Medical Genetics
Roles of oxidative DNA damage of bone marrow hematopoietic cells in steroid-induced avascular necrosis of femoral head
Authors: Z.Q. Zhao, R. Bai, W.L. Liu, W. Feng, A.Q. Zhao, Y. Wang, W.X. Wang, L. Sun, L.S. Wu and S.X. Cui
An animal model of steroid-induced avascular necrosis of femoral head (SANFH) was established to investigate the role of oxidative DNA damage of bone marrow hematopoietic cells in SANFH. Forty-five-month-old Japanese white rabbits (male or female, 2.5 ± 0.5 kg) were randomly divided into groups A (methylprednisolone + E.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017706
- DOI:
- 10.4238/gmr.15017706
Immune function of nonparenchymal liver cells
Authors: X.K. Xing, H.Y. Wu, H.G. Feng and Z.Q. Yuan
The liver is the human body largest digestive and metabolic organ, and a very important immune organ. This paper discusses the location and morphology of hepatic sinusoidal endothelial cells, dendritic cells, hepatic stellate cells, and Kupffer cells in the liver and their role in regulating immune functions. Therefore, here we provide a preliminary under.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15018524
- DOI:
- 10.4238/gmr.15018524
Acrocomia emensis (Arecaceae) genetic structure and diversity using SSR molecular markers
Authors: D.S. Neiva, A.F. Melo J�ºnior, D.A. Oliveira, V.A. Royo, M.M. Brand�£o and E.V. Menezes
Acrocomia emensis, popularly known as the creeping tucum, belongs to the family Arecaceae, and is an oilseed specie of the Brazilian Savannah. The expansion of agricultural activity has rapidly destroyed its natural habitat, leading to a decrease in its population size. Genetic studies can be used to investigate the genetic variability, and may assist wit.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017785
- DOI:
- 10.4238/gmr.15017785
WNT10A polymorphism may be a risk factor for non-syndromic hypodontia
Authors: S.J. Zhang and Z.Z. Wu2
This study was designed to determine whether polymorphisms in the gene wingless-type MMTV integration site family, member 10A (WNT10A) are associated with non-syndromic hypodontia (tooth agenesis). A case-control study was performed involving 129 subjects with sporadic non-syndromic hypodontia (cases) and 218 healthy individuals (controls). DNA was obtain.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016033
- DOI:
- 10.4238/gmr.15016033
Interleukin-17 enhances the removal of respiratory syncytial virus in mice by promoting neutrophil migration and reducing interferon-gamma expression
Authors: G. Zhang, K.F. Zhou and Z.H. Lu
The aim of this study was to observe the effect of interleukin (IL)-17 on early immune response and inflammation in the lungs of respiratory syncytial virus (RSV)-infected mice. Specific pathogen-free BALB/c mice were randomly assigned to control, RSV-infected, RSV-infected with phosphate-buffered saline, and RSV-infected + IL-17 intervention groups. The .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017002
- DOI:
- 10.4238/gmr.15017002
Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells
Authors: J.P. Li, Q. Ma and C.M. Chen
This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dose-dependent manner. Resveratrol exposure also induced an increase in Caspase-3 act.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017490
- DOI:
- 10.4238/gmr.15017490
Isolation and characterization of new microsatellite loci in Fenneropenaeus penicillatus
Authors: B.B. Li,2, Z.B. Li1,, Y.F. Ning, J.B. Shangguan, Y.S. Huang, Y. Yuan and X.Q. Mao
Fenneropenaeus penicillatus is one of the major economic shrimp species in China. In this study, 14 novel microsatellite loci were developed using the fast isolation protocol with amplified fragment length polymorphism of sequences containing repeats (FIASCO). Polymorphisms were tested in 30 individuals from a single-wild population. The results showed th.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017387
- DOI:
- 10.4238/gmr.15017387
miR-133 inhibits pituitary tumor cell migration and invasion via down-regulating FOXC1 expression
Authors: D.S. Wang, H.Q. Zhang, B. Zhang, Z.B. Yuan, Z.K. Yu, T. Yang, S.Q. Zhang, Y. Liu and X.X. Jia
Many studies have shown that microRNA (miR)-133 functions as a tumor suppressor in a variety of metastatic cancers, including breast cancer, gastric cancer, and liver fibrosis. However, the influence of miR-133 on pituitary tumor malignancy has not yet been reported. The purpose of this study was to explore the role of miR-133.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017453
- DOI:
- 10.4238/gmr.15017453
Protective effect of the n-butanol Toona sinensis seed extract on diabetic nephropathy rat kidneys
Authors: W.Z. Li, X.H. Wang, H.X. Zhang, S.M. Mao and C.Z. Zhao
The objective of this study was to observe the protective effect of the n-butyl alcohol phase of Toona sinensis seed extract on the kidneys of diabetic nephropathy (DN) rats and its preliminary mechanism. Male wistar rats were administered a normal or high-fat diet for 1 month. DN rats were divided into a model group and a pet.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017403
- DOI:
- 10.4238/gmr.15017403
Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage
Authors: L. Luo, D.H. Li, S.G. Wei, H.B. Zhang, S.B. Li and J. Zhao
Endothelial nitric oxide synthase (eNOS) is an enzyme that influences placental human chorionic gonadotropin production during gestation. Previous studies have indicated an association between eNOS activity, implantation, and maintenance of pregnancy, but proposed associations between polymorphisms of the eNOS gene and recurrent miscarriage (RM) are contr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.6
- DOI:
- 10.4238/2013.September.23.6