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Human Genetics   Research Article
Genotypes within the prolactin and growth hormone insulin-like growth factor-I pathways associated with milk production in heat stressed Holstein cattle: Genotypes and milk yield in heat stressed Holstein cows

Authors: Hern�¡ndez-Cordero, M. A. S�¡nchez-Castro, R. Zamorano- Algandar, P. Luna-Nev�¡rez, G. Rinc�³n, J. F. Medrano4, S. E. Speidel, R. M. Enns and M. G. Thomas

The association of single nucleotide polymorphisms (SNPs) within genes of the prolactin (PRL), growth hormone (GH) and insulin-like growth factor-I (IGF1) pathways with 305-day milk yield (MY305) were evaluated in heat-stressed Holstein cows. Ambient temperature and relative humidity were used to calculate a temperature-humidi.. Read More»

Genet. Mol. Res. 16(4): gmr16039821

DOI: 10.4238/gmr16039821

Plant Genetics   Research Article
Differential expression of dormancy-Associated genes in fastigiata and hypogaea peanut

Authors: M.F.C. Silva, C.R.C. Silva, L.M. Lima, JPC Ramos, and R.C. Santos

Seed dormancy is a temporary replacement state observed in some higher plants, which prevents germination under unfavorable conditions. In several species, dormancy process is triggered by hormonal factors, initiated by ABA and precursor enzymes. In this work, we investigated the relationship between dormancy and the expressio.. Read More»

Genet. Mol. Res. 16(4): gmr16039820

DOI: 10.4238/gmr16039820

Animal Genetics   Research Article
BmICE-2 interference vector construction and its silencing effect in the BmN-SWU1 cells

Authors: Hua-Shan Yi and Xianping Ma

Investigate the function of BmICE-2 gene in silkworm cells by constructing a BmICE-2 interference vector and analysing its interference effect. Online RNAi design software was used to predict the interference target sequence of Bmice-2. An optimized sequence was selected and inserted into the backbone of interference microRNA... Read More»

Genet. Mol. Res. 16(4): gmr16039819

DOI: 10.4238/gmr16039819

Human Genetics   Research Article
Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism

Authors: Lingkang Wu, Yingchao Liu, Liangliang Shi, Bingbing Zhang, Ana Carolina Picolo Pasian and Andrei Moroz

This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related k.. Read More»

Genet. Mol. Res. 16(4): gmr16039818

DOI: 10.4238/gmr16039818

Plant Genetics   Research Article
Genetics Analysis of the Biggest Cashew Tree in the World

Authors: F.P.M. do Amaral, G.H. de S�¡, L.A. Filgueiras, F.S. Santos Filho, C.J.R. Santos Soares, M.P.M. do Amaral, S.E. dos Santos Valente, A. N. Mendes

This study performed a genetic study of several canopies of Anacardium occidentale L. specimen called "Cashew King" (Cajueiro da Praia-PI, Brazil) in order to assess whether all canopies belong to the same plant. Leaves were collected from  different distant points, and preserved for analysis of DNA. The analysi.. Read More»

Genet. Mol. Res. 16(4): gmr16039817

DOI: 10.4238/gmr16039817

Human Genetics   Research Article
DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer

Authors: T.D. Silva, A.V. Felipe, V.M. Vidigal, S.S. Saad, N.M. Forones

Purpose: Epigenetic changes can be detected in precancerous lesions, suggesting that may be involved in the early stages of carcinogenesis. The methylation of specifics genes has been correlated with the outcome of many different types of cancers. This study compared the levels of DNA methylation between normal and tumor tissu.. Read More»

Genet. Mol. Res. 16(4): gmr16039816

DOI: 10.4238/gmr16039816

Human Genetics   Research Article
Comparative Study of Blood-Derived Scaffolds for the Culture of Human Adipose Derived Stem Cells (ASCS) and Dermal Fibroblasts

Authors: Helga Caputo Nunes, Rosana Rossi Ferreira,Ana Carolina Picolo Pasian, Andrei Moroz, Bruno Martinucci, Michele Janegitz Acorci Valerio,S�©rgio Alexandre Alc�¢ntara dos Santos, Henrique de Souza Vieira,S�©rgio Luis Felisbino, Elenice Deffune, Fl�¡via Karina Delella

This study aimed to compare the performance of bloodderived scaffolds with a well-known and accepted scaffold, chitosan, in maintaining cell cultures of ASCs and fibroblasts for future wound healing applications. Cells were characterized, immunophenotyped and cultivated into the following scaffolds: 1) Chitosan (CH, control), .. Read More»

Genet. Mol. Res. 16(4): gmr16039807

DOI: 10.4238/gmr16039807

Plant Genetics   Research Article
Characterization of the complete Chloroplast genome of Correa carmen, a valuable winter-flowering shrub

Authors: Minghui Chen, Yuxia Zong, Shiping Cheng, Zhilu Zhang

Correa carmen is considered important because of its considerable ornamental and economic value. The most striking characteristic of C. carmen flowers is their long winter-flowering period. In the present study, we generated the first complete C. carmen chloroplast genome sequence based on Illumina paired-end sequencing data. .. Read More»

Genet. Mol. Res. 16(4): gmr16039815

DOI: 10.4238/gmr16039815