancer risk and clinicopathological features
Authors: J.T. Takamori, M. Santos, G. T. Peterle, L. Rossi, O. A. Curioni, D. Gazito, L. L. Maia, I. D. Louro, M. M. de Oliveira, J. G. dos Santos, R. A. Moyses, P. M. Cury, T. N. Toporcov, J. L. Kanda, A. M. A. da Silva, M. B. de Carvalho
Oral cancer incidence is higher in individuals between the fifth and seventh decades of life, but some studies indicate a decreasing age trend. From the epidemiological point of view, alcohol consumption is associated with the emergence of oral cancer by interfering with mechanisms of DNA synthesis and repair. From a genetic s.. Read More»
Genet. Mol. Res. 16(4): gmr16039829
DOI: 10.4238/gmr16039829
A targeted NGS approach to identify a c.352C>G variant in the TWIST1 gene in an Albanian family with Saethre�Chotzen syndrome
Authors: Elena Manara, Denisa Guraj, Francesca Fanelli, Paolo E Maltese, Anila Babameto-Laku, Natale Capodicasa , Sandro Michelini, Bruno Amato, Matteo Bertelli
A targeted next generation sequencing (NGS) approach analysing contemporaneously 20 different genes mainly involved in craniosynostosis was adopted to molecularly diagnose the family of a 2-years old girl affected by Saethre–Chotzen syndrome, a syndromic form of craniosynostosis. The identified pathogenic variant in the .. Read More»
Genet. Mol. Res. 16(4): gmr16039828
DOI: 10.4238/gmr16039828
Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.
Authors: Lingkang Wu, Yingchao Liu, Liangliang Shi, Bingbing Zhang, Ana Carolina Picolo Pasian and Andrei Moroz
This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related k.. Read More»
Genet. Mol. Res. 16(4): gmr16039818
DOI: 10.4238/gmr16039818
Mitochondrial diversity in the populations of Pediculus humanus capitis across eastern south of Tehran Province, Iran
Authors: Fatemeh Ghandali, Neda Kheradpir, Siamak Yousefi Siahkalroudi
Pediculus humanus capitis is a major obligate and district ecto-parasite of human which is distributed in different parts of the world and is under several research projects for population management and molecular analysis. In this study, one hundred and seventy head lice were collected from school girls at different high scho.. Read More»
Genet. Mol. Res. 16(4): gmr16039826
DOI: 10.4238/gmr16039826
Transferability of heterologous microsatellite loci between species of Euterpe genus
Authors: H.S.F.S Az�ªvedo, F.D Benvindo, L.N. Cavalcante, M. Haverroth, L.H.O. Wadt, T. Campos
Euterpe precatoria, popularly known as “açaí-do-amazonas”, has agronomic, technological and economic potential and has been gaining prominence with the commercialization of its fruits. The production of this açaí-do-amazonas is based on extractivism and management practices have been rec.. Read More»
Genet. Mol. Res. 16(4): gmr16039825
DOI: 10.4238/gmr16039825
Epidemiological and pathological studies on the helminthic parasites in native chickens of Tabriz city, Iran
Authors: Garedaghi yagoob, Arash Khaki, Sayed Haidar Abbas Raza,Rajwali Khan, Li Hao, Seyed Mahdi Hosseini, Sherein S. Abdelgayed and Mohib Ullah Kakar
A study of intestinal helminthic parasites of domestic chickens was carried out in Tabriz city, Iran during 2016. One hundred (100) gastrointestinal samples were examined in necropsied chickens microscopically using the lactophenol and carmine-acid staining technique. The result showed a high prevalence of intestinal parasitic.. Read More»
Genet. Mol. Res. 16(4): gmr16039824
DOI: 10.4238/gmr16039824
Clinical and molecular findings in an Albanian family with familial adenomatous polyposis
Authors: P. E. Maltese, G. Di Saverio, E. Manara, F. Fanelli, N. Capodicasa, D. Guraj, I. Shehaj, B. Amato, A. Babameto-Laku, S. Michelini , M. Bertelli
Purpose: Familial adenomatous polyposis is an inherited precancerous condition characterized by multiple colorectal polyps. This brief report describes three generations of a family with a history of colorectal cancer in which genetic testing was useful for detecting individuals at risk. Methods: A next generation sequencing c.. Read More»
Genet. Mol. Res. 16(4): gmr16039823
DOI: 10.4238/gmr16039823
Case report of X-linked hyper-IgM syndrome with acquired toxoplasmic encephalitis
Authors: Guoyan Lu, Dan Yu
The X-linked hyper-IgM (XHIGM; HIGM1) syndrome is an uncommon primary immunodeficiency disease caused by mutations in the gene for CD40 ligand and characterized by normal or elevated serum IgM, low or absent serum levels of IgG, IgA and IgE, and defective T-cell function. Here we reported a case of XHIGM with acquired toxoplas.. Read More»
Genet. Mol. Res. 16(4): gmr16039822
DOI: 10.4238/gmr16039822