Medical Genetics
Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico
Authors: G. Jaramillo-Rangel, M. Ortega-MartÃ?Ânez, R.M. Cerda-Flores andH.A. Barrera-SaldaÃ?±a
Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The pur.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.22
- DOI:
- 10.4238/2015.June.11.22
Qualitative analysis of the vaginal microbiota of healthy cattle and cattle with genital-tract disease
Authors: N.F. Rodrigues, J. K�¤stle, T.J.D. Coutinho, A.T. Amorim, G.B. Campos, V.M. Santos, L.M. Marques, J. Timenetsky and S.T. de Farias1
The microbial community of the reproductive apparatus, when known, can provide information about the health of the host. Metagenomics has been used to characterize and obtain genetic information about microbial communities in various environments and can relate certain diseases with changes in this community composition. In this study, samples of vaginal .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.4
- DOI:
- 10.4238/2015.June.12.4
Novel and recurrent COL7A1 mutations in Chinese patients with dystrophic epidermolysis bullosa pruriginosa
Authors: K.J. Zhu, C.Y. Zhu*, Y. Zhou and Y.M. Fan
Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of dystrophic epidermolysis bullosa (DEB). This disease is characterized by severe itching, lichenoid nodules or prurigo-like lesions, and linear scarring with a predilection for the extensor limbs. Pathogenic mutations in the type VII collagen alpha 1 (CO.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.26
- DOI:
- 10.4238/2014.September.12.26
Protective effects of remifentanil preconditioning on cerebral injury during pump-assisted coronary artery bypass graft
Authors: T.Z. Zhang, J. Zhou, Q. Jin, Y.J. Sun, Y.G. Diao, Y.N. Zhang and Z. Zhang
The protective effects of remifentanil preconditioning on serum superoxide dismutase (SOD) and malondialdehyde (MDA) during pump-assisted coronary artery bypass graft (CABG) were investigated. Forty pump-assisted CABG patients were randomly divided into a remifentanil preconditioning group (R group) and a control group (C grou.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.3
- DOI:
- 10.4238/2014.September.26.3
Expression profiling of CEACAM6 associated with the tumorigenesis and progression in gastric adenocarcinoma
Authors: X. Deng, P. Liu, Y. Zhao and Q. Wang
Carcinoembryonic antigen-related cellular adhesion molecule 6 (CEACAM6) is a member of the immunoglobulin superfamily and has been recently reported to affect the neoplastic, metastatic, and invasive ability of malignant cells by regulating intracellular signaling pathways during tumorigenesis and progression. We investigated .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.6
- DOI:
- 10.4238/2014.September.26.6
Association between rs1049673 polymorphism in CD36 and premature coronary heart disease
Authors: J.J. Che, Y.X. Shao, G.P. Li
Risk factors for premature coronary heart disease in China can be multiple; we investigated Chinese Han patients with premature coronary heart disease and a possible association with CD36 polymorphism at rs1049673, rs7755, and rs321159 sites. Outpatients were recruited according to chest X-ray coronary arteriography results; t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.8
- DOI:
- 10.4238/2014.September.26.8
IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population
Authors: G.Q. Sun, G.D. Wu, Y. Meng, B. Du and Y.B. Li
We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between Janu.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.9
- DOI:
- 10.4238/2014.September.26.9
Decreased TIM-3 mRNA expression in peripheral blood mononuclear cells from nephropathy patients
Authors: X.Z. Cai, N. Liu,Y. Qiao, S.Y. Du, Y. Chen, D. Chen, S. Yu and Y. Jiang
Increasing evidence shows that TIM-1 and TIM-3 influence chronic autoimmune diseases, and their expression levels in immune cells from nephritic patients are still unknown. Real-time transcription-polymerase chain reaction analysis was used to determine expression levels of TIM-1 and TIM-3 mRNA in peripheral blood mononuclear cells (PBMCs) from 36 patient.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.7
- DOI:
- 10.4238/2015.June.12.7
Osteoprotegerin polymorphisms in Chinese Han patients with rheumatoid arthritis
Authors: X.H. Ye, J.L. Chen and R.P. Liu
In order to investigate the association between osteoprotegerin (OPG) gene polymorphisms and rheumatoid arthritis (RA), we studied OPG rs3102735 T/C and rs2073618 G/C polymorphisms in a Chinese Han population comprising 574 patients with RA and 804 controls. Genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.11
- DOI:
- 10.4238/2015.June.12.11
Association of miR-21 with esophageal cancer prognosis: a meta-analysis
Authors: S.-W. Wen, Y.-F. Zhang, Y. Li, Z.-X. Liu, H.-L. Lv, Z.-H. Li, Y.-Z. Xu, Y.-G. Zhu and Z.-Q. Tian
The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.12
- DOI:
- 10.4238/2015.June.12.12