Medical Genetics
Effects of Sirtuin 1 on the proliferation and osteoblastic differentiation of periodontal ligament stem cells and stem cells from apical papilla
Authors: Q.-B. Zhang, W. Cao, Y.-R. Liu, S.-M. Cui and Y.-Y. Yan
The function of SIRT1 in the proliferation and osteoblastic differentiation of dental stem cells is unclear. The aim of this study was to assess the roles of SIRT1 in these processes using periodontal ligament stem cells (PDLSCs) and stem cells from apical papilla (SCAPs). A defined concentration of resveratrol, an SIRT1 activ.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15015234
- DOI:
- 10.4238/gmr.15015234
Molecular cloning and gene expression analysis of cystatin C-like proteins in spinyhead croaker Collichthys lucidus
Authors: W. Song, K.J. Jiang, F.Y. Zhang, M. Zhao and L.B. Ma
Cystatins are natural tight-binding reversible inhibitors of cysteine proteases. In this study, a cDNA library was constructed from Collichthys lucidus using the SMART technique. A complete cDNA sequence with high identity to the conserved sequence of the cystatin C gene was cloned from the library using EST analysis and rapid.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017417
- DOI:
- 10.4238/gmr.15017417
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population
Authors: B. Yang, J.R. Xu, X.M. Liu, Y. Yang, X.F. Na, M. Li and Y.J. Wang
We investigated a possible association of polymorphism of the eNOS gene and essential hypertension in the Chinese Hui population; polymorphisms of rs2070744 (T>C), rs1799983 (G>T), rs1800780 (A>G), and rs3918181 (A>G) loci of the eNOS gene were examined. We found that the genotypic frequencies at rs1799983 and rs1800780 loci differed significa.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.26.2
- DOI:
- 10.4238/2013.March.26.2
Glucocorticoid receptor expression in the tonsils of children with obstructive sleep apnea hypopnea syndrome
Authors: X. Chen and J.R. Li
The expression of glucocorticoid receptor-α and -β (GR-α and GR-β) in the tonsil tissues of children with and without obstructive sleep apnea hypopnea syndrome (OSAHS) was evaluated. A total of 30 children with OSAHS who underwent tonsillectomy in the Navy General Hospital from June 2012 to June 2014 were.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017361
- DOI:
- 10.4238/gmr.15017361
miRQuest: integration of tools on a Web server for microRNA research
Authors: R.R. Aguiar, L.A. Ambrosio, G. Sep�?ºlveda-Hermosilla, V. Maracaja-Coutinho and A.R. Paschoal
This report describes the miRQuest - a novel middleware available in a Web server that allows the end user to do the miRNA research in a user-friendly way. It is known that there are many prediction tools for microRNA (miRNA) identification that use different programming languages and methods to realize this task. It is diffic.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016861
- DOI:
- 10.4238/gmr.15016861
Development and characterization of Rift Valley fever virus-like particles
Authors: Y.T. Li, C.L. Wang, X.X. Zheng, H.L. Wang, Y.K. Zhao, W.W. Gai, H.L. Jin, Y.W. Gao, N. Li, S.T. Yang and X.Z. Xia
Rift Valley fever (RVF) is an acute, febrile zoonotic disease that is caused by the RVF virus (RVFV) and spread by arthropod vectors. RVF is currently prevalent in Africa and the Arabian Peninsula, and causes substantial economic losses. Furthermore, this disease poses a serious threat to animal and human health in regions wor.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017772
- DOI:
- 10.4238/gmr.15017772
Impact of cold ischemia on cytokines after partial liver transplantation in rats
Authors: Q.-A. Qi, Z.-Y. Yang, K.-S. Ma, Q. Lu, S.-G. Wang, X.-W. Li, F. Xia, W. Liu and P. Bie
To study the impact of cold ischemia on tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) expression after liver transplantation, a stable model of partial liver transplantation in rats was established. The experimental animals were divided into the following groups: a partial hepatectomy control group, a group that received partial liv.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.1
- DOI:
- 10.4238/2013.September.27.1
De novo assembly and characterization of farmed blue fox (Alopex lagopus) global transcriptome using Illumina paired-end sequencing
Authors: P.C. Guo1*, S.Q. Yan1*, S. Si1, C.Y. Bai1, Y. Zhao1, Y. Zhang1, J.Y. Yao2 and Y.M. Li1
The blue fox (Alopex lagopus), a coat-color variant of the Arctic fox, is a domesticated fur-bearing mammal. In the present study, transcriptome data generated from a pool of nine different tissues were obtained with Illumina HiSeq2500 paired-end sequencing technology. After filtering from raw reads, 32,358,290 clean reads wer.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017603
- DOI:
- 10.4238/gmr.15017603
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
Authors: X.J. Qi, J.F. Wang, G.D. Wang, Q. Xu and H.L. Sun
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017318
- DOI:
- 10.4238/gmr.15017318
A new method for estimating the number of non-differentially expressed genes
Authors: J. Wu, C.Y. Liu, W.T. Chen, W.Y. Ma and Y. Ding
Control of the false discovery rate is a statistical method that is widely used when identifying differentially expressed genes in high-throughput sequencing assays. It is often calculated using an adaptive linear step-up procedure in which the number of non-differentially expressed genes should be estimated accurately. In this paper, we discuss the estim.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017402
- DOI:
- 10.4238/gmr.15017402