Medical Genetics
Comparative and joint analyses of gene expression profiles under drought and rewatering in Arabidopsis
Authors: Z.H. Xu and W.R. Wu
Drought is a major limiting factor in crop production. Rewatering is a process opposite to drought, allowing plants to recover to their normal physiological state. To understand more thoroughly the set of genes involved in plant response to drought, we comparatively and jointly analyzed the microarray data of drought and rewatering experiments in Arabidop.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.6
- DOI:
- 10.4238/2013.September.13.6
A molecular marker for in situ genetic resource conservation of Capsicum annuum var. acuminatum (Solanaceae)
Authors: N. Kaewdoungdee and T. Tanee
The Thailand cultivar pepper ‘phrik man bangchang’ (Capsicum annuum var. acuminatum, Solanaceae) was originally cultivated in the Bangchang Subdistrict, Amphawa District in Samut Songkhram Province. The cultivated areas are limited; we verified its distribution in Thailand for in situ ‘phrik man bangchang’ genetic resource conserva.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.10
- DOI:
- 10.4238/2013.February.28.10
Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population
Authors: X.D. Fu, X.Q. Sun, H.Y. Wang, J.F. Guo, G.Z. Zhang and Q.H. Xu
Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.13
- DOI:
- 10.4238/2013.September.19.13
Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations
Authors: F.R. Shen , C.Y. Yan, M. Liu, Y.H. Feng and Y.G. Chen
Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were inv.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.12
- DOI:
- 10.4238/2013.September.19.12
Xuemaitong granules attenuate carotid atherosclerosis by decreasing the expression of CD14+CD16+ monocytes, IL-6, TNF-�±, and hsCRP
Authors: Q. Zhang, G. Qian and Z. Ding
Carotid atherosclerosis (CAS) has been extensively studied because its position can be easily observed. Our objective was to investigate the effects of Xuemaitong granules on the generation and activation of CD14+CD16+ monocytes on the inflammatory reaction in CAS patients. In this study, 22 male apolipoprotein E (apoE)-defici.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.19
- DOI:
- 10.4238/2014.September.12.19
Therapeutic influence of intraperitoneal injection of Wharton�s jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis
Authors: H.J. Luo,X.M. Xiao,J. Zhou and W. Wei
To study the effect of Wharton’s jelly-derived mesenchymal stem cells (WJMSCs) on the rat salpingitis model, 50 female Wistar rats were randomly divided into one control and five model groups. Mixed bacteria were injected into the oviducts of model groups. The treated acute and chronic groups received intraperitoneal injections of WJMSCs (1 x 106) o.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.10
Clinical value of concurrent radiochemotherapy in cervical cancer and comparison of ultrasonography findings before and after radiochemotherapy
Authors: W.M. Yan,X.Z. Li,Z.L. Yu,J. Zhang and X.G. Sun
Herein, we investigated the clinical value of concurrent radiochemotherapy for patients with advanced cervical cancer and its effects on adverse clinical symptoms. Forty patients with cervical cancer were recruited from January 2011 to January 2014 for this study. Participants were randomly allocated into a test or control group, with 20 patients in each .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.13
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.13
Evaluation of the function status of the ulnar nerve in carpal tunnel syndrome
Authors: J. Zhang,N. Liu,Y.W. Wang,Z.C. Zhang,L.N. Zheng and J. Zhu
Many carpal tunnel syndrome (CTS) patients have symptoms in both the median and ulnar digits more frequently than in the median digits alone. This is possibly because of close anatomical contiguity of the carpal tunnel and Guyon’s canal, and the high pressure may also affect the latter, causing indirect compression of ulnar nerve fibers. Thus, we ev.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.17
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.17
Genome-wide pathway analysis in amyotrophic lateral sclerosis
Authors: Y.H. Lee and G.G. Song
The aims of this study were to identify candidate singlenucleotide polymorphisms (SNPs) and mechanisms of amyotrophic lateral sclerosis (ALS) and to generate SNP-to-gene-to-pathway hypotheses. An ALS genome-wide association study (GWAS) dataset that included 483,051 SNPs in 276 patients with ALS and 271 controls of European descent was used in this study... Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.19
- DOI:
- 10.4238/2015.June.11.19
Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico
Authors: G. Jaramillo-Rangel, M. Ortega-MartÃ?Ânez, R.M. Cerda-Flores andH.A. Barrera-SaldaÃ?±a
Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The pur.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.22
- DOI:
- 10.4238/2015.June.11.22